Importance of surgical margin in the outcomes of hepatocholangiocarcinoma

Table 1 Demographic characteristics and baseline biochemistry of the study population

	No. of patients = 42
Male:female	29:13
Age (yr)	52.5 (26-72)
Hepatitis B virus carrier	31 (73.8%)
Hepatitis C virus carrier	0
Hemoglobin (g/dL)	13.4 (8.6-16.7)
White cell count (10 × 6/L)	5.8 (3.5-10.1)
Platelet count (10 × 9/L)	185 (89-499)
Creatinine (mmol/L)	84 (61-131)
Total bilirubin (mmol/L)	10 (2-61)
Albumin (g/L)	40 (29-49)
Aspartate transaminase (umol/L)	44 (14-270)
Alkaline phosphatase (umol/L)	92 (26-516)
Prothrombin time (s)	13.5 (10.9-13.5)
Alpha-fetoprotein (u/L)	75.5 (2-219020)
Carcinoembryonic antigen (u/L)	2.3 (0.4-5.9)

Data are presented as median (range) unless otherwise stated.

Table 2 Types of operative procedure performed

	No. of patients (%)
Right/extended right hepatectomy	17 (40.5)
Left/extended left hepatectomy	5 (11.9)
Right trisectionectomy	6 (14.3)
Left trisectionectomy	1 (2.4)
Central bisectionectomy	2 (4.8)
Left lateral sectionectomy	3 (7.1)
Other minor hepatectomy	8 (19.0)

Table 3 Cox regression analysis for factors affecting overall and disease-free survival

Factor	Overall survival (P-value)		Disease-free survival (P-value)
	Univariate	Multivariate	Univariate	Multivariate
Age	0.269	NS	0.501	NS
Sex	0.513	NS	0.868	NS
HBV status	0.507	NS	0.441	NS
Platelet count	0.389	NS	0.331	NS
Total bilirubin	0.471	NS	0.176	NS
Albumin	0.811	NS	0.663	NS
ICG-R15	0.955	NS	0.749	NS
AFP	0.937	NS	0.308	NS
CEA	0.832	NS	0.716	NS
Operation time	0.239	NS	0.682	NS
Blood loss	0.138	NS	0.037	NS
Resection extent1	0.152	NS	0.108	NS
Tumor size	0.845	NS	0.975	NS
Multifocality	< 0.0001	< 0.001	< 0.0001	0.001
Margin width	0.523	NS	0.9	NS
Wide margin (≥ 1 cm)	0.491	NS	0.096	NS
Microvascular invasion	0.373	NS	0.170	NS
Nodal metastasis	0.314	NS	0.229	NS
Adjuvant treatment	0.162	NS	0.052	NS

¹Major vs minor. NS: Not significant; HBV: Hepatitis B virus; ICG-R15: Indocyanine green retention rate at 15 min after injection; AFP: Alpha-fetoprotein; CEA: Carcinoembryonic antigen.