Retrospective Study
Copyright ©The Author(s) 2017.
World J Hepatol. Apr 8, 2017; 9(10): 510-518
Published online Apr 8, 2017. doi: 10.4254/wjh.v9.i10.510
Table 1 Population characteristics
Total cohort (n)Overt HE1 (n)No HE1 (n)
Demographics1658877
Gender
Male1196851
Female462026
Mean age (years ± SD)53 ± 852 ± 754 ± 8
Primary indication for liver transplantation
Viral hepatitis915239
Alcoholic cirrhosis23185
Cholestatic disease (PBC, PSC, autoimmune)301020
Non-alcoholic steatohepatitis761
Other14212
Ethnicity
Caucasian1307555
Asian22616
Middle Eastern844
Other532
Clinical characteristics
CTP score mean ± SD9 ± 2.511 ± 1.7a7 ± 2a
CTP stage
A410a41a
B472225
C7766a11a
Ascites
None517a44a
Medically controlled5436a18a
Poorly controlled6045a15a
BMI (kg/m2 ± SD)27.4 ± 5.228.7 ± 5.4a25.7 ± 4.2a
Nutritional status1046539
SGA: A (well nourished)1293
SGA: B (moderately malnourished)654025
SGA: C (severely malnourished)271611
Biochemical characteristics
25-OHD (vitamin D) (nmol/L) mean ± SD36 ± 1530 ± 13a42 ± 16a
MELD score mean ± SD17.1 ± 6.819.9 ± 6. 5a13.9 ± 5.7a
Bilirubin (μmol/L) mean ± SD114 ± 152141 ± 167a83 ± 128a
Creatinine (μmol/L) mean ± SD84 ± 5085 ± 35a83 ± 63
Albumin (g/L) mean ± SD33 ± 631 ± 5a35 ± 6a
INR mean ± SD1.6 ± 0.51.8 ± 0.6a1.3 ± 0.3a
Sodium (mmol/L) mean ± SD136 ± 5135 ± 5a138 ± 4a
Zinc (μmol/L) mean ± SD8 ± 48 ± 3a10 ± 5a
Table 2 25-hydroxyvitamin D categories in patients assessed for liver transplantation
25-OHD (nmol/L)Total numberOvert HE1 (n = 88)No overt HE1 (n = 77)
Sufficient> 75202
Insufficient50-7527621
Mildly deficient25-50874641
Moderately deficient12.5-254230a12a
Severely deficient< 12.5761
Table 3 Univariate 25-hydroxyvitamin D correlations with physical and biochemical markers determined by Spearman correlation
Spearman rP valueSignificance
Age0.11100.16ns
Total bilirubin-0.3493< 0.0001f
Albumin0.3153< 0.0001f
ALP0.02030.80ns
GGT0.20550.0081b
ALT0.02460.75ns
AST-0.17410.0253a
Creatinine-0.06870.38ns
Na+0.26660.0005e
Zn+0.27900.0004e
RBP0.29130.0002e
Transferrin0.3568< 0.0001f
INR-0.4232< 0.0001f
Ca2+0.23700.0022b
Ca2+ corrected-0.15310.08ns
PTH-0.18240.0205a
BMI-0.22440.0055b