New advances in hepatocellular carcinoma

Table 1 Factors included in each staging system

Staging system	Size	Nodules	Met	PVT	AFP	CH	Alb	Bil	ALP	Ascites	PS
TNM	Yes	Yes	Yes	No	No	No	No	No	No	No	No
Okuda	Yes	No	No	No	No	No	Yes	Yes	No	Yes	No
CLIP	Yes	No	No	Yes	Yes	Yes	No	No	No	No	No
FRENCH	No	No	No	Yes	Yes	No	No	Yes	Yes	No	Yes
BCLC	Yes	Yes	Yes	Yes	No	Yes	No	Yes	No	No	Yes
JIS	Yes	Yes	Yes	No	No	Yes	No	No	No	No	No
CUPI	Yes	Yes	Yes	No	Yes	No	No	Yes	Yes	Yes	No

Met: Metastasis; PVT: Portal vein thrombosis; AFP: Alfafetoproteina; Alb: Albumin; Bil: Bilirubin; ALP: Alkaline phosphatise; PS: Performance status; CLIP: Cancer of the Liver Italian Program; BCLC: Barcelona clinic liver cancer classification; CUPI: Chinese University Prognosis Index; JIS: The Japan Integrated Staging; TNM: Classification of malignant tumours; FRENCH: French classification of hepatocellular carcinomas; CH: Child-Pugh.

Table 2 Reported 5-year overall survival and recurrence in patients undergoing liver transplant for hepatocellular carcinoma within Milan criteria

Ref.	n	5-yr overall survival	5-yr recurrence
Mazzaferro et al[155]	48	74%	8%
Bismuth et al[149]	45	74%	11%
Llovet et al[147]	79	75%	4%
Jonas et al[151]	120	71%	15%
Yao et al[158]	64	72%	6.5%
Marsh et al[153]	248	67%	3.6%
Herrero et al[154]	47	70%	8.5%
Mazzaferro et al[155]	444	73%	4.3%

Table 3 Summary of the characteristics of the published studies including patients within Milan criteria or with expanded criteria

Ref.	Patients MC/EC	HCC criteria	Staging method	Design	5-yr survival (%) MC/EC
Yao et al[158] UCSF criteria	46/14	1 < 6 cm	Explant	Retro	72
		2-3 > 4, 5 cm
		Sum diameter < 8 cm
Herrero et al[154] Navarra Criteria	35/12	1 < 6 cm	Rx	Pros
		2-3 < 5 cm
Kneteman et al[157]	19/21	1 < 7.5 cm	Explant	Pros	87/83 (4-yr)
	18/9	Multinodular < 5 cm	Rx		92/77
Yao et al[152]	130/38	1 < 6 cm	Rx	Pros	90/93
		2-3 > 4, 5 cm
		Sum diameter < 8 cm
Silva et al[159] Valencia Criteria	231/26	1 < 5 cm	Explant	Retro	62/69
	254/27	2-3 < 5 cm	Rx
		Sum diameter 10 cm
Herrero et al[156]	59/26	1 < 6 cm	Explant	Pros	70/56
		2-3 < 5 cm	Rx		66/68
Mazzaferro et al[155] Metroticket	444/283	Sum nodules/size	Explant	Retro	73/71
		7 cm
Fan et al[160] Shanghai Criteria	394/176	1 < 9 cm	Explant	Retro	51/65
		2-3 < 5 cm
		Sum diameter 9 cm
Guiteau et al[161]	363/82	1 < 6 cm	Rx	Pros	73/71 (3-yr)
		2-3 < 5 cm
		Sum diameter 9 cm

Staging method: Pre LT with radiological features (Rx) or post LT according to histopathological features (Explant). Study design: retrospective (Retros), prospective (Pros). MC: Milan criteria; EC: Expanded criteria; LT: Liver transplant; UCSF: University of California, San Francisco; HCC: Hepatocellular carcinoma.