Significant cohort of non-alcoholic fatty liver disease with portal vein thrombosis in transplant waiting list

Table 1 Classification of study groups

	NAFLD	Hepatitis B	Hepatitis C	Others	Total	P value
n (%)	101 (39.0)	75 (29.1)	29 (11.2)	53 (20.5)	258 (100)
Mean age (median; range of years)	56.4 ± 16.0 (59; 24-83)	57.8 ± 13.3 (58; 24-90)	62.9 ± 12.2 (65; 28-79)	48.1 ± 13.9 (48; 25-81)b	55.8 ± 15.0 (58; 24-90)	< 0.0001
% men	62.4%	80.0%a	58.6%	58.5%	66.3%	< 0.05

Study groups were classified per etiology: NAFLD, hepatitis B, hepatitis C and others. Mean age in patients with NAFLD, hepatitis B and C that was higher than the mean age of patients with other etiologies (^bP < 0.0001 others vs each of NAFLD, hepatitis B and C vs other etiologies). Percentage of men with hepatitis B was higher than those with NAFLD, hepatitis C and other etiologies (^aP < 0.05 patients with hepatitis B vs NAFLD, hepatitis C and other etiologies). NAFLD: Non-alcoholic fatty liver disease.

Table 2 Incidence of pathologies and mortality

	Cirrhosis	PVT	HCC	Fundic varices	Mortality
NAFLD	100%	47.5%	5.0%d	45.5%	47.5%
Hepatitis B	86.7%	29.3%	26.7%	52.0%	42.7%
Hepatitis C	93.1%	17.2%b	34.5%	27.6%	51.7%
Others	69.8%f	62.3%	5.7%d	43.4%	30.2%
Total	89.1%	41.9%	14.7%	45.0%	43.0%
P value	< 0.0001	< 0.0001	< 0.0001	> 0.05	> 0.05

The distribution of portal vein thrombosis (PVT), cirrhosis, hepatocellular cancer (HCC), fundic varices, and mortality rate in patients with NAFLD, hepatitis B, hepatitis C and other liver-related diseases (others) is shown.

^bP < 0.0001;

^dP < 0.0001; and

^fP < 0.0001. Different symbols were used in order to emphasize comparison within each etiology group. NAFLD: Non-alcoholic fatty liver disease.

Table 3 Incidence of portal vein thrombosis

	Cirrhosis (P > 0.05)	HCC (P > 0.05)	Fundic varices (P < 0.0001)	Mortality rate (P = 0.057)
PVT (+)	86% (93 patients)	13% (14 patients)	61%b (66 patients)	36.1% (39 patients)
PVT (–)	91% (137 patients)	16% (24 patients)	33% (50 patients)	48.0% (72 patients)

The incidence of portal vein thrombosis (PVT) in patients with cirrhosis, hepatocellular cancer (HCC) and fundic varices are shown. Also reported is the relationship between PVT and the mortality rate. Each of these pathologies and mortality rate was compared in patients with and without PVT.

^bP < 0.0001 in the presence vs absence of PVT.

Table 4 Relationship among fundic varices, cirrhosis, hepatocellular cancer, and mortality rate

Fundic varices	Cirrhosis	HCC	Mortality rate
Yes	Yes	Yes	70.6%
		No	28.6%
	No	Yes	100%
		No	28.6%
No	Yes	Yes	85%
		No	23.1%
	No	Yes	No patients in this group
		No	23.1%

HCC: Hepatocellular cancer.