Impaired liver function attenuates liver regeneration and hypertrophy after portal vein embolization

Table 1 Patient characteristics and liver regeneration rate after hepatectomy in 26 patients who underwent right hepatectomy or extended right hepatectomy vs 32 patients who underwent left hepatectomy or extended left hepatectomy

	Right hepatectomy				Left hepatectomy
		n	Regeneration rate (%)1	P		n	Regeneration rate (%)1	P
Age (mean)	45-83 (69)			P = 0.891	46-89 (69)			P = 0.321
Sex (male/female)		18/8	65.6/69.2	P = 0.355		20/12	25.7/25.9	P = 0.969
Background liver disease (yes/no)		6/20	51.0/70.2	P = 0.248		14/18	24.0/25.7	P = 0.621
Platelet count (/mm3) ≥ 100		24	69.3	P = 0.178		30	24.7	P = 0.586
< 100		2	41.6			2	28.8
Total bilirubin (mg/dL ) ≥ 1.5		1	71.8	P = 0.842		4	28.2	P = 0.724
< 1.5		25	64.4			27	24.9
ICG-R15 (%) ≥ 20		4	28.5	P < 0.05		4	28.2	P = 0.724
< 20		22	72.7			27	24.9
Diabetes mellitus (yes/no)		4/22	63.7/65.6	P = 0.570		4/28	37.8/24.7	P = 0.459
Preoperative chemotherapy (yes/no)		10/16	60.0/74.5	P = 0.317		8/24	29.7/24.1	P = 0.361

¹Median. ICG-R15: Indocyanine green retention rate at 15 min.

Table 2 Patient characteristics and hypertrophic rate in 13 patients who underwent portal vein embolization

		n	Hypertrophic rate (%)1	P
Age (mean)	50–80 (65)			P = 0.845
Sex (male/female)		10/3	30.5/40.1	P = 0.612
Background liver disease (yes/no)		6/7	23.1/40.1	P = 0.087
Platelet count (/mm3) ≥ 100		12	30.5	P = 0.593
< 100		1	40.1
Total bilirubin (mg/dL) ≥ 1.5		4	19.7	P < 0.05
< 1.5		9	40.0
ICG-R15 (%) ≥ 20		2	12.0	P < 0.05
< 20		11	34.2
Diabetes mellitus (yes/no)		3/10	32.2/31.4	P = 1.000
Preoperative chemotherapy (yes/no)		3/10	40.1/26.8	P = 0.237

¹Median. ICG-R15: Indocyanine green retention rate at 15 min.