Predictive potential of IL-28B genetic testing for interferon based hepatitis C virus therapy in Pakistan: Current scenario and future perspective

Table 1 Summary of interleukin 28B and interferon based therapy response in hepatitis C virus patients in Pakistan

Year	Viral genotype	Patients (n)	Objective/SNP investigated	Findings/conclusion	Ref.
2015	3a	66	IL-28B protein levels	IL-28B protein levels were significantly associated with therapy response	[5]
2015	3	105	rs8099917	TT genotype favors RVR	[6]
			rs12979860	CC genotype favors SVR
2015	1a,1b, 3a	111	rs12979860	CC genotype favors SVR in HCV 3a genotype	[7]
2015	1a, 1b, 3a, 3b, 4, UT	140	rs8099917	No association was observed with therapy response	[8]
			rs12979860	CC genotype favors SVR
2014	(2a, 3a, UT)	220	rs8099917	No association was observed with therapy response	[9]
			rs12979860	No association was observed with therapy response
			rs12980275	AA genotype favors SVR
2014	3a	200	rs12979860	TT genotype favors SVR	[10]

Genotyping performed only for non-responders patients. SVR: Sustained virological response; RVR: Rapid virological response; UT: Untypable; IL-28B: Interleukin 28B; HCV: Hepatitis C virus; SNP: Single nucleotide polymorphism.