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Copyright ©The Author(s) 2016.
World J Hepatol. Jun 18, 2016; 8(17): 716-725
Published online Jun 18, 2016. doi: 10.4254/wjh.v8.i17.716
Table 1 Innate immune cells, molecules and signaling pathways targeted by hepatitis B virus and hepatitis B virus proteins
HBV and HBV proteinsInnate immune cells, molecules and signaling pathwaysRef.
HBsTLR, ISG, IRF3, IFN-β and NF-κB[20]
KCs, LSECs, IFN-γ, ISGs, MAPKs, TLR3[21]
JNK/MAPK, κBα[24,25,87]
mDCs, pDCs, TLR-9[42,43]
HBeHepatocytes, KCs, PBMCs, and TLR2, ISG, IRF3, IFN-β and NF-κB[20,22]
TRAM, Mal, TLR2, and TIR:TIR[28]
NF-κB and IFN-β promoter, IFN-γ[29,62]
HBxTRIF, RIG-I/MDA5, VISA, MAVS, NF-κB[31-33,82]
NEMO, TBK1, IKKi, and IRF3[75]
HBV PolRIG-I, DDX3, NEMO-Cdc37/Hsp90β[35,36,81]
TBK1/IKKi, STAT1, PP2A, STING[32,33,36,76,77,80]
HBVNK, NKG2D, NKG2A, CD16, NKp30, and NKp46[56,58,59]
pDC–NK, NKT[63,72]