Copyright ©The Author(s) 2015.
World J Hepatol. Apr 8, 2015; 7(4): 688-695
Published online Apr 8, 2015. doi: 10.4254/wjh.v7.i4.688
Table 1 Natural history of cirrhosis
Stages of cirrhosis
Mortality risk at 1 yr
≤ 1%1%-20%> 20%
Clinical featuresAsymptomatic no varicesVarices/ascites or bothBleeding/re-bleeding SBP Refractory ascites HRS/AKI Infection other than SBP
HVPG of risk10 mmHg12/16/20 mmHg
Main outcome to preventDecompensation and/or HCC and/or varicesDecompensation and/or HCC mortalityHCC and/or mortality
Main pathophysiologic factorIntrahepatic structural and hemodynamic changes Portal pressureExtrahepatic hemodynamic changes Portal pressureHepatocellualr dysfunction Portal pressure Cytokine release Peripheral perfusion Coagulopathy? Other?