PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis

doi:10.4254/wjh.v7.i29.2920

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Dec 18, 2015; 7(29): 2920-2926
Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2920

Table 1 Main demographic and clinical characteristics of patients with hepatitis C/B virus liver cirrhosis, defined virus liver cirrhosis and alcoholic and cryptogenic, aggregated as non-virus cirrhosis

	Total (%)	VLC (%)	Alcoholic (%)	Crypto (%)	NVLC (%)
Patients	1079 (100)	729 (100)	102 (100)	248 (100)	350 (100)
Age (range)	57 (19-83)	60 (24-83)	55 (19-80)	49 (19-83)	51 (19-83)
Male sex	620 (57.5)	384 (52.7)	81 (79.4)	155 (62.5)	236 (67.4)
PVT/BCS	352 (32.6)	230 (31.5)	45 (44.1)	77 (31.0)	122 (34.8)
MVT/SVT	53 (4.9)	33 (4.5)	6 (5.8)	14 (5.6)	20 (5.7)
L-M varices	445 (41.2)	574 (78.7)	48 (47.0)	150 (60.4)	245 (70.0)
N° bleeding	360 (33.3)	265 (36.3)	41 (40.1)	54 (21.7)	95 (27.1)
Child A/B/C	416/242/430 (38.5/22.4/39.8)	241/194/294 (33.0/26.6/40.3)	31/53/17 (30.3/51.9/16.6)	129/31/83 (52.0/12.5/33.4)	165/48/17 (47.1/13.7/39.1)

No statistical differences between VLC vs NVLC group: All χ² > 3.85 and P < 0.05. VLC: Virus liver cirrhosis; NVLC: Non-virus cirrhosis; PVT: Portal vein thrombosis; BCS: Budd Chiari syndrome; MVT: Mesenteric vein thrombosis; SVT: Splenic vein thrombosis.

Table 2 Frequencies of thrombophilic genetic factors, PAI-1 4G-4G, MTHFR 677TT, V Leiden 506Q and prothrombin 20210A, in patients with hepatitis C/B virus liver cirrhosis, alcoholic and cryptogenic, aggregated as non-virus cirrhosis

	(A) VLC (%)	Alcoholic (%)	Crypto (%)	(B) NVLC (%)	(A) vs (B)χ²: P value; OR (95%CI)
Patients	729 (100)	102 (100)	248 (100)	350 (100)	-
PAI-1 4G-4G	95 (13.0)	33 (32.3)	89 (35.8)	122 (34.8)	68.2: 0.000; 3.6 (2.6-4.9)
MTHFR 677TT	99 (13.5)	14 (13.7)	63 (25.4)	77 (22.0)	11.7: 0.001; 1.8 (1.3-2.5)
V Leiden 506Q	41 (5.6)	9 (8.8)	22 (8.8)	30 (8.6)	3.3: 0.09; 1.5 (0.9-2.6)
Prothrombin 20210A	25 (3.4)	3 (2.9)	13 (5.2)	16 (4.5)	0.8: 0.39; 1.4 (0.7-2.7)
At least 1 THRGF	218 (29.9)	43 (42.1)	156 (62.9)	199 (56.9)	72.5: 0.000; 3.1 (2.4-4.1)
> 1 THRGF	40 (5.4)	14 (13.7)	30 (12.0)	44 (12.5)	16.5: 0.000; 2.5 (1.6-4.0)

VLC: Virus liver cirrhosis; NVLC: Non-virus cirrhosis; THRGF: Thrombophilic genetic factors.

Citation: Pasta L, Pasta F. PAI-1 4G-4G and MTHFR 677TT in non-hepatitis C virus/hepatitis B virus-related liver cirrhosis. World J Hepatol 2015; 7(29): 2920-2926
URL: https://www.wjgnet.com/1948-5182/full/v7/i29/2920.htm
DOI: https://dx.doi.org/10.4254/wjh.v7.i29.2920