Copyright ©The Author(s) 2015.
World J Hepatol. Dec 18, 2015; 7(29): 2896-2905
Published online Dec 18, 2015. doi: 10.4254/wjh.v7.i29.2896
Table 1 Mayo clinic criteria for recurrent primary sclerosing cholangitis after liver transplantation[12]
Inclusion criteria
Confirmed diagnosis of PSC before LT
Cholangiography showing non-anastomotic intra- and/or extra- hepatic biliary strictures with beading and irregularities of bile ducts at least 90 d after LT and/or
Histopathological findings of fibrous cholangitis and/or fibro- obliterative lesions
Exclusion criteria
Hepatic artery thrombosis or stenosis
Chronic ductopenic rejection
Anastomotic and non-anastomotic strictures before day 90 after LT
ABO incompatible LT
Table 2 Diagnostic criteria for recurrent primary biliary cirrhosis after liver transplantation[49]
Confirmed diagnosis of PBC in the explant histology
Characteristic histologic features1
Lymphoplasmacytic portal infiltrate
Lymphoid aggregates
Epithelioid granulomas
Evidence of bile duct injury
Persistence of AMA or AMA-M2
Exclusion of other causes of graft dysfunction
Acute and chronic rejection
Graft vs host disease
Bile flow impairment or cholangitis
Vascular complications
Viral hepatitis
Drug induced hepatitis
Table 3 Diagnostic criteria of recurrent autoimmune hepatitis[60,64,69]
Liver transplantation for confirmed diagnosis of autoimmune hepatitis
Elevated transaminases
Hyper-gammaglobulinemia (elevation of IgG)
Presence of autoantibodies (ANA, SMA and/or anti-LKM1)
Compatible histopathology (interface hepatitis with portal inflammation and/or lymphoplasmacytic inflammatory infiltrates)
Response to corticosteroid
Exclusion of differential diagnostic considerations (including late/atypcial, acute cellular rejection)