Post-transplantation hepatocellular carcinoma recurrence: Patterns and relation between vascularity and differentiation degree

Table 1 Demographic and clinical characteristics of the study population

Demographic and clinical characteristics (n = 165)
Sex	Male (%)			143 (86.7)
	Female (%)			22 (13.3)
Median age (range)				56.8 (28; 70.4)
HIV + (%)				15 (9.1)
Etiology of the underlying hepatic disease	Viral (%)	136 (82.4)	HBV-related	28 (17.0)
			HCV-related	92 (55.8)
			Mixed	16 (9.7)
	Not viral (%)	29 (17.6)	Alcoholic	16 (9.7)
			Cryptogenetic	6 (3.6)
			Other	7 (4.2)

Table 2 Pre-Transplantation imaging enhancement pattern and histopathological differentiation degree

Pre-LT imaging and transplant pathology
Pre-LT imaging
Enhancement pattern (n = 163)	Hypervascular (%)	156 (95.7)
	Hypovascular (%)	7 (4.3)
Histopathology
Differentiation degree (n = 125)	Grade 1 (%)	19 (15.2)
	Grade 2 (%)	56 (44.8)
	Grade 3 (%)	40 (32)
	Grade 4 (%)	4 (3.2)
	Not assessable (%)	6 (4.8)

Table 3 Distribution of dynamic imaging enhancement patterns according to histopathological differentiation degrees

Dynamic imaging enhancement pattern and histopathological differentiation degree (n = 113)
Enhancement pattern	Grade 1	Grade 2	Grade 3	Grade 4	P value
Hypovascular	3	1	1	1	0.035
Hypervascular	15	52	37	3

Table 4 Recurrence patterns based on the location at the moment of the first recurrence and most common imaging features of recurrence

Recurrence patterns (n = 24)
Intrahepatic		7 (29.2%)
	Solitary nodule	3 (12.5%)
	Multifocal lesions	4 (16.7%)
Extrahepatic		14 (58.3%)
	Lung	9 (37.5%)
	Solitary nodule	4 (16.7%)
	Multiple nodules	5 (20.8%)
	Consolidation	/
	Bone	5 (20.8%)
	Osteolytic	5 (20.8%)
	Osteoblastic	/
	Lymph nodes	2 (8.3%)
	Brain	1 (4.2%)
	Spleen	1 (4.2%)
	Adrenal	1 (4.2%)
Intrahepatic and extrahepatic		3 (12.5%)