Copyright ©The Author(s) 2015.
World J Hepatol. Aug 18, 2015; 7(17): 2110-2118
Published online Aug 18, 2015. doi: 10.4254/wjh.v7.i17.2110
Table 1 Mouse models of obesity- and nonalcoholic steatohepatitis - associated hepatocellular carcinoma
ObesityInsulin resistanceSteatosisSteatohepatitisFibrosisHCC
Dietary models
Long-term HFDYesYesYesYesYesYes
High fat and fructose dietYesYesYesYesYesYes
Dietary in combination with chemotoxic agent models
DEN with HFDYesYesYesNoNoYes
STZ with HFDNoYesYesYesYesYes
DMBA with HFDYesN/AYesNoNoYes
Genetically engineered models
Liver-specific PTEN knockout mice and p110α transgenic miceNoNoYesYesYesYes
Liver-specific NEMO knockout miceNoNoYesYesYesYes
miR-122 knockout miceNoYesYesYesYesYes
FXR knockout miceNoYesYes (mild)Yes (mild)YesYes
AOX knockout miceNoN/AYesYesNoYes
MAT1A knockout miceNoNoYesYesYesYes
FLS mice crossed with ob/ob miceYesYesYesYesYesYes
Dominant negative form of RARα transgenic miceNoNoYesYesNoYes
Genetic manipulation in combination with dietary models
MUP-uPA transgenic mice with HFDYesYesYesYesYesYes
Adiponectin knockout mice with HFDYesYesYesYesYesNo (adenoma)
AIM knockout mice with HFDYesYesYesNoNoYes
MC4R knockout mice with HFDYesYesYesYesYesYes