Prediction of liver cirrhosis, using diagnostic imaging tools

Table 1 Diagnostic performance of ultrasonography elastography for hepatic fibrosis

Ref.	Year	Study method	Imaging instrument	Etiologies	No. of patients	Sensitivity (%)	Specificity (%)	Cut-offs	AUROC	Fibrosis score
Tada et al[33]	2015	Prospective	SSI	HCV	55	88.9	91.9	8.8 kPa	0.94	F2-3 (F4, excluded)
Samir et al[34]	2015	Prospective	SSI	Chronic viral and nonviralhepatopathies	136	91.4	52.5	7.29 kPa	0.84	≥ F2
Deffieux et al[63]	2015	Prospective	SSI	Chronic viral and nonviralhepatopathies	120	77	79	8.9 kPa	0.81	≥ F2
Yoon et al[35]	2014	Prospective	SSI	Chronic viral and nonviralhepatopathies	94	78.8	75.6	6.65 kPa	0.852	≥ F2
Tutar et al[36]	2014	Prospective	SSI	Children, viral and nonviralhepatopathies	76	97.8	96	10.4 kPa	0.96	≥ F2
Jeong et al[64]	2014	Prospective	SSI	Chronic viral and nonviralhepatopathies	70	78.2	93.3	8.6 kPa	0.915	≥ F2
Cassinotto et al[37]	2014	Prospective	SSI	Chronic viral and nonviralhepatopathies	336	83	82	8 kPa	0.89	≥ F2
			ARFI	Chronic viral and nonviralhepatopathies	341	72	81	1.38 m/s	0.81	≥ F2
			TE	Chronic viral and nonviralhepatopathies	337	76	81	8.5 kPa	0.83	≥ F2
Yap et al[31]	2013	Prospective	ARFI	Chronic viral and nonviralhepatopathies	70	68	66	1.55 m/s	0.85	≥ F2
Bota et al[32]	2013	Meta-analysis	ARFI	Chronic viral and nonviralhepatopathies	1163	74	83	1.30 m/s	0.85	≥ F2
			TE	Chronic viral and nonviralhepatopathies	1163	78	84	N/A	0.87	≥ F2
Ferraioli et al[65]	2012	Prospective	SSI	HCV	121	90	87.5	7.1 kPa	0.92	≥ F2
Chon et al[29]	2012	Meta-analysis	TE	HBV	2772	74.3	78.3	7.9 kPa	0.859	≥ F2
Friedrich-Rust et al[26]	2008	Meta-analysis	TE	Chronic viral and nonviralhepatopathies	8433	N/A	N/A	7.65 kPa	0.84	≥ F2

AUROC: Area under receiver operating characteristic; SSI: Supersonic shear wave imaging; HCV: Hepatitis C virus; ARFI: Acoustic radiation force impulse imaging; TE: Transient elastography (FibroScan™); HBV: Hepatitis B virus; N/A: Not applicable.

Table 2 Diagnostic performance of magnetic resonance elastography for hepatic fibrosis

Ref.	Year	Study method	Imaging instrument	Etiologies	No. of patients	Sensitivity (%)	Specificity (%)	Cut-offs	AUROC	Fibrosis score
Singh et al[66]	2015	Meta-analysis	1.5 Tesla, variable	Chronic viral and nonviralhepatopathies	697	79	81	3.66 kPa	0.88	≥ F2
Venkatesh et al[67]	2015	Retrospective	1.5 Tesla, (GE, Signa)	Chronic viral and nonviralhepatopathies	62	100	96.5	3.37 kPa	0.99	≥ F2
Yoon et al[56]	2014	Prospective	1.5 Tesla (GE, SignaHDx)	Chronic viral and nonviralhepatopathies	94	78.8	75.6	6.65 kPa	0.852	≥ F2
Venkatesh et al[68]	2014	Prospective	1.5 Tesla (GE, Signa)	HBV	63	97.4	100	3.2 kPa	0.99	≥ F2
Shi et al[69]	2014	Prospective	3.0 Tesla (GE, Signa Excite HD)	HBV	113	95	94.5	4.07 kPa	0.986	≥ F2
Loomba et al[70]	2014	Prospective	3.0 Tesla (GE, Signa Excite HD)	Nonalcoholic fatty liver disease	117	86	91	3.63 kPa	0.924	≥ F3
Bohte et al[71]	2014	Prospective	3.0 Tesla (Philips, Intera)	HBV, HCV	103	62	96	2.18 kPa	0.928	≥ F2
Kim et al[72]	2013	Retrospective	1.5 Tesla (GE, Signa)	Nonalcoholic fatty liver disease	142	85	92.9	4.15 kPa	0.954	≥ F3
Wang et al[73]	2012	Meta-analysis	1.5 Tesla, variable	Chronic viral and nonviralhepatopathies	972	94	95	N/A	0.98	≥ F2
Rustogi et al[54]	2012	Retrospective	1.5 Tesla (Siemens, Magnetom)	Chronic viral and nonviralhepatopathies	72	85.4	88.4	5.9 kPa	N/A	≥ F3
Kim et al[74]	2011	Prospective	1.5 Tesla GE, SignaHDx)	Chronic viral and nonviralhepatopathies	55	89.7	87.1	3.05 kPa	N/A	≥ F2

AUROC: Area under receiver operating characteristic; HBV: Hepatitis B virus; HCV: Hepatitis C virus; N/A: Not applicable.