Cross talk of the immune system in the adipose tissue and the liver in non-alcoholic steatohepatitis: Pathology and beyond

doi:10.4254/wjh.v7.i15.1905

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 7, Issue 15

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7269)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Tables (1-1) series.

Item

Count

PDF

432

WORD

233

HTML

3456

Tables (1-1)

223

Sum=4344

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1157

Download

1768

Sum=2925

Jul 28, 2015 (publication date) through Nov 22, 2024

Times Cited of This Article

Times Cited (19)

Journal Information of This Article

Publication Name

World Journal of Hepatology

ISSN

1948-5182

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Editorial

World J Hepatol. Jul 28, 2015; 7(15): 1905-1912
Published online Jul 28, 2015. doi: 10.4254/wjh.v7.i15.1905

Table 1 Treatment perspectives: Novel agents acting on the immune system

Treatment	Target	Effect
Anti-CD3 moAb	CD3	Reduction of liver enzymes and glucose and insulin levels
Imm124-E	Treg stimulation	Improvement of glucose metabolism parameters, lipid profile and liver injury
Adoptive transfer
Tregs		Reduction of TNFα-related inflammation
CD4⁺ T cells		Reverses weight gain and insulin resistance
NKT cells		Decreases body fat, triglyceride levels, leptin levels, hepatic steatosis and insulin sensitivity
RORγt ligands	RORγt	Th17 inhibition
Cenicriviroc	CCR2/5 inhibitor	Improvement of lipid metabolism and liver fibrosis
VAP-1	Lymphocytes recruitment	Anti-inflammatory en anti-fibrogenic effect

TNF: Tumour necrosis factor; ROR: RAR-related orphan receptor; CCR2: C-C chemokine receptor 2; VAP-1: Vascular adhesion protein-1; NKT: Natural killer T; Th17: T helper cell 17; Tregs: Regulatory T-cells; moAb: Monoclonal antibody.

Citation: Vonghia L, Francque S. Cross talk of the immune system in the adipose tissue and the liver in non-alcoholic steatohepatitis: Pathology and beyond. World J Hepatol 2015; 7(15): 1905-1912
URL: https://www.wjgnet.com/1948-5182/full/v7/i15/1905.htm
DOI: https://dx.doi.org/10.4254/wjh.v7.i15.1905