Surgical treatment of intra hepatic recurrence of hepatocellular carcinoma

Table 1 Major studies of outcomes of repeat hepatectomy for recurrent hepatocellular carcinoma from 2010

Ref.	Type of study	Patients (n)	Treatment	5 yr overall survival	Prognostic factors for time to recurrence
Zhou et al[26]	Systematic review	1149	Re resection	48.5%	Female gender
				(25%-87%)	Younger age
					Tumor grade
					Microvascular invasion
					Recurrent tumor > 3 cm
					Albumin < 35 g/L
Huang et al[23]	Retrospective study	82	Re resection	22.4%	Microvascular invasion
Chan et al[15]	Systematic review	1125	Repeat hepatectomy	52%	Blood transfusion
				(22%-83%)	Macro/microvascular invasion
					Tumor number
					Tumor size
					Liver status
Yamashita et al[17]	Retrospective study	163	Second hepatectomy	60%
		46	Third or more hepatectomy	43%
Tabrizian et al[27]	Retrospective study	356	Re resection: 19%	47%	Type of treatment
			Transplant listing: 16%	51%	Tumor number
			Local ablation: 17%	25%	Tumor size
			Embolization: 23%	9%	Alphafoeto protein rate
			Other: 12%	0%
			None: 7%	0%
Mise et al[16]	Retrospective study	289	Second hepatectomy	60.5%	Satellite nodules
		110	Third or more hepatectomy	68.5%

Table 2 Five years overall survival and prognostic factors for overall survival after salvage liver transplantation

Ref.	Type of study	Patients (n)	5 yr overall survival	Prognostic factors for overall survival
Sapisochin et al[24]	Case control study	17	52%
Wu et al[28]	Retrospective study	36	69.4%
Liu et al[29]	Retrospective study	39	61%
Fuks et al[11]	Retrospective study	138	71%
Guerrini et al[22]	Retrospective study	28	49.2%
Chan et al[20]	Systematic review	319	62%
Qu et al[30]	Retrospective Study	111	49.5%	Edmonson grade
				Hepatic vein invasion
				Portal vein invasion
				TNM stage
Lee et al[31]	Retrospective study	69	54.6%	Time to recurrence
				Alpha foetoprotein > 200 ng/mL
				HCC outside Milan criteria

HCC: Hepatocellular carcinoma.