MicroRNAs dysregulation in hepatocellular carcinoma: Insights in genomic medicine

Table 1 Upregulated miRNAs in hepatocellular carcinoma

MiRNA	Cellular process	Ref.
MiR-10a	Epithelial to mesenchymal transition and metastasis	[50]
MiR-130a	Drug resistance	[51]
MiR-135a	Metastasis	[52]
MiR-143	Metastasis	[53]
MiR-155	Proliferation and tumorigenesis	[54]
MiR-18a	Proliferation	[55]
MiR-181b	Cell growth, tumorigenesis and metastasis	[56]
MiR-182	Metastasis	[57]
MiR-183	Apoptosis	[47]
MiR-21	Metastasis and drug resistance	[39,58,59]
MiR-210	Metastasis, apoptosis and proliferation	[60,61]
MiR-216a	Tumorigenesis	[62]
MiR-221	Apoptosis, proliferation and angiogenesis	[42,45,63,64]
MiR-224	Metastasis, proliferation and apoptosis	[65-67]
MiR-23a	Gluconeogenesis	[68]
MiR-373	Cell cycle	[69]
MiR-301a	Metastasis	[70]
MiR-490-3p	Epithelial to mesenchymal transition	[71]
MiR-519d	Proliferation, invasion and apoptosis	[72]
MiR-550a	Metastasis	[73]
MiR-590-5p	Metastasis and proliferation	[74]
MiR-615-5p	Cell growth and migration	[75]
MiR-657	Proliferation	[76]
MiR-96	Proliferation	[77,78]
MiR-222	Metastasis	[79]

MiRNAs: MicroRNAs.

Table 2 Downregulated microRNAs in hepatocellular carcinoma

MiRNA	Cellular process	Ref.
Let-7a	Apoptosis and proliferation	[107,108]
Let-7b	Apoptosis and proliferation	[109]
Let-7c	Apoptosis, proliferation and cell growth	[110-112]
Let-7d	Apoptosis and proliferation	[107]
Let-7f-1	Apoptosis and proliferation	[107]
Let-7g	Apoptosis and metastasis	[113-115]
MiR-1	Proliferation	[116]
MiR-34a	Metastasis	[96]
MiR-101	Apoptosis and DNA methylation	[110,117,118]
MiR-122	Apoptosis, metastasis and angiogenesis	[119-122]
MiR-124	Proliferation	[123]
MiR-125a	Proliferation, metastasis and metabolism	[124-126]
MiR-125b	Proliferation, metastasis, angiogenesis, apoptosis and histone modification	[110,125-127]
MiR-139	Metastasis	[128,129]
MiR-138	Cell cycle	[130]
MiR-145	Cell growth and tumorigenesis	[131]
MiR-195	Tumorigenesis, cell cycle and apoptosis	[132,133]
MiR-199a-3p	Drug resistance and cell growth	[101,134]
MiR-199a-5p	Invasion and autophagy	[135]
MiR-200a	Proliferation and metastasis	[136]
MiR-203	Proliferation	[137]
MiR-214	Cell growth, metastasis and angiogenesis	[138,139]
MiR-219-5p	Proliferation	[140]
MiR-223	Proliferation	[141]
MiR-26a/b	Cell cycle	[142]
MiR-29a	Proliferation	[143]
MiR-34a	Metastasis	[96,144]
MiR-375	Autophagy	[145]
MiR-376a	Apoptosis and proliferation	[146]
MiR-449	Proliferation and apoptosis	[147]
MiR-450a	Proliferation	[148]
MiR-520b	Cell growth and proliferation	[149]
MiR-7	Tumorigenesis and metastasis	[150]

MiRNAs: MicroRNAs.