Research Report
Copyright ©2014 Baishideng Publishing Group Inc.
World J Hepatol. May 27, 2014; 6(5): 340-346
Published online May 27, 2014. doi: 10.4254/wjh.v6.i5.340
Table 1 Characteristics of the study population (n = 39)
Demographic characteristicsMean ± SD/median (IQR) or frequencies1Range2
Age (yr)42 (29-62)20-75
Gender (M/F)22(56%) 17(44%)-
Height (cm)172.62 (10.55)152-192
Weight (Kg)82.7 (20.55)35-140
BMI (Kg/m2)27.66 (6.14)12.85-41.91
ASA I/II/III16 (41%)/22 (56%)/1 (3%)-
Anesthetic data
Previous anesthesias (no/yes)12 (31%)/27 (69%)-
No of previous anesthesias1 (0-2)0-6
Duration of anesthesia (min)150 (90-180)30-360
Length of stay (d)5 (4-7)2-15
Type of operation (n)Orthopedic: 35
Fractures: 18
Arthroscopies: 12
Knee/hip arthroplasties: 5
Thyroidectomies (non-malignant): 3
Saphenectomy: 1
Table 2 Comparison of blood test measurements before (baseline) and 96 h after exposure to desflurane
Baseline measurementsMeasurements after interventionP value1
Blood count
HCT (%)41.2 (37.4-43)36.75 (31.65-41.7)0.016
HBG (g/dL)13.56 (1.944)12.01 (1.941)0.002
WBC7907.94 (2218.9)8330 (1826.7)0.446
PLT (x 103)251 (217-284)241 (205-276)0.259
Liver function tests
SGOT (IU/L)20 (17-25)21.5 (17-28)0.489
SGPT (IU/L)19 (14-39)19.5 (13-30)0.987
ALP (IU/L)64 (46-77)54 (47-63)0.222
γGT (IU/L)22.5 (13-35)23 (13-30)0.532
Direct bilirubin (mg/dL)0.2 (0.13-0.21)0.185 (0.1-0.2)0.277
Indirect bilirubin (mg/dL)0.5 (0.3-0.7)0.4 (0.3-0.6)0.840
Total bilirubin (mg/dL)0.6 (0.5-1)0.6 (0.4-0.7)0.610
Proteins (g/dL)6.3 (6-6.7)5.9 (5.35-6.45)0.082
Albumin (g/dL)4.1 (3.7-4.3)3.5 (3.15-3.95)0.013
PT (s)11.9 (11.23-13)12.55 (11.6-13.5)0.219
aPTT (s)27.97 (3.09)29.83 (5.09)0.125
INR0.97 (0.92-1.08)1.02 (0.9-1.1)0.346
IgG4 (g/L)0.04 (0.02 -0.5)0.065 (0.02-0.415)0.576
αGST (ng/mL)3.5 (1.69-4.38)3.03 (1.11-4.87)0.489
Table 3 Multivariate linear regression model of the mean difference of alpha-glutathione-S-transferase adjusted for gender, body mass index, duration of anesthesia, number of times anesthesia was administered previously, and length of stay
αGSTCoefficientStandard errorP value95%CI
Gender2.151.020.04910.0111-4.284
Length of stay-0.4450.2020.041-0.868-(-0.0229)
Duration0.03230.0080.00110.0157-0.0489
Table 4 Comparisons of IgG4 and alpha-glutathione-S-transferase levels according to medical history of receiving or not receiving anesthesia previously
No previous anesthesia (n = 12)Previous anesthesia (n = 27)P value1
IgG4 levels
Baseline0.025 (0-0.04)0.08 (0.02-0.66)0.099
96 h after anesthesia0.035 (0-0.07)0.105 (0.03-0.74)0.051
αGST levels
Baseline2.94 (1.69-3.94)3.54 (1.42-5.87)0.505
96 h after anesthesia3.825 (3.02-5.4)2.65 (1.05-4.33)0.147