Copyright ©2014 Baishideng Publishing Group Co.
World J Hepatol. Apr 27, 2014; 6(4): 188-198
Published online Apr 27, 2014. doi: 10.4254/wjh.v6.i4.188
Table 1 Rodent resveratrol studies with histological liver data
Ref.FocusModelRSV doseRSV exposure(wk)Histology/LWTG/CH contentLiverAMPK activationSuggested RSV actions/mechanisms
Baur et al[37] (2006)LongevityMiddle-aged DIO mice22.4 mg/kg BW = 0.04% in diet27+/+ND+Elevated PGC-1α deacetylation as marker of enzymatic SIRT1 activity. Phosphorylation of ACC
Ahn et al[65] (2008)NAFLD/NASHDIO mice (1% CH in diet)1.25 g/kg diet8+/+ Decrease in NASH+/-NDReduced hepatic expression of FAS, PPARγ, CD36. Increased PPARα expression
Kang et al[46] (2010)Insulin signalingDIO mice30 mg/kg BW2+/NDND-Increased Akt phosphorylation, improving insulin signaling
Labbé et al[109] (2011)NAFLD, metabolic profile, longevityWerner syndrome mice0.04% RSV in dietLife-long ( ≤ 22.5 mo)+/NDND-Decreased FAS expression Decreased HCC prevalence
Tauriainen et al[115] (2011)Obesity, NAFLDDIO mice2 or 4 g/kg diet15+/NDNDNDIncreased SIRT1 expression in liver tissue. High-dose most effective
Cho et al[111] (2012)NAFLDDIO mice (1% CH in diet)7 mg/kg BW or 30 mg/kg BW10+/ND+/+NDSuppressed FAS activity. Activation of FA β-oxidation in liver. The lower dose is more efficient than the higher dose
Zhou et al[108] (2012)Overall transcriptomic and metabolic profilingDIO mice0.04% or 0.02% RSV + quercetin 0.02%26+/ND-/+NDModulation of inflammation and FA β-oxidation. Combination with quercetin was more effective than RSV alone
Jeon et al[51] (2012)Cognitive deficitDIO mice200 mg/kg BW20+/NDNDNDAttenuation of hepatic lipid peroxidation and macrophage infiltration
Shiozaki et al[97] (2012)LongevitySAMP10 mice0.04% RSV20+/NDNDNDInhibition of ACC. Improved mitochon-drial number, redox status and activity
Gao et al[114] (2013)NAFLDT0901317-treated mice200 mg/kg BW< 1+/++/ND+Inhibition of ACC. Unchanged expression SREBP-1c and related genes
Li et al[110] (2013)NAFLDHFS mice50 mg/kg BW3+/ND Decrease in NASHNDNDInhibition of NF-κB-induced inflamma-tion and MDA-induced oxidative stress. Protection against NASH fibrosis
Bujanda et al[49] (2008)NAFLDFasting/feeding special diet, rats10 mg daily4+/-NDNDHepatic TNF-α decrease. Improved oxidant/antioxidant markers (MDA, NOS, SOD, e.g., catalase)
Shang et al[74] (2008)NAFLDHFD rats100 mg/kg BW10+/++/-+Suppressed SREBP-1c and FAS gene expression
Poulsen et al[76] (2012)NAFLDHFD rats100 mg daily8+/-+/ND-Increased UCP2 expression Increased mitochondrial number
Gomez-Zorita et al[103] (2012)NAFLDObese Zucker rats15 mg/kg BW or 45 mg/kg BW6+/++/?NDIncreased CPT-1α and ACO No effect on activity of lipogenic enzymes
Bagul et al[94] (2012)Oxidative stressHigh fructose fed rats10 mg/kg BW8+/NDNDNDAttenuation of hepatic oxidative stress, e.g., with increased level of NRF2
Franco et al[96] (2013)Oxidative stress and NAFLDObese ‘early weaned’ rats30 mg/kg BW4+/ND+/NDNDDecreased markers of oxidative stress
Xin et al[66] (2013)NAFLDHFS rats50 or 100 mg/kg BW13+/ND+/+NDDecreased hepatic LDLr and SRB1 mRNA and protein express
Cho et al[67] (2008)HyperlipidemiaHFD hamsters0.25 g/kg diet8+/++/+NDDecreased HMG-CoA expression and modulated lipoprotein expression
Burgess et al[110] (2011)Metabolic syndromeHFD mini-swine100 mg/kg daily11(+)/NDNDNDImproved insulin sensitivity