Update on inflammatory bowel disease in patients with primary sclerosing cholangitis

Table 1 Characteristics of inflammatory bowel disease associated with primary sclerosing cholangitis

Extensive colitis (with right-sided predominance)

Rectal sparing

Backwash ileitis

Mild or quiescent course

Increased risk of colorectal cancer

Increased risk of pouchitis in patients undergoing proctocolectomy with Ileal pouch anal anastomosis

Increased risk of peristomal varices in patients undergoing proctocolectomy with ileostomy

Table 2 Summary of studies evaluating primary sclerosing cholangitis as a risk factor for colorectal neoplasia in chronic ulcerative colitis

Ref.	UC case group (No)	Centre	End point (No)	Matched controls	Colectomy rate	Is PSC a risk factor?
Broomé et al[45]	Dys (17)	Hudding, Sweden	PSC (5)	Yes	0%	Yes
D’Haens et al[46]	Dys (29)	Chicago, United States	Cholestasis/PSC (10)	Yes	0%	Yes
Broomé et al[47]	PSC (40)	Hudding, Sweden	CRC/Dys (15)	Yes	30%	Yes
Brentnall et al[48]	PSC (20)	Seattle, United States	Dys (9)	No	0%	Yes
Leidenius et al[49]	PSC (45)	Helsinki, Finland	CRC/Dys (13)	Yes	29%	Yes
Marchesa et al[50]	PSC (27)	Clevelan, United States	CRC (4)/Dys (14)	Yes	All postop	Yes
Shetty et al[51]	PSC (132)	Clevelan, United States	CRC (17)/Dys (16)	No	0%	Yes
Loftus et al[52]	PSC (143)	Mayo Clinic, United States	CRC (8)	No	37%	No
Nuako et al[53]	CRC (171)	Mayo Clinic, United States	PSC (30)	Yes	14%	No

CRC: Colorectal cancer; CRN: Colorectal neoplasia; Dys: Dysplasia; PSC: Primary sclerosing cholangitis.