Copyright ©2014 Baishideng Publishing Group Co.
World J Hepatol. Apr 27, 2014; 6(4): 178-187
Published online Apr 27, 2014. doi: 10.4254/wjh.v6.i4.178
Table 1 Characteristics of inflammatory bowel disease associated with primary sclerosing cholangitis
Extensive colitis (with right-sided predominance)
Rectal sparing
Backwash ileitis
Mild or quiescent course
Increased risk of colorectal cancer
Increased risk of pouchitis in patients undergoing proctocolectomy with Ileal pouch anal anastomosis
Increased risk of peristomal varices in patients undergoing proctocolectomy with ileostomy
Table 2 Summary of studies evaluating primary sclerosing cholangitis as a risk factor for colorectal neoplasia in chronic ulcerative colitis
Ref.UC case group (No)CentreEnd point (No)Matched controlsColectomy rateIs PSC a risk factor?
Broomé et al[45]Dys (17)Hudding, SwedenPSC (5)Yes0%Yes
D’Haens et al[46]Dys (29)Chicago, United StatesCholestasis/PSC (10)Yes0%Yes
Broomé et al[47]PSC (40)Hudding, SwedenCRC/Dys (15)Yes30%Yes
Brentnall et al[48]PSC (20)Seattle, United StatesDys (9)No0%Yes
Leidenius et al[49]PSC (45)Helsinki, FinlandCRC/Dys (13)Yes29%Yes
Marchesa et al[50]PSC (27)Clevelan, United StatesCRC (4)/Dys (14)YesAll postopYes
Shetty et al[51]PSC (132)Clevelan, United StatesCRC (17)/Dys (16)No0%Yes
Loftus et al[52]PSC (143)Mayo Clinic, United StatesCRC (8)No37%No
Nuako et al[53]CRC (171)Mayo Clinic, United StatesPSC (30)Yes14%No