Original Article
Copyright ©2014 Baishideng Publishing Group Co.
World J Hepatol. Feb 27, 2014; 6(2): 72-84
Published online Feb 27, 2014. doi: 10.4254/wjh.v6.i2.72
Table 1 Study design
GroupHepatic remnant volumeCold ischemia warm reperfusionShear stress portal hypertension
Control100%, native liver--
60%-hepatectomy40%, native liver-+
100%-OLT100%, syngeneic graft+-
40%-SOLT40%, syngeneic graft++
OLT: Orthotopic liver transplantation; SOLT: Split orthotopic liver transplantation.
Table 2 Statistical differences between groups
Control vs 60%-hepatectomyControl vs 100%-OLTControl vs 40%-SOLT60%-hepatectomy vs 100%-OLT60%-hepatectomy vs 40%-SOLT100%-OLT vs 40%-SOLT
Survival rateP < 0.05NSP < 0.05P < 0.05P < 0.05P < 0.05
Liver damage scoreP < 0.05P < 0.05P < 0.05NSP < 0.05P < 0.05
TUNEL positive ratioP < 0.05P < 0.05P < 0.05P < 0.05P < 0.05P < 0.05
Caspase-3 positive ratioP < 0.05P < 0.05P < 0.05P < 0.05P < 0.05P < 0.05
ASTP < 0.05P < 0.05P < 0.05P < 0.05P < 0.05P < 0.05
ALTP < 0.05P < 0.05P < 0.05P < 0.05P < 0.05NS
T-BilNSNSP < 0.05NSP < 0.05P < 0.05
PT-INRP < 0.05p <0.05P < 0.05P < 0.05P < 0.05P < 0.05
HAP < 0.05p <0.05P < 0.05P < 0.05P < 0.05P < 0.05
Western blotting
MDAP < 0.05P < 0.05P < 0.05NSP < 0.05NS
4-HNEP < 0.05P < 0.05P < 0.05NSNSNS
ATMP < 0.05P < 0.05P < 0.05NSNSNS
γH2AXP < 0.05P < 0.05P < 0.05NSP < 0.05P < 0.05
PI3KP < 0.05NSP < 0.05P < 0.05NSP < 0.05
AktP < 0.05NSP < 0.05P < 0.05NSP < 0.05
SODNSNSNSNSNSNS
CatalaseNSNSNSNSNSNS
MMP-9NSNSP < 0.05NSP < 0.05P < 0.05
MMP-2NSNSP < 0.05NSNSNS
TIMP-1P < 0.05NSP < 0.05P < 0.05NSP < 0.05
TIMP-2NSNSP < 0.05P < 0.05NSP < 0.05
Zymography
MMP-9P < 0.05P < 0.05P < 0.05NSP < 0.05p <0.05
MMP-2NSNSNSNSNSNS
TIMP-1NSNSNSNSNSNS
TIMP-2NSNSNSNSNSNS
OLT: Orthotopic liver transplantation; SOLT: Split orthotopic liver transplantation; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; T-Bil: Total bilirubin; PT-INR: International normalized ratio of prothrombin time; HA: Hyaluronic acid; MDA: Malondialdehyde; 4-HNE: 4-hydroxynonenal; ATM: Ataxia-telangiectasia mutated kinase; PI3K: Phosphatidylinositol 3-kinase; SOD: Superoxide dismutase; MMP: Matrix metalloproteinase; TIMP: Tissue inhibitor of metalloproteinase.