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©2014 Baishideng Publishing Group Inc.
World J Hepatol. Nov 27, 2014; 6(11): 800-811
Published online Nov 27, 2014. doi: 10.4254/wjh.v6.i11.800
Published online Nov 27, 2014. doi: 10.4254/wjh.v6.i11.800
Study | Treatment group | Control group | No. | Study design | Duration (mo) | Histology | Liver enzymes | US |
Life style modification | ||||||||
Huang et al[66] | Diet | - | 12 | Open label | 12 | Improved | - | - |
Ueno et al[65] | Diet/Exercise | Control | 15 | Open label | 3 | Improved | Improved | - |
Pioglitazone (insulin sensitizer) | ||||||||
Promrat et al[71] | Pioglitazone | - | 18 | Open label | 12 | Improved | Improved | - |
Belfort et al[72] | Pioglitazone and Diet | Placebo | 55 | RCT | 6 | Improved | Improved | - |
Aithal et al[73] | Pioglitazone and diet/Exercise | Placebo | 74 | RCT | 12 | Improved | Improved | - |
Sanyal et al[74] | Pioglitazone | Placebo | 163 | RCT | 24 | Improved | Improved | - |
Metformin (insulin sensitizer) | ||||||||
Garinis et al[100] | Metformin and Diet | Diet | 50 | RCT | 6 | - | - | Improved |
Haukeland et al[103] | Metformin | Placebo | 48 | RCT | 6 | - | - | - |
Uygun et al[101] | Metformin and Diet | Control | 50 | Open label | 6 | - | - | Improved |
Bugianes et al[99] | Metformin | Diet | 53 | RCT | 12 | Improved | Improved | - |
Bugianes et al[99] | Metformin | Vitamin E | 57 | RCT | 12 | - | Improved | - |
Vitamin E (antioxidant) | ||||||||
Bugianesi et al[99] | Vitemin E | Diet | 55 | RCT | 12 | - | - | - |
Sanyal et al[74] | Vitamin E | Placebo | 167 | RCT | 24 | Improved | Improved | |
Vajro et al[109] | Vitamin E | Diet | 25 | RCT | 6 | - | - | - |
Other drugs | ||||||||
Sanjay et al[112] | Pentoxifylline | - | 18 | Open label | 6 | - | Improved | - |
Yoneda et al[127] | Ezetimibe | - | 10 | Open label | 6 | Improved | Improved | |
Vasilios et al[118] | Statin | Control | 437 | Open label | 36 | - | Improved | - |
Lindor et al[130] | UDCA | Placebo | 166 | RCT | 48 | - | - | - |
Capani et al[138] | PUFA | Control | 42 | RCT | 12 | - | Improved | Improved |
- Citation: Yoon HJ, Cha BS. Pathogenesis and therapeutic approaches for non-alcoholic fatty liver disease. World J Hepatol 2014; 6(11): 800-811
- URL: https://www.wjgnet.com/1948-5182/full/v6/i11/800.htm
- DOI: https://dx.doi.org/10.4254/wjh.v6.i11.800