Copyright ©2013 Baishideng Publishing Group Co.
World J Hepatol. Sep 27, 2013; 5(9): 479-486
Published online Sep 27, 2013. doi: 10.4254/wjh.v5.i9.479
Table 1 Altered expression of microRNAs in association with Hepatitis C virus infection and liver disease progression
miRNAExpression1Target genesFunction
MiRNAs that facilitates HCV infection
miR-122Up5’ UTR in HCV genomePromote HCV replication[16-18] and IRES mediated HCV translation[21]
Xrn1Inhibit 5’decay of HCV RNA[22]
Cyclin G1Promote Alcohol induced viral replication[27]
SOCS3Enhance methylation at SOCS3 gene promoter, inhibits IFN-induced ISRE activity[41]
miR-130aUpIFITM1Inhibits type 1 IFN signaling pathway and promotes HCV replication[33]
miR-141UpDLC-1Promote viral replication[40]
miR-21UpMyD88 and IRAK1Negatively regulate IFN signaling[42]
MiRNAs that suppresses HCV infection
miR-448UnknownCore region in HCV genomeInhibits viral replication[28]
miR-196/196aUnknownNS5A region in HCV genomeInhibits viral replication[28]
Bach1Inhibits HCV RNA and NS5A protein expression, relieve oxidative stress by upregulating HMOX1 gene expression[31]
let-7bUnknownNS5B and 5’UTR regions in HCV genomeReduces HCV infectivity[29]
miR-199aUnknown5’ UTR in HCV genomeInhibits viral replication[30]
miR-27aUpRXRα and ABCA1Regulates lipid metabolism, decrease viral infectivity[38]
MiRNAs that promote inflammation and fibrosis upon HCV infection
miR-449aDownNOTCH1Regulates YKL40 promoter activity and promotes inflammation[47]
miR-21UpSMAD7Increase TGF-β signaling and promote fibrosis[50]
miR-29DownCOL1A1, COL3A1Potentiate fibrosis by activating hepatic stellate cells[32]
miR-155UpAPCPromote cell proliferation by activating Wnt/β-Catenin signaling pathway[48]