IL-28B polymorphisms and treatment response in hepatitis C virus patients with persistently normal alanine aminotransferase

doi:10.4254/wjh.v5.i11.635

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2013; 5(11): 635-641
Published online Nov 27, 2013. doi: 10.4254/wjh.v5.i11.635

Table 1 Patient baseline and demographic characteristics, and treatment response in the present study

	Total	PNALT	Abnormal ALT	P value
Number of patients	278	100	178
Age (yr)	55.6 ± 11.4	56.2 ± 10.9	55.3 ± 11.6	0.526
Gender (male/female)	136/142	31/69	105/73	< 0.0001
AST (IU/L)	56.6 ± 44.7	29.8 ± 12.1	71.3 ± 49.1	< 0.0001
ALT (IU/L)	70.5 ± 64.3	27.6 ± 7.2	94.6 ± 69.4	< 0.0001
γ-GT (IU/L)	50.7 ± 57.3	26.2 ± 22.1	64.1 ± 65.7	< 0.0001
WBC (/mm³)	5190 ± 1500	5060 ± 1490	5260 ± 1510	0.28
Hemoglobin (g/dL)	14.4 ± 7.1	13.5 ± 1.2	15.0 ± 8.9	0.094
Platelets (× 10⁴/mm³)	17.1 ± 5.6	17.7 ± 5.9	16.8 ± 5.5	0.20
Previous treatment (-/+)	211/67	75/25	136/42	0.90
IL-28B SNP(Maj/Min)	189/89	70/30	119/59	0.68
VR/Null response	203/65	84/16	129/49	0.042
RVR (+/-)	32/200	12/70	20/130	0.93
EVR (+/-)	116/118	46/36	70/82	0.18
SVR (+/-)	143/135	56/44	87/91	0.30

Data are expressed as the mean ± SD. P values are for comparisons between the persistent normal alanine aminotransferase (PNALT)- and abnormal alanine aminotransferase (ALT)-groups by Student’s t-test or χ² test. AST: Aspartate aminotransferase; γ-GT: Gamma-glutamyl transpeptidase; WBC: White blood cell count; IL-28B: Interleukin 28B; SNP: single-nucleotide polymorphisms; Maj: Major genotype; Min: Minor genotype; VR: Virologic response; RVR: Rapid virologic response; EVR: Early virologic response; SVR: Sustained virologic response.

Table 2 Baseline characteristics of hepatitis C virus-infected patients, according to interleukin 28B single-nucleotide polymorphism rs8099917

IL-28B rs8099917	PNALT group (n = 100)			Abnormal ALT group (n = 178)
	Major	Minor	P value	Major	Minor	P value
Number of patients	70	30		119	59
Age (yr)	57.7 ± 10.8	52.6 ± 10.5	0.031	55.3 ± 11.3	55.4 ± 12.3	0.95
Gender (male/female)	21/49	10/20	0.92	68/51	37/22	0.58
AST (IU/L)	29.3 ± 13.1	30.9 ± 9.7	0.58	69.4 ± 51.4	75.4 ± 44.1	0.47
ALT (IU/L)	26.8 ± 7.2	29.5 ± 7.0	0.086	92.1 ± 70.4	99.5 ± 67.8	0.5
γ-GT (IU/L)	21.0 ± 11.5	38.4 ± 33.8	0.00069	54.0 ± 41.3	85.1 ± 95.7	0.0056
WBC (/mm³)	5130 ± 1440	4900 ± 1640	0.52	5280 ± 1,680	5230 ± 1070	0.84
Hemoglobin (g/dL)	13.3 ± 1.0	13.9 ± 1.5	0.02	15.3 ± 10.8	14.4 ± 1.1	0.52
Platelets (× 10⁴/mm³)	17.2 ± 5.7	18.8 ± 6.3	0.21	17.0 ± 5.3	16.4 ± 5.8	0.49
Previous treatment (-/+)	54/16	21/9	0.61	93/26	43/16	0.55
VR/Null response	63/7	21/9	0.027	98/21	31/23	0.000059
RVR (+/-)	9/50	3/20	0.92	17/84	3/46	0.12
EVR (+/-)	38/21	8/15	0.029	59/44	11/38	0.00011
SVR (+/-)	44/26	12/18	0.058	67/52	20/39	0.0079

Data are expressed as the mean ± SD. P values are for comparisons between the major genotype group and minor genotype group among the persistent normal alanine aminotransferase (PNALT) group or among abnormal alanine aminotransferase (ALT) group by Student’s t-test or the χ² test. AST: Aspartate aminotransferase; γ-GT: Gamma-glutamyl transpeptidase; WBC: White blood cell count; IL-28B: Interleukin 28B; Maj: Major genotype; Min: Minor genotype; VR: Virologic response; RVR: Rapid virologic response; EVR: Early virologic response; SVR: Sustained virologic response.

Table 3 Hepatitis C virus genotype 1-infected patient with persistent normal alanine aminotransferase and interleukin 28B single-nucleotide polymorphism

IL-28B rs8099917	Major	Minor	P value	SVR	Non-SVR	P value
Number of patients	54	18		36	36
Age (yr)	58.4 ± 10.9	54.6 ± 11.0	0.20	56.6 ± 13.4	58.4 ± 8.0	0.49
Gender (male/female)	17/37	7/11	0.77	14/22	10/26	0.45
AST (IU/L)	30.3 ± 14.5	34.5 ± 10.3	0.29	13.2 ± 1.1	32.0 ± 6.3	< 0.00010
ALT (IU/L)	27.5 ± 6.7	31.7 ± 5.6	0.019	27.3 ± 7.4	29.8 ± 5.7	0.11
γ-GT (IU/L)	21.7 ± 11.9	47.3 ± 39.3	0.00024	19.7 ± 10.6	39.2 ± 32.7	0.0011
WBC (/mm³)	5020 ± 1410	4570 ± 1350	0.27	5000 ± 1350	4780 ± 1470	0.51
Hemoglobin (g/dL)	13.3 ± 0.9	13.7 ± 1.5	0.17	13.2 ± 1.1	13.5 ± 1.1	0.25
Platelets (× 10⁴/mm³)	16.6 ± 6.0	17.0 ± 5.6	0.80	17.1 ± 6.0	16.2 ± 5.8	0.51
Previous Treatment (-/+)	42/12	12/6	0.52	29/7	25/11	0.41
VR/Null response	46/8	9/9	0.0064	36/0	19/17	< 0.00010
RVR (+/-)	6/38	0/16	0.28	6/27	0/27	0.057
EVR (+/-)	25/19	1/15	0.0013	23/10	3/24	< 0.00010
SVR (+/-)	34/20	2/16	0.00040
IL-28B SNP rs8099917
(Maj/Min)				34/2	20/16	0.00040

Data are expressed as the mean ± SD. P values are for comparisons between the major genotype group and minor genotype group or between sustained virologic response (SVR) and non-SVR groups by Student’s t-test or the χ² test. AST: Aspartate aminotransferase; γ-GT: Gamma-glutamyl transpeptidase; WBC: White blood cell count; IL-28B: Interleukin 28B; Maj: Major genotype; Min: Minor genotype; VR: Virologic response; RVR: Rapid virologic response; EVR: Early virologic response; SVR: Sustained virologic response.

Table 4 Factors associated with sustained virologic response among hepatitis C virus genotype 1-infected patients with persistent normal alanine aminotransferase by multivariate analysis

Factor	Category	Odds ratio	95%CI	P value
IL-28B rs8099917	Major/Minor	7.11	1.305-38.799	0.023
EVR	(+/-)	13.28	3.242-54.399	0.0003

IL-28B: Interleukin 28B; Maj: Major genotype; Min: Minor genotype; EVR: Early virologic response.

Citation: Miyamura T, Kanda T, Nakamura M, Jiang X, Wu S, Nakamoto S, Mikami S, Takada N, Imazeki F, Yokosuka O. IL-28B polymorphisms and treatment response in hepatitis C virus patients with persistently normal alanine aminotransferase. World J Hepatol 2013; 5(11): 635-641
URL: https://www.wjgnet.com/1948-5182/full/v5/i11/635.htm
DOI: https://dx.doi.org/10.4254/wjh.v5.i11.635