Increased bone mineral density in patients with non-alcoholic steatohepatitis

doi:10.4254/wjh.v5.i11.627

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Nov 27, 2013 (publication date) through Feb 15, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Nov 27, 2013; 5(11): 627-634
Published online Nov 27, 2013. doi: 10.4254/wjh.v5.i11.627

Table 1 Demographic features of patients in the non-alcoholic steatohepatitis and in the control group

Parameter	NASH groupmean ± SD(range)	Control groupmean ± SD(range)	P value
n (Female/Male)	13/25	18/24	0.428
Age (yr)	41 ± 12 (18-69)	42.8 ± 10 (24-65)	0.499
Smoking n (%)	10 (26)	9 (26)	0.810
BMI (kg/m²)	29 ± 4 (20-39)	27 ± 5 (21-39)	0.338
Waist (cm)	98 ± 9 ( 77-118)	93 ± 9 (76-113)	0.019

NASH: Non-alcoholic steatohepatitis; BMI: Body mass index.

Table 2 Biochemical findings of the non-alcoholic steatohepatitis and the control group

Parameter	NASH groupmean ± SD (range)	Control groupmean ± SD (range)	P value
Urea (mg/dL)	28 ± 7 (13-52)	29 ± 8 (14-51)	0.631
Creatinine (mg/dL)	0.7 ± 0.1 (0.6-1.1)	0.8 ± 0.1 (0.5-1.1)	0.631
T. cholesterol (mg/dL)	191 ± 42 (104-314)	187 ± 44 (98-296)	0.668
Triglyceride (mg/dL)	208 ± 210 (67-1420)	136 ± 67 (33-298)	0.008
Calcium (mg/dL)	9.5 ± 0.4 (8.6-10.3)	9.4 ± 0.54 (8.6-10.6)	0.239
Phosphorus (mg/dL)	3.4 ± 0.4 (2.1-4.3)	3.6 ± 0.6(2.3-5.7)	0.288
ALT (U/L)	114 ± 115 (51-775)	20 ± 8 (8-36)	< 0.0001
AST (U/L)	55 ± 31 (28-190)	20 ± 7 (2-35)	< 0.0001
ALP (U/L)	93 ± 44 (43-266)	72 ± 18 (44-123)	0.016
GGT (U/L)	121 ± 214 (23-1135)	29 ± 15 (8-65)	< 0.0001
T bilirubin (mg/dL)	0.8 ± 0.6 (0.2-3.2)	0.6 ± 0.3 (0.2-1.5)	0.165
Albumin (g/dL)	4.2 ± 0.5 (2.3-5.1)	4.2 ± 0.3 (3.5-5.1)	0.214
Ferritin (ng/mL)	208 ± 193 (22-901)	75 ± 82 (3-470)	< 0.001

NASH: Non-alcoholic steatohepatitis; AST: Aspartate transaminase; ALT: Alanine transaminase; GGT: Gamma glutamyl transferase; ALP: Alkaline phosphatase.

Table 3 Serum hormone and cytokine results of the non-alcoholic steatohepatitis and the control group

Parameter	NASH groupmean ± SD (range)	Control group mean ± SD (range)	P value
HOMA	5.7 ± 5.25 (1.1-23.59)	5.6 ± 10.1 (0.7-59.9)	0.192
Cortisol (μg/dL)	12.6 ± 5.8 (1.6-27)	11.6 ± 5.8 (2.9-28)	0.375
TSH (uIU/mL)	1.7 ± 1.09 (0.2-5.3)	1.36 ± 1 (0.01-4)	0.104
FT4 (ng/dL)	1.22 ± 0.19 (0.9-1.8)	1.22 ± 0.22 (0.8-107)	0.999
FSH (mIU/mL)	21 ± 41 (1.6-299)	19 ± 37 (0.3-177)	0.729
LH (mIU/mL)	10.4 ± 10.8 (1.2-44)	11 ± 15 (0.1-64)	0.974
E2 (pg/mL)	39.1 ± 72 (3.8-435)	41 ± 47 (2-199)	0.404
DHEAS (ug/dL)	190 ± 109 (25-501)	146 ± 90 (33-366)	0.071
iPTH (pg/mL)	46.3 ± 20 (18-130)	50 ± 16 (19-105)	0.086
25-OH-vit-D3 (ug/L)	17 ± 6 (5.1-39)	13 ± 7 (3.8-36)	< 0.0001
Testosterone (ng/mL)	2.5 ± 1.9 (0.03-5.8)	1.7 ± 1.9 (0.02-5.4)	0.075
IGF-1 (ng/mL)	141 ± 94 (30-527)	144 ± 47 (67-292)	0.099
TNF-α (pg/mL)	11.6 ± 6.7 (4-31.7)	14 ± 7 (2-4.9)	0.062
IL-6 (pg/mL)	2.2 ± 0.6 (2-4.9)	3 ± 2.4 (2-12)	0.8
IL-1 (pg/mL)	8.2 ± 16.5 (5-107)	5.3 ± 2 (5-17)	0.291
IGFBP-3 (ug/mL)	4.1 ± 1.68 (1.1-8.6)	4.2 ± 0.8 (2.6-6.02)	0.909

NASH: Non-alcoholic steatohepatitis; TNF-α: Tumor necrosis factor-α; IL-6: Interleukin-6; IGF-1: Insulin-like growth factor-1; IGFBP-3: Insulin-like growth factor binding protein-3; HOMA: Homeostasis model assessment; TSH: Thyroid stimulating hormone; LH: Luteinizing hormone; E2: Estradiol; DHEAS: Dehydroepiandrostenedione sulfate; iPTH: Intact parathormone; FT4: Free T4; FSH: Follicle-stimulating hormone.

Table 4 Histopathological findings according to Brunt classification of liver biopsy obtained from the non-alcoholic steatohepatitis group n (%)

Parameters	Grade 0	Grade 1	Grade 2	Grade 3
Steatosis	0 (0)	11 (29)	15 (39)	12 (32)
Ballooning	1 (3)	11 (29)	26 (68)	-
Lobular inflammation	0 (0)	21 (55)	16 (42)	1 (3)
Portal inflammation	8 (21)	24 (63)	6 (16)	0 (0)
Fibrosis	12 (32)	18 (47)	3 (8)	5 (13)

Table 5 Dual-energy X-ray absorptiometry results of patients in the non-alcoholic steatohepatitis and the control group

Parameter	NASH groupmean ± SD (range)	Control groupmean ± SD (range)	P value
Lumbar BMD	1.057 ± 0.119	0.941 ± 0.133	0.001
Lumbar T-score	-0.77 ± 1.25 (-2.9-2.6)	-1.58 ± 1.36 (-3.7-2.2)	0.009
Lumbar Z-score	-0.44 ± 1.38 (-3.3-2.9)	-1.18 ± 1.28 (-2.9-2.5)	0.019
Femoral BMD	1.004 ± 0.118	0.972 ± 0.130	0.305
Femoral T-score	0.32 ± 0.87 (-2-1.8)	0.062 ± 1.02 (-1.7-2.1)	0.242
Femoral Z-score	0.65 ± 0.92 (-1.5-2.8)	0.35 ± 0.94 (-1.6-2)	0.178

NASH: Non-alcoholic steatohepatitis; BMD: Bone mineral density.

Citation: Kaya M, Işık D, Beştaş R, Evliyaoğlu O, Akpolat V, Büyükbayram H, Kaplan MA. Increased bone mineral density in patients with non-alcoholic steatohepatitis. World J Hepatol 2013; 5(11): 627-634
URL: https://www.wjgnet.com/1948-5182/full/v5/i11/627.htm
DOI: https://dx.doi.org/10.4254/wjh.v5.i11.627