Treatment strategy for colorectal cancer with resectable synchronous liver metastases: Is any evidence-based strategy possible?

Table 1 Outcome of simultaneous vs staged major liver resections

Author	Year	Patients		Mortality			Morbidity
		SimRes	Del	SimRes (%)	Del (%)	P value	SimRes (%)	Del (%)	P value
Martin et al[15]1	2003	45	76	4	4	NS	60	70	0.03
Thelen et al[22]	2007	15	142	26.7	1.4	0.0007	NR	NR
Reddy et al[18]2	2007	36	291	8.3	1.4	0.03	44.4	26.8	0.04
Capussotti et al[20]1	2007	31	48	3.2	0	NS	32.6	56.3	0.04
de Santibañes et al[23]	2010	42	-	4.7	-	-	37.2	-	-
Luo et al[21]	2010	44	133	NR	NR		56.8	57.1	NS

¹In delayed liver resections, morbidity of both hospitalizations (colorectal surgery and liver surgery) is considered;

²Simultaneous colorectal and major liver resection vs other isolated liver resections.

SimRes: Simultaneous colorectal and major liver resection; Del: Delayed major liver resection; NR: Data not reported; NS: Not significant.

Table 2 Outcome of “Up-front chemotherapy” strategy: risk of emergency surgery while on treatment n (%)

Author	Year	Patients	Resectable at diagnosis	Oxaliplatin- or Irinotecan-based chemotherapy (%)	Emergency surgery
Benoist et al[37]	2005	27	No	67	4 (14.8)
Muratore et al[38]	2007	35	No	100	1 (2.8)
Poultsides et al[39]	2009	233	No	100	16 (7)
Karoui et al[40]	2011	123	No	90	15 (12.1)
Viganò/Capussotti1	2012	40	Yes	100	3 (7.5)

¹Unpublished data.