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©2012 Baishideng Publishing Group Co.
World J Hepatol. Jul 27, 2012; 4(7): 209-217
Published online Jul 27, 2012. doi: 10.4254/wjh.v4.i7.209
Published online Jul 27, 2012. doi: 10.4254/wjh.v4.i7.209
Table 1 Histological characteristics of nonalcoholic steatohepatitis on liver biopsy
Histological finding | n = 32 |
Steatosis | |
Grade 1 | 12 |
Grade 2 | 15 |
Grade 3 | 5 |
Ballooning degeneration | 8 |
Glycogenated nuclei | 11 |
Necroinflammatory activity | |
Grade 1 | 10 |
Grade 2 | 17 |
Grade 3 | 5 |
Staging fibrosis | |
Stage 0 | 11 |
Stage 1 | 14 |
Stage 2 | 4 |
Stage 3 | 3 |
Table 2 Components of metabolic syndrome seen in our patients n = 60 (%) according to National Cholesterol Education Program adult treatment panel III and waist modified by Indian criteria
Components present | NCEP ATP III | Indian criteria |
None | 7 (12) | 1 (2) |
1 | 20 (34) | 13 (22) |
2 | 23 (38) | 24 (40) |
3 | 8 (13) | 18 (30) |
4 | 2 (4) | 4 (7) |
Table 3 Baseline demographic, anthropometric and biochemical characteristics of patients
Characteristic | Non-compliant (n = 15) | Compliant group (n = 45) | P value1 |
Age (yr) | 39.6 ± 8.9 | 40.1 ± 9.0 | NS |
Gender (Males) | 9 | 37 | |
BMI (kg/m2) | 27.6 ± 3.8 | 26.7 ± 3.3 | NS |
< 25 | 6 | 15 | |
25-30 | 6 | 20 | |
> 30 | 3 | 10 | |
WC | 98.0 ± 8.6 | 95.7 ± 8.9 | NS |
Fasting glucose (mg/dL) | 86.4 ± 11.3 | 86.8 ± 14.3 | NS |
2 h glucose (mg/dL) | 128.2 ± 43.5 | 123.5 ± 41.8 | NS |
Serum albumin (g/dL) | 3.9 ± 0.4 | 4.0 ± 0.4 | NS |
AST (U/L) | 78.3 ± 460.2 | 76.2 ± 46.2 | NS |
ALT (U/L) | 82.0 ± 45.0 | 84.8 ± 43.5 | NS |
Total cholesterol (mg/dL) | 202.2 ± 45.0 | 194.6 ± 62.0 | NS |
Triglycerides (mg/dL) | 178.5 ± 102.6 | 186.4 ± 112.5 | NS |
LDL (mg/dL) | 114.5 ± 43.5 | 120.4 ± 56.4 | NS |
HDL (mg/dL) | 38.5 ± 18.5 | 37.4 ± 8.6 | NS |
Table 4 Sub-group analysis of the compliant group - exercise alone and both exercise and diet modification and comparison with non-compliant group
Variable | Non-compliant (n = 15) | Exercise (n = 12) | Exercise and diet (n = 33) | ||||||
Pre | Post | P value1 | Pre | Post | P value1 | Pre | Post | P value1 | |
BMI (kg/m2) | 27.6 ± 3.8 | 27.7 ± 3.5 | NS | 23.0 ± 1.4 | 21.7 ± 1.6 | NS | 28.5 ± 2.4 | 26.6 ± 2.7 | < 0.001 |
WC (cm) | 99.2 ± 7.00 | 98.7 ± 8.4 | NS | 88.0 ± 7.0 | 85.4 ± 7.2 | 0.001 | 99.5 ± 7.2 | 93.6 ± 5.5 | < 0.001 |
WHR | 0.9 ± 0.3 | 0.9 ± 0.1 | NS | 0.9 ± 0.3 | 0.9 ± 0.1 | 0.006 | 0.9 ± 0.6 | 0.9 ± 0.1 | 0.001 |
ALT (U/L) | 82.0 ± 45.0 | 78.2 ± 18.6 | NS | 69.8 ± 32.3 | 34.6 ± 13.1 | 0.001 | 90.3 ± 46.1 | 43.8 ± 19.4 | 0.001 |
HOMA-IR | 8.7 ± 4.1 | 10.5 ± 9.8 | NS | 6.2 ± 4.6 | 1.2 ± 0.8 | 0.002 | 6.5 ± 4.4 | 1.4 ± 1.1 | < 0.001 |
Table 5 Anthropometric, biochemical and histological characteristics of patients with paired liver biopsy (n = 8)
Variable | Pre-intervention | Post-intervention | P value1 |
BMI (kg/m2) | 27.6 ± 3.8 | 26.0 ± 2.4 | 0.012 |
WC (cm) | 96.3 ± 7.6 | 91.0 ± 6.3 | 0.01 |
ALT (U/L) | 99.8 ± 37.2 | 34.0 ± 16.8 | 0.01 |
HOMA-IR | 6.1 ± 3.8 | 1.04 ± 0.5 | 0.01 |
NASH score | 5.3 ± 1.5 | 3.3 ± 1.5 | 0.02 |
Table 6 Correlation between improvement in nonalcoholic steatohepatitis score and anthropometry, biochemical characteristics
Variable | rs | P value1 |
BMI (kg/m2) | 0.62 | 0.05 |
WC (cm) | 0.68 | 0.04 |
ALT (U/L) | 0.54 | 0.05 |
HOMA-IR | 0.73 | 0.03 |
- Citation: Bhat G, Baba CS, Pandey A, Kumari N, Choudhuri G. Life style modification improves insulin resistance and liver histology in patients with non-alcoholic fatty liver disease. World J Hepatol 2012; 4(7): 209-217
- URL: https://www.wjgnet.com/1948-5182/full/v4/i7/209.htm
- DOI: https://dx.doi.org/10.4254/wjh.v4.i7.209