Copyright
©2011 Baishideng Publishing Group Co.
World J Hepatol. Apr 27, 2011; 3(4): 93-98
Published online Apr 27, 2011. doi: 10.4254/wjh.v3.i4.93
Published online Apr 27, 2011. doi: 10.4254/wjh.v3.i4.93
Table 1 Baseline characteristics of patients with primary biliary cirrhosis and controls
Variables | Controls | PBC | P value |
n = 151 | n = 180 | ||
Age (years) | 49.8 (20-72) | 56.3 (22-74) | < 0.001 |
Female gender | 65 (43) | 165 (91.7) | < 0.001 |
Caucasian | 123 (81.5) | 158 (87.8) | 0.1 |
AMA | 0 (0) | 137 (77.8) | |
BMI (kg/m2) | 28 (17-50) | 26.8 (17.6-51) | 0.09 |
Hypertension | 49 (32.5) | 48 (26.8) | 0.3 |
Diabetes | 21 (13.9) | 26 (14.5) | 0.9 |
Smoking | 96 (63.6) | 62 (35) | < 0.001 |
Stage of diseasea | 0.001 | ||
0-2 | 28 (21.1) | 64 (38.6) | |
3-4 | 105 (78.9) | 102 (61.4) | |
Total cholesterol (mg/dL) | 157.5 (73-320) | 216 (81-2055) | < 0.001 |
LDL (mg/dL) | 80 (20-189) | 127 (12–539) | < 0.001 |
HDL (mg/dL) | 48 (20-101) | 54 (17-163) | 0.001 |
Triglyceride (mg/dL) | 117 (19-2334) | 104 (32-736) | 0.2 |
Statin use | 2 (1.3) | 15 (8.3) | 0.004 |
CAD | 8 (5.3) | 14 (7.8) | 0.4 |
TIA | 2 (1.3) | 1 (0.6) | 0.6 |
Stroke | 0 (0) | 3 (1.7) | 0.3 |
Any CVD | 10 (6.6) | 18 (10) | 0.3 |
Table 2 Serum lipid levels in different stages of primary biliary cirrhosis based on the Metavir scoring system
Stage 0-2 | Stage 3-4 | P value | |
Total cholesterol (mg/dL) | 229.5 (129-2055) | 210 (81-612) | 0.3 |
HDL (mg/dL) | 56 (20-102) | 53 (20-163) | 0.4 |
LDL (mg/dL) | 130.5 (52-239) | 127 (12-539) | 0.9 |
Triglyceride (mg/dL) | 128 (47-736) | 98.5 (32-462) | 0.008 |
Table 3 Characteristics of patients with asymptomatic and symptomatic primary biliary cirrhosis
Variables | Asymtomatic | Symptomatic | P value |
n = 66 | n = 114 | ||
Age (years) | 56.7 (31-74) | 56.0 (22-73) | 0.4 |
Female gender | 58 (87.9) | 107 (93.9) | 0.2 |
Caucasian | 60 (90.9) | 98 (86) | 0.3 |
AMA | 50 (78.1) | 87 (77.7) | 1 |
BMI | 26.2 (19-43) | 27 (17.6-51) | 0.4 |
Hypertension | 19 (29.2) | 29 (25.4) | 0.6 |
Diabetes | 12 (18.5) | 14 (12.3) | 0.3 |
Smoking | 18 (28.6) | 44 (38.6) | 0.2 |
Stage of fibrosisa | 0.6 | ||
0-2 | 21 (35.6) | 43 (40.2) | |
3-4 | 38 (64.4) | 64 (59.8) | |
Total cholesterol (mg/dL) | 223.5 (84-2055) | 209.5 (81-612) | 0.06 |
LDL (mg/dL) | 134 (34-505) | 123 (12-539) | 0.2 |
HDL (mg/dL) | 57 (17-163) | 53 (20-118) | 0.5 |
Triglyceride (mg/dL) | 105 (32-527) | 104 (32-736) | 0.6 |
Statin use | 8 (12.1) | 7 (6.1) | 0.2 |
CAD | 3 (4.5) | 11 (9.6) | 0.22 |
TIA | 0 | 1 (0.9) | 1 |
Stroke | 0 (0) | 3 (2.6) | 0.3 |
Any CVD | 3 (4.5) | 15 (13.2) | 0.06 |
Table 4 Characteristics of cases with and without fatigue
With fatigue | Without fatigue | P value | |
n = 74 | n = 104 | ||
Age (years) | 54.3 (22-73) | 57.1 (31-74) | 0.4 |
Female gender | 71 (95.9) | 92 (88.5) | 0.08 |
Caucasian | 63 (85.1) | 93 (89.4) | 0.4 |
AMA | 57 (77) | 79 (78.2) | 0.9 |
BMI (kg/m2) | 27 (17.6-39.2) | 26.2 (17.6-51) | 0.4 |
Hypertension | 18 (24.3) | 29 (28.2) | 0.6 |
Diabetes | 10 (13.5) | 15 (14.6) | 0.8 |
Smoking | 26 (35.1) | 36 (35.6) | 0.9 |
Stage of fibrosisa | 0.7 | ||
0-2 | 26 (37.1) | 38 (40.4) | |
3-4 | 44 (62.9) | 56 (59.6) | |
Total cholesterol (mg/dL) | 203 (83-612) | 217 (81-2055) | 0.06 |
LDL (mg/dL) | 123.5 (29-539) | 131 (12-505) | 0.2 |
HDL (mg/dL) | 55 (20-118) | 54 (17-163) | 0.5 |
Triglyceride (mg/dL) | 110 (32-462) | 104 (32-736) | 0.6 |
Statin use | 6 (8.1) | 9 (8.7) | 0.9 |
CAD | 7 (9.5) | 7 (6.7) | 0.5 |
TIA | 1 (1.4) | 0 (0) | 0.4 |
Stroke | 2 (2.7) | 0 (0) | 0.2 |
Any CVD | 10 (13.5) | 7 (6.7) | 0.1 |
- Citation: Doycheva I, Chen C, Pan JJ, Levy C. Asymptomatic primary biliary cirrhosis is not associated with increased frequency of cardiovascular disease. World J Hepatol 2011; 3(4): 93-98
- URL: https://www.wjgnet.com/1948-5182/full/v3/i4/93.htm
- DOI: https://dx.doi.org/10.4254/wjh.v3.i4.93