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©2011 Baishideng Publishing Group Co.
World J Hepatol. Jan 27, 2011; 3(1): 15-23
Published online Jan 27, 2011. doi: 10.4254/wjh.v3.i1.15
Published online Jan 27, 2011. doi: 10.4254/wjh.v3.i1.15
Table 1 Clinical characteristics of patients with nonalcoholic steatohepatitis-related hepatocellular carcinoma with or without multicentric occurrence
HCC with MO | HCC without MO | |||||||||||
Case | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 |
Age at Dx of NASH | 73 | 81 | 78 | 71 | 68 | 75 | 71 | 80 | 75 | 78 | 81 | 66 |
Gender | F | M | M | F | M | F | M | F | F | M | M | M |
History of BTF | - | - | - | - | - | - | - | + | - | - | - | - |
BMI (kg/m2) | 31.0 | 26.3 | 25.5 | 32.0 | 26.8 | 23.0 | 27.0 | 32.1 | 34.0 | 23.1 | 24.5 | 25.2 |
T2DM | + | + | + | + | - | + | + | - | + | - | - | - |
Hypertension | + | + | + | + | - | - | - | + | + | - | + | + |
Dyslipidemia | - | - | - | + | - | + | + | + | - | + | + | - |
Varices | - | - | - | - | + | - | + | - | + | - | - | - |
Ascites | - | - | - | - | - | - | - | - | - | - | - | - |
AST (IU/L) | 91 | 67 | 43 | 33 | 34 | 43 | 36 | 34 | 43 | 25 | 83 | 78 |
ALT (IU/L) | 46 | 48 | 49 | 21 | 17 | 32 | 22 | 33 | 40 | 20 | 37 | 75 |
γ-GTP (IU/L) | 122 | 129 | 418 | 72 | 30 | 222 | 46 | 67 | 73 | 104 | 360 | 279 |
Total bilirubin (mg/dL) | 1.0 | 0.7 | 0.8 | 1.1 | 1.4 | 1.1 | 1.5 | 0.6 | 1.2 | 0.6 | 0.6 | 0.8 |
Albumin (g/dL) | 3.8 | 3.7 | 3.4 | 2.9 | 3.3 | 4.0 | 2.9 | 4.1 | 3.7 | 3.8 | 3.4 | 4.2 |
Prothrombin time (%) | 53 | 72 | 97 | 62 | 69 | NAa | 59 | 69 | 86 | 75 | 84 | NAa |
Platelet (× 104/μL) | 21.1 | 12.3 | 10.4 | 11.2 | 4.5 | 14.5 | 6.4 | 31.6 | 11.7 | 12.1 | 26.4 | 11.4 |
Child-Pugh score | A | A | A | B | B | -a | B | A | A | A | A | -a |
HBsAg | - | - | - | - | - | - | - | - | - | - | - | - |
Anti-HBc | + | - | - | + | - | - | - | - | + | + | - | + |
Anti-HCV | - | - | - | - | - | - | - | - | - | - | - | - |
Histological features (Classification by Brunt) | ||||||||||||
Grade | 2 | 2 | 2 | 2 | 1 | 2 | 2 | 1 | 1 | 1 | 2 | 2 |
Stage | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 1 | 2 | 4 |
Type of cirrhosis | Mixed | Mixed | Macro | Mixed | Micro | Mixed | Mixed | Mixed | Mixed | - | - | Macro |
AFP (ng/mL) | 11 | 26 | 15 | 25 | 7 | 9 | 3 | 8 757 | 12 | 2 963 | 900 100 | 8 |
DCP (mAU/mL) | 18 | 24 | 20 | 116 | 24 | NAa | 14 | 35 | 907 | 131 | 10 700 | NAa |
Maximum size of HCC (mm) | 35 | 50 | 40 | 28 | 22 | 17 | 50 | 26 | 40 | 40 | 110 | 70 |
Number of HCC | Mul | Mul | Mul | Mul | Mul | Sol | Mul | Sol | Mul | Mul | Mul | Sol |
TNM stage | III | III | III | III | IVA | I | III | II | III | IVB | III | II |
Initial treatment | Ope | TACE | Ope | TACE | TAI | RFA | TACE | TACE | Ope | Chemo | Ope | TAI |
+ RFA | + RFA | + Ope | + RFA | + Ope | ||||||||
Outcome | Alive | Dead | Dead | Alive | Alive | Alive | Alive | Alive | Dead | Dead | Alive | Alive |
Cause of death | - | LR | NLR | - | - | - | - | - | LR | LR | - | - |
Follow-up period after Dx of HCC (days) | 2 599 | 1 706 | 288 | 1 140 | 280 | 1 011 | 687 | 2 198 | 1 525 | 489 | 162 | 330 |
Table 2 Clinical characteristics of patients with nonalcoholic steatohepatitis-related hepatocellular carcinoma with multicentric occurrence in previous and present reports
Table 3 Clinical characteristics of patients with solitary hepatocellular carcinoma related to nonalcoholic steatohepatitis in previous and present reports
Author | Cases | Age older than 70 yr | Gender | Metabolic diseases | Histological features | |||||
M | F | OB | DM | DL | HT | LC | Non-LC | |||
Cotrim et al[21] | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Orikasa et al[22] | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Shimada et al[23] | 4 | 1 | 2 | 2 | 3 | 2 | 1 | 2 | 4 | 0 |
Mori et al[24] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 |
Bullock et al[25] | 2 | 1 | 2 | 0 | 2 | 2 | 0 | 2 | 0 | 2 |
Cuadrado et al[26] | 2 | 1 | 2 | 0 | 2 | 2 | 0 | 0 | 1 | 1 |
Sato et al[27] | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 |
Ichikawa et al[28] | 2 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 2 |
Ikeda et al[29] | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Hai et al[30] | 2 | 1 | 2 | 0 | 2 | 2 | 0 | 1 | 1 | 1 |
Hashizume et al[31] | 7 | 5 | 4 | 3 | 5 | 5 | 6 | 5 | 5 | 2 |
Maeda et al[32] | 3 | 0 | 2 | 1 | NA | NA | NA | NA | 3 | 0 |
Kawada et al[33] | 6 | 4 | 3 | 3 | 2 | 3 | 1 | 4 | 0 | 6 |
Malik et al[34] | 8 | 2 | 6 | 2 | 5 | 6 | NA | 5 | 8 | 0 |
Chagas et al[35] | 4 | 3 | 2 | 2 | 4 | 3 | 1 | NA | 4 | 0 |
Takuma et al[36] | 8 | 5 | 4 | 4 | 4 | 6 | 3 | 6 | 3 | 5 |
Present authors | 3 | 2 | 1 | 2 | 2 | 1 | 2 | 2 | 3 | 0 |
Total | 56 | 26 | 35 | 21 | 36 | 36 | 16 | 29 | 36 | 20 |
(%) | - | (46.4) | (62.5) | (37.5) | (67.9) | (67.9) | (35.6) | (59.2) | (64.3) | (35.7) |
- Citation: Kawai H, Nomoto M, Suda T, Kamimura K, Tsuchiya A, Tamura Y, Yano M, Takamura M, Igarashi M, Wakai T, Yamagiwa S, Matsuda Y, Ohkoshi S, Kurosaki I, Shirai Y, Okada M, Aoyagi Y. Multicentric occurrence of hepatocellular carcinoma with nonalcoholic steatohepatitis. World J Hepatol 2011; 3(1): 15-23
- URL: https://www.wjgnet.com/1948-5182/full/v3/i1/15.htm
- DOI: https://dx.doi.org/10.4254/wjh.v3.i1.15