Prognosis of metastatic splenic hilum lymph node in patients with gastric cancer after total gastrectomy and splenectomy

Table 1 Demographics and clinicopathological data on 191 patients with gastric cancer with respect to No. 10 LN metastasis n (%)

		Metastasis positive	Metastasis negative	Total	P value
		20 (10.5)	171 (89.5)	191 (100)
Gender	Male	14 (70.0)	111 (64.9)	125 (65.4)	0.651
	Female	6 (30.0)	60 (35.1)	66 (34.5)
Age (years)	≤ 60	7 ( 35.0)	107 (62.6)	114 (59.7)	0.017
	> 60	13 (65.0)	64 (37.4)	77 (40.3)
Site	L	1 (5.0)	11 ( 6.4)	12 (6.3)	0.616
	M	9 (45.0)	58 (33.9)	67 (35.1)
	U	10 (50.0)	102 (59.6)	112 (58.6)
Number of site	1	5 (25.0)	41 (24.0)	46 (24.1)	0.008
	2	7 (35.0)	78 (45.6)	85 (44.5)
	≤ 3	8 (40.0)	52 (30.4)	60 (31.4)
Location	Less	0 ( 0.0)	73 (42.7)	73 (38.2)	< 0.001
	Ant	1 (5.0)	15 (8.8)	16 (8.4)
	Post	3 (15.0)	32 (18.7)	35 (18.3)
	Great	8 (40.0)	13 (7.6)	21 (11.0)
	Cir	8 (40.0)	38 (22.2)	46 (24.1)
Number of location	1	7 (35.0)	90 (52.6)	97 (50.8)	0.200
	2	2 (10.0)	28 (16.4)	30 (15.7)
	3	3 (15.0)	15 (8.8)	18 (9.4)
	4	8 (40.0)	38 (22.2)	46 (24.1)
Tumor size (mm)	≤ 100	11 (55.0)	65 (38.0)	76 (39.8)	0.142
	> 100	9 (45.0)	106 (62.0)	115 (60.2)
Macroscopic type	0	2 (10.0)	13 (7.6)	15 (7.9)	0.503
	1	1 (5.0)	5 (2.9)	6 (3.1)
	2	2 (10.0)	44 (25.7)	46 (24.1)
	3	10 (50.0)	69 (40.4)	79 (41.4)
	4	5 (25.0)	30 (17.5)	35 (18.3)
	5	0 (0.0)	10 (5.8)	10 (5.2)
Histological type	Differentiat	3 (15.0)	53 (31.0)	56 (29.3)	0.137
	Undifferentiated	17 (85.0)	118 (69.0)	135 (70.7)
Depth	M, SM	1 (5.0)	10 (5.8)	11 (5.6)	0.020
	MP	0 (0.0)	12 (7.0)	12 (6.3)
	SS	2 (10.0)	17 (9.9)	19 (9.9)
	SE	9 (45.0)	111 (64.9)	120 (62.8)
	SI	8 (40.0)	21 (12.3)	29 (15.2)
Ly	0, 1	1 (5.0)	48 (28.1)	49 (25.7)	0.025
	2, 3	19 (95.0)	123 (71.9)	142 (74.3)
V	-	2 (10.0)	50 (29.2)	52 (27.2)	0.067
	+	18 (90.0)	121 (70.8)	139 (72.8)
Stromal volume	Med	3 (15.0)	60 (35.1)	63 (33.0)	0.147
	Int	8 (40.0)	62 (36.3)	70 (36.6)
	Sci	9 (45.0)	49 (28.7)	58 (30.4)
INF	α	1 (5.0)	42 (24.6)	43 (22.5)	0.127
	β	6 (30.0)	47 (27.5)	53 (27.7)
	γ	13 (65.0)	82 (48.0)	95 (49.7)
N	0	0 (0.0)	60 (35.1)	60 (31.4)	< 0.001
	1	2 (10.0)	50 (29.2)	52 (27.2)
	2	12 (60.0)	40 (23.4)	52 (27.2)
	3	6 (30.0)	18 (10.5)	24 (12.6)
	M	0 (0.0)	3 (1.8)	3 (1.6)
Number of N	0	0 (0.0)	60 (35.1)	60 (31.4)	0.003
	1-6	7 (35.0)	55 (32.2)	62 (32.5)
	7-15	6 (30.0)	34 (19.9)	40 (20.9)
	16-	7 (35.0)	22 (12.9)	29 (15.2)
Stage	IA,IB	0 (0.0)	25 (14.6)	25 (13.1)	< 0.001
	II	1 (5.0)	39 (22.8)	40 (20.9)
	IIIA	1 (5.0)	45 (26.3)	46 (24.1)
	IIIB	4 (20.0)	35 (20.5)	39 (20.4)
	IV	14 (70.0)	27 (15.8)	41 (21.5)

Various clinicopathological factors, including gender, age, site, the number of sites (Number of sites), location, the number of locations (Number of locations), tumor size, macroscopic type, and histological type were evaluated for any independent contributions to No. 10 LN metastasis, depth of invasion (Depth), invasion of lymph vessel (Ly), venous invasion (V), stromal volume, pattern of tumor infiltration (INF), N factor (N), the number of lymph nodes with positive metastasis (Number of N), and stage using the χ² test. Age, Number of sites, Location, Depth, Ly, N, Number of N, and Stage were found to differ significantly between the Positive Group and the Negative Group (P = 0.017, P = 0.008, P < 0.001, P = 0.017, P = 0.008, P < 0.001, P = 0.003, and P < 0.001, respectively).

Table 2 Logistic regression analysis of clinicopathological data for No. 10 LN metastasis

Parameters	Disease progression
	OR	95% CI	P value
Age (yr)	2.697	0.852-8.538	0.092
Depth	0.636	0.264-1.532	0.313
Ly	2.269	0.220-23.407	0.491
N	0.801	0.277-2.319	0.683
Number of N	1.062	0.446-2.531	0.892
Stage	4.840	1.576-14.864	0.006
Number of sites	0.541	0.246-1.191	0.127
Location	2.027	1.269-3.238	0.003

A logistic regression analysis was conducted for eight parameters (Age, Number of sites, Location, Depth, Ly, N, Number of N, and Stage) that had been found to be significant using the χ² test. A logistic regression analysis showed that the location and Stage were each significant parameter of No. 10 LN metastasis (P = 0.003 and P = 0.006, respectively).

Table 3 Demographics and LN metastasis in 191 patients with gastric cancer with respect to No. 10 LN metastasis n (%)

	Metastasis positive	Metastasis negative	Total	P value
No. 1	8 (40.0)	41 (24.0)	49 (25.7)	0.121
No. 2	11 (55.0)	28 (16.4)	39 (20.4)	< 0.001
No. 3	18 (90.0)	87 (50.9)	105 (55.0)	0.001
No. 4sa	12 (60.0)	10 (5.8)	22 (11.5)	< 0.001
No. 4sb	10 (50.0)	16 (9.4)	26 (13.6)	< 0.001
No. 4d	12 (60.0)	34 (19.9)	46 (24.1)	< 0.001
No. 5	1 (5.0)	10 (5.8)	11 (5.8)	0.878
No. 6	4 (20.0)	19 (11.1)	23 (12.0)	0.248
No. 7	10 (50.0)	43 (25.1)	53 (27.7)	0.019
No. 8a	5 (25.0)	19 (11.1)	24 (12.6)	0.076
No. 8p	1 (5.0)	8 (4.7)	9 (4.7)	0.949
No. 9	2 (10.0)	13 (7.6)	15 (7.9)	0.706
No. 11	11 (55.0)	19 (11.1)	30 (15.7)	< 0.001
No. 12a	0 (0.0)	3 (1.8)	3 (1.6)	0.550
No. 12b	1 (5.0)	2 (1.2)	3 (1.6)	0.192
No. 12p	0 (0.0)	3 (1.8)	3 (1.6)	0.550
No. 13	1 (5.0)	1 (0.6)	2 (1.0)	0.066
No. 14v	1 (5.0)	3 (1.8)	4 (2.1)	0.337
No. 16	4 (20.0)	16 (9.4)	20 (10.5)	0.141
Etc.	0 (0.0)	4 (2.3)	4 (2.1)	0.48

Lymph node metastasis was evaluated for any independent contribution to No. 10 LN metastasis, using the χ² test. The numbers of No. 2, No. 3, No. 4sa, No. 4sb, No. 4d , No. 7, and No. 11 LN metastasis were found to differ significantly between the Positive Group and the Negative Group (P < 0.001, P = 0.001, P < 0.001, P < 0.001, P < 0.001, P = 0.019, and P < 0.001, respectively).

Table 4 Logistic regression analysis of LN metastasis for No. 10 LN metastasis

Parameters	Disease progression
	OR	95% CI	P value
No. 2	0.791	0.181-3.452	0.755
No. 3	1.414	0.219-9.117	0.716
No. 4sa	18.377	4.071-82.962	< 0.001
No. 4sb	8.447	1.844-38.688	0.006
No. 4d	1.098	0.267-4.518	0.897
No. 7	1.085	0.277-4.253	0.907
No. 11	10.096	2.320-43.941	0.002

Significant lymph nodes were extracted for further analysis, carried out using a logistic regression method. A logistic regression analysis showed that No. 4sa, No. 4sb, and No. 11 LN metastasis were each significant parameters for No. 10 LN metastasis (P < 0.001, P = 0.006, and P = 0.002, respectively).