Global landscape of hepatic organoid research: A bibliometric and visual study

Table 1 Top 10 journals contributing to publications in hepatic organoid research

Rank	Journal title	Country	Count	Percent	Impact factor 2023
1	Hepatology	United States	29	2.93%	13.5
2	Scientific Reports	England	28	2.83%	4.6
3	Nature Communications	England	27	2.73%	16.6
4	Biomaterials	Netherlands	26	2.62%	14.0
5	International Journal of Molecular Sciences	United States	21	2.12%	5.6
6	Journal of Hepatology	Netherlands	21	2.12%	25.7
7	Gastroenterology	United States	20	2.02%	29.4
8	Cells	Switzerland	17	1.72%	6.0
9	Plos One	United States	15	1.51%	3.7
10	Advanced Science	United State	14	1.41%	15.1

Table 2 Top 10 countries and institutes contributing to publications in hepatic organoid research

Rank	Country/region	Count	Institute	Count
1	United States	363	Utrecht University	82
2	China	243	Erasmus MC	65
3	Netherlands	156	Hubrecht Institute (KNAW)	57
4	Germany	140	Royal Netherlands Academy of Arts and Sciences	57
5	Japan	124	Chinese Academy of Sciences	41
6	England	74	University of California System	36
7	South Korea	60	University System of Ohio	34
8	Italy	59	Harvard University	32
9	Spain	39	Helmholtz Association	31
10	France	39	Cincinnati Children's Hospital Medical Center	30

Table 3 Top 10 most cited scholars in the hepatic organoid field

Rank	Author	Citations	Country	Institute	Centrality
1	Huch M	275	England	University of Cambridge	0.12
2	Sato T	239	Japan	Keio University	0.10
3	Broutier L	200	England	University of Cambridge	0.07
4	Takebe T	171	United States	Cincinnati Children's Hospital Medical Center	0.09
5	Lancaster MA	125	Austria	Austrian Academy of Sciences	0.05
6	Clevers H	96	Netherlands	Utrecht University	0.02
7	Barker N	93	England	The University of Edinburgh	0.08
8	Hu HL	88	China	Shandong University	0.02
9	Fotios S	86	England	University of Cambridge	0.06
10	Van de wetering M	70	Netherlands	Princess Maxima Center for Pediatric Oncology	0.07

Table 4 Top 10 cocited references and main findings in hepatic organoid research

Rank	Ref.	Count	Main findings
1	Huch M et al[25], 2015, Cell, volume 160	100	Established a long-term and stable human liver organoid culture condition, in which liver organoid can differentiate to functional hepatocytes and model liver disease
2	Hu HL et al[26], 2018, Cell, volume 175	82	Establishment of a long-term 3D organoid culture system for mouse and human primary hepatocytes from single hepatocytes, while retaining key morphological, functional and gene expression features
3	Broutier L et al[27], 2017, Nature Medicine, volume 23	79	Extend the culture system to the propagation of primary liver cancer organoids from three of the most common primary liver cancer subtypes
4	Broutier L et al[23], 2016, Nature Protocols, volume 11	78	Developed culture conditions for self-renewing 3D organoids that allow the long-term expansion of adult primary tissues from human and mouse adult liver and pancreas
5	Ouchi R et al[28], 2019, Cell Metabolism, volume 30	55	Developed a reproducible method to derive multi-cellular human liver organoids composed of hepatocyte-, stellate-, and Kupffer-like cells that exhibit transcriptomic resemblance to in vivo-derived tissues
6	Clevers H[4], 2016, Cell, volume 165	47	Reviewed the organoid applications in modeling human organ development and pathologies as well as personalized medicine
7	Huch M et al[29], 2013, Nature, volume 494	44	Lgr5+ stem cells in actively self-renewing tissues can also be extended to damage-induced stem cells in a tissue with a low rate of spontaneous
8	Van de Wetering M et al[30], 2015, Cell, volume 161	42	Established the tumor organoid cultures from 20 consecutive colorectal carcinoma patients
9	Takebe T et al[31], 2013, Nature, volume 499	42	This is the first report demonstrating the generation of a functional human liver organ from pluripotent stem cells
10	Boj SF et al[32], 2015, Cell, volume 160	39	Generated the pancreatic cancer-derived organoids and revealed that they are suitable for ductal pancreatic cancer research

3D: Three-dimensional.