Hotspots and trends in stem cell therapy for liver fibrosis and cirrhosis: A bibliometric analysis

Table 1 Most prolific authors

Rank	Author	Articles	H-index	Total citations
1	Shuji Terai	22	17	668
2	Isao Sakaida	19	14	388
3	Lanjuan Li	15	11	370
4	Soon Koo Baik	12	11	845
5	Naoki Yamamoto	10	7	195
6	Hossein Baharvand	9	9	643
7	Moon Young Kim	9	9	520
8	Taro Takami	8	7	174
9	Massoud Vosough	8	5	140
10	Yingan Jiang	7	3	27

Table 2 Top 10 productive countries and institutions

Rank	Country	Articles	Centrality	Institution	Articles	Centrality
1	China	463	0.06	Cairo University	63	0.13
2	United States	152	0.06	Zhejiang University	43	0.08
3	Japan	122	0.08	Yamaguchi University	25	0.02
4	South Korea	76	0.06	Air Force Military Medical University	20	0
5	Egypt	63	0.11	Sun Yat-sen University	20	0.02
6	Italy	59	0.24	Capital Medical University	18	0.02
7	Iran	57	0	Chinese Academy of Sciences	17	0.05
8	India	50	0.58	Academic Center for Education, Culture & Research	17	0.04
9	England	43	0.56	Chinese Academy of Medical Sciences - Peking Union Medical College	16	0.04
10	Germany	41	0.47	University of London	15	0.31

Table 3 Major clusters of co-cited references

Cluster ID	Size	Silhouette	Mean year	Label (LLR)
0	172	0.825	2013	Cell-based therapy
1	164	0.833	2007	Tetrachloride-induced liver fibrosis model
2	162	0.743	2017	Mesenchymal stem cell therapy
3	132	0.792	2009	Liver fibrosis
4	119	0.902	2018	Extracellular vesicle
5	95	0.937	2003	Hepatic fibrogenesis
6	69	0.896	2021	Drugs intervention
7	23	0.983	2017	Severe alcoholic hepatitis
8	22	0.991	2002	Systemic infusion
9	18	0.967	2017	Cellular mechanism
10	14	0.977	2010	Thioacetamide-induced cirrhotic rat model

LLR: Log-likelihood ratio.

Table 4 Top 20 most frequent keywords

Rank	Count	High frequency keyword	Year	Centrality
1	411	Mesenchymal stromal cell	2004	0.04
2	368	Liver fibrosis	2004	0.04
3	360	Cirrhosis	2005	0
4	322	Transplantation	2005	0.04
5	270	Stem cell	2005	0.01
6	211	Differentiation	2004	0.1
7	190	Hepatic stellate cell	2006	0.01
8	184	Stromal cells	2008	0
9	179	Bone marrow	2005	0
10	176	Therapy	2004	0.13
11	164	Fibrosis	2008	0
12	159	Expression	2004	0.06
13	146	Regeneration	2004	0.04
14	135	Cell therapy	2006	0.02
15	122	In vitro	2006	0.09
16	117	Mouse	2006	0
17	110	Progenitor cells	2006	0.01
18	106	Injury	2011	0
19	104	Disease	2006	0.05
20	102	Hepatocytes	2004	0.09