Impact of liver cirrhosis on morbidity and mortality of patients admitted to the hospital with necrotizing fasciitis

Table 1 Baseline demographic and clinical characteristics, n (%)

Characteristics	Without cirrhosis	With cirrhosis	P value
Total	14605 (98)	315 (2)
Female	6718 (85)	104 (15)	0.03
Mean age, years	52.7	52.3
Charlson comorbidity index score			< 0.01
0	3651 (25)	0 (0)
1	3943 (27)	69 (22)
2	2774 (19)	66 (21)
≥ 3	4235 (29)	179 (57)
Insurance type			0.73
Medicare	4673 (32)	94 (30)
Medicaid	4527 (31)	116 (37)
Private insurance	3943 (27)	81 (26)
Self-pay	1460 (10)	22 (7)
Comorbidities
Sepsis	2190 (15)	69 (22)	0.14
Diabetes mellitus	8032 (40)	126 (55)	0.015
Hypertension	8470 (58)	176 (56)	0.67
Obesity	5257 (36)	110 (35)	0.88
Chronic kidney disease	1898 (13)	78 (25)	< 0.01
Alcohol use disorder	438 (3)	75 (24)	< 0.01
Chronic obstructive pulmonary disease	1460 (10)	53 (17)	0.5
Chronic heart failure	730 (5)	9 (3)	0.45
Coronary artery disease	1898 (13)	40 (13)	0.38
Gastroesophageal reflux disease	1898 (13)	53 (17)	0.38
Cigarette smoking	4089 (28)	113 (36)	0.13

Table 2 Primary and secondary in-hospital outcomes of cirrhotic vs non-cirrhotic patients, n (%)

Total	Without cirrhosis	With cirrhosis	P value	Adjusted odds ratio1	P value	Confidence interval
In-hospital mortality rates and odds
460 (3)	430 (3)	30 (9.5)	< 0.01	3.78	0.02	1.23-11.5
In-hospital septic shock rates and odds
200 (5)	715 (4.9)	33 (10.5)	0.26	25.6	< 0.01	4.13-159.4
In-hospital surgical amputation rates and odds
1105 (7.4)	1066 (7.3)	30 (9.5)	0.5	1.15	0.77	0.43-3.08

¹Adjusted for age, sex, race, Charlson comorbidity index, insurance status, sepsis, hypertension, obesity, chronic kidney disease, chronic obstructive pulmonary disease, asthma, coronary artery disease, chronic heart failure, smoking status, dementia, supraventricular tachycardia, current long-term insulin use, and gastroesophageal reflux disease.

Table 3 In hospital lengths of stay and charges in cirrhotic vs non-cirrhotic patients

Without cirrhosis	With cirrhosis	Adjusted means	P value
Length of stay means and adjusted means, days1
12.2	16.8	1.11	0.5
Total charges and adjusted means, dollars
152169	237775	46152	0.29

¹Adjusted for age, sex, race, Charlson comorbidity index, insurance status, sepsis, hypertension, obesity, chronic kidney disease, chronic obstructive pulmonary disease, asthma, coronary artery disease, chronic heart failure, smoking status, dementia, supraventricular tachycardia, current long-term insulin use, and gastroesophageal reflux disease.