Comparison of different severity scores in correlating hemoglobin levels with the severity of hepatic decompensation: An observational study

Table 1 Child-Pugh score

Variable	1 point	2 points	3 points	Interpretation
Serum albumin (mg/dL)	> 3.5	2.8–3.5	< 2.8	Sum of points: 5–6 = A; 7–9 = B; > 9 = C
Serum bilirubin (mg/dL)	< 2	2–3	> 3
International normalized ratio	< 1.7	1.7–2.3	> 2.3
Ascites	None	Mild	Marked
Encephalopathy	None	Grade 1 and 2	Grade 3 and 4

Table 2 Interpretation of model of end-stage liver disease score

Model of end-stage liver disease score	3 months mortality (percentage)
9 or less	1.9
10–19	6
20–29	19.6
30–39	52.6
40 or above	71.3

Table 3 Demographic and clinical characteristics of study population

Variable	Number	Mean (SD)	Percentage	Minimum	Maximum
Age	-	58.8 (17.4)	-	15	90
Gender	Male = 405, female = 247	-	62.1, 37.9	-	-
Serum sodium (mEq/L)	-	128.8 (6.2)	-	120	149
Serum bilirubin (mg/dL)	-	5.6 (5.0)	-	0.8	25.3
Serum albumin (mg/dL)	-	3.0 (0.9)	-	1.2	4.9
Serum creatinine (mg/dL)	-	2.1 (1.1)	-	0.6	5.0
International normalized ratio	-	1.9 (0.7)	-	1.1	6.4
Hemoglobin (g/dL)	-	11.1 (2.1)	-	5.3	17.2
Child-Pugh score	-	10.5 (2.6)	-	6	15
MELD score	-	23 (9)	-	5	48
MELD-Na score	-	27 (9)	-	1	49

MELD: Model of end-stage liver disease.

Table 4 Comparison of hemoglobin levels across Child-Pugh classes

Child-Pugh class	Number of patients	Mean hemoglobin (g/dL)	SD (g/dL)	Analysis of variance (F value)	P value
A	41	11.8	2.1	20.011	0.001
B	211	11.7	1.9
C	400	10.6	2.1
Total	652	11.1	2.1

Table 5 Comparison of hemoglobin levels across model of end-stage liver disease score group

Group	Model of end-stage liver disease score range	Number of patients	Mean hemoglobin level (g/dL)	SD (g/dL)	Analysis of variance (F value)	P value
1	< 10	33	12.6	1.8	13.042	0.001
2	10–19	236	11.5	2.0
3	20–29	165	10.7	2.0
4	30–39	181	10.7	1.9
5	> 39	37	9.8	1.9
	Total	652	11.1	2.0

Table 6 Comparison of hemoglobin levels across model of end-stage liver disease-Na score groups

Group	Model of end-stage liver disease-Na score range	Number of patients	Mean hemoglobin level (g/dL)	SD (g/dL)	Analysis of variance (F value)	P value
1	< 10	22	12.0	2.1	9.6	.001
2	10-19	119	11.5	2.0
3	20-29	192	11.4	2.1
4	30–39	274	10.7	1.9
5	> 39	45	10.1	1.9
	Total	652	11.1	2.0

Table 7 Correlation of hemoglobin levels with clinical severity scores (Child-Pugh, model of end-stage liver disease, and model of end-stage liver disease-Na)

Correlation (Pearson)	R value	P value
Hemoglobin vs Child-Pugh	-0.21	< 0.01
Hemoglobin vs MELD	-0.26	< 0.01
Hemoglobin vs MELD-Na	-0.25	< 0.01

MELD: Model of end-stage liver disease.