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©The Author(s) 2024.
World J Hepatol. Aug 27, 2024; 16(8): 1156-1166
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1156
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1156
Table 1 Number of single-nucleotide polymorphisms screened in each step
ID exposure | Panel | Immune traits | Number of SNPs after LD | Number of SNPs after F > 10 | Number of final IVs |
Ebi-a-GCST90001433 | B cell | IgD- CD27-% lymphocyte | 18 | 18 | 18 |
Ebi-a-GCST90001706 | B cell | BAFF-R on IgD + CD38- naive | 29 | 29 | 28 |
Ebi-a-GCST90001762 | B cell | CD20 on IgD + | 23 | 23 | 19 |
Ebi-a-GCST90001790 | B cell | CD25 on memory B cell | 27 | 27 | 24 |
Ebi-a-GCST90001830 | B cell | BAFF-R on CD20- | 14 | 14 | 14 |
Ebi-a-GCST90001793 | B cell | CD25 on sw mem | 21 | 21 | 20 |
Ebi-a-GCST90001809 | B cell | CD38 on CD20- | 20 | 20 | 19 |
Ebi-a-GCST90002110 | Myeloid cell | HLA DR on CD33dim HLA DR + CD11b + | 24 | 24 | 23 |
Ebi-a-GCST90001954 | Myeloid cell | CD33 on basophil | 23 | 23 | 22 |
Ebi-a-GCST90001952 | Myeloid cell | CD33 on Mo MDSC | 21 | 21 | 21 |
Ebi-a-GCST90001951 | Myeloid cell | CD33 on CD66b + + myeloid cell | 19 | 19 | 18 |
Ebi-a-GCST90001521 | Myeloid cell | CD33 bright HLA DR + CD14 dim% CD33 bright HLA DR + | 26 | 26 | 25 |
Ebi-a-GCST90001953 | Myeloid cell | CD33 on CD33 dim HLA DR- | 21 | 21 | 19 |
Ebi-a-GCST90001955 | Myeloid cell | CD33 on Im MDSC | 25 | 25 | 22 |
Ebi-a-GCST90002031 | Treg | CD39 on CD39 + secreting Treg | 24 | 24 | 23 |
Ebi-a-GCST90001901 | Treg | CD28 on CD39 + resting Treg | 23 | 23 | 22 |
Ebi-a-GCST90001688 | Treg | CD28 + CD45 RA + CD8 bright% T cell | 112 | 91 | 88 |
Ebi-a-GCST90001630 | TBNK | CD8 bright NKT AC | 27 | 27 | 26 |
Ebi-a-GCST90002076 | TBNK | SSC-A on NK | 24 | 24 | 23 |
Ebi-a-GCST90002014 | cDC | CCR2 on CD62 L + myeloid DC | 15 | 15 | 14 |
Table 2 Forward mendelian randomization sensitivity analysis
Exposure panel | Exposure traits | Inverse variance weighted | MR-Egger | ||
Q value | P value | Intercept | P value | ||
B cell | IgD- CD27-% lymphocyte | 11.20 | 0.846 | 0.008 | 0.707 |
B cell | BAFF-R on IgD+ CD38- naive | 19.98 | 0.831 | 0.002 | 0.880 |
B cell | CD20 on IgD+ | 18.76 | 0.407 | -0.004 | 0.662 |
B cell | CD25 on memory B cell | 21.52 | 0.549 | -0.002 | 0.854 |
B cell | BAFF-R on CD20- | 9.74 | 0.715 | -0.005 | 0.795 |
B cell | CD25 on sw mem | 17.72 | 0.541 | 0.004 | 0.771 |
B cell | CD38 on CD20- | 14.73 | 0.680 | 0.012 | 0.521 |
Myeloid cell | HLA DR on CD33dim HLA DR+ CD11b+ | 25.66 | 0.266 | -0.011 | 0.303 |
Myeloid cell | CD33 on basophil | 29.56 | 0.101 | 0.014 | 0.248 |
Myeloid cell | CD33 on Mo MDSC | 23.26 | 0.276 | -0.007 | 0.490 |
Myeloid cell | CD33 on CD66b+ myeloid cell | 18.20 | 0.376 | -0.029 | 0.065 |
Myeloid cell | CD33 bright HLA DR+ CD14 dim% CD33 bright HLA DR+ | 29.63 | 0.197 | 0.011 | 0.294 |
Myeloid cell | CD33 on CD33 dim HLA DR- | 18.45 | 0.427 | 0.018 | 0.184 |
Myeloid cell | CD33 on Im MDSC | 30.80 | 0.077 | 0.013 | 0.354 |
Treg | CD39 on CD39+ secreting Treg | 10.76 | 0.978 | -0.005 | 0.554 |
Treg | CD28 on CD39+ resting Treg | 21.59 | 0.423 | 0.013 | 0.220 |
Treg | CD28+ CD45 RA+ CD8 bright% T cell | 80.46 | 0.676 | 0.009 | 0.252 |
TBNK | CD8 bright NKT AC | 25.19 | 0.452 | -0.014 | 0.225 |
TBNK | SSC-A on NK | 27.35 | 0.198 | 0.004 | 0.771 |
cDC | CCR2 on CD62L+ myeloid DC | 9.06 | 0.768 | 0.011 | 0.547 |
Table 3 Number of Single-nucleotide polymorphisms screened in each step
ID exposure | Number of SNPs after LD | Number of SNPs after F > 10 | Number of final IVs |
Finn-b-CIRRHOSIS_BROAD | 31 | 31 | 31 |
Table 4 Reverse mendelian randomization sensitivity analysis
Outcome panel | Outcome traits | Inverse variance weighted | MR-Egger | ||
Q value | P value | intercept | P value | ||
B cell | IgD+ CD38 bright AC | 35.51 | 0.224 | -0.014 | 0.401 |
B cell | IgD+ CD38 dim AC | 30.73 | 0.429 | -0.030 | 0.068 |
B cell | IgD+ AC | 33.15 | 0.316 | -0.028 | 0.094 |
B cell | Naive-mature B cell AC | 27.47 | 0.599 | -0.022 | 0.160 |
B cell | IgD+ CD24- AC | 29.82 | 0.475 | -0.019 | 0.250 |
cDC | CD62L- plasmacytoid DC AC | 29.39 | 0.497 | 0.029 | 0.075 |
Myeloid cell | Im MDSC AC | 29.23 | 0.506 | 0.019 | 0.249 |
Myeloid cell | Im MDSC% CD33 dim HLA DR- CD66b- | 24.09 | 0.768 | 0.009 | 0.568 |
Myeloid cell | CD33- HLA DR+ AC | 30.39 | 0.446 | -0.004 | 0.790 |
TBNK | CD4+% leukocyte | 16.12 | 0.982 | 0.007 | 0.670 |
TBNK | CD3- lymphocyte% leukocyte | 17.10 | 0.971 | 0.013 | 0.443 |
Treg | CD28+ CD45RA- CD8 dim AC | 37.39 | 0.166 | 0.000 | 0.997 |
B cell | CD20 on CD24+ CD27+ | 22.52 | 0.834 | 0.026 | 0.231 |
B cell | CD20 on sw mem | 32.59 | 0.341 | 0.020 | 0.381 |
TBNK | FSC-A on B cell | 25.61 | 0.695 | 0.017 | 0.345 |
Monocyte | CX3CR1 on monocyte | 39.69 | 0.111 | 0.002 | 0.891 |
Monocyte | CX3CR1 on CD14- CD16+ monocyte | 19.80 | 0.922 | 0.008 | 0.641 |
TBNK | SSC-A on B cell | 32.70 | 0.336 | -0.003 | 0.844 |
Treg | CD8 on CD28- CD8 bright | 37.59 | 0.106 | -0.003 | 0.877 |
- Citation: Li Y, Quan X, Tai Y, Wu YT, Wei B, Wu H. Causal association between 731 immunocyte phenotypes and liver cirrhosis: A bidirectional two-sample mendelian randomization analysis. World J Hepatol 2024; 16(8): 1156-1166
- URL: https://www.wjgnet.com/1948-5182/full/v16/i8/1156.htm
- DOI: https://dx.doi.org/10.4254/wjh.v16.i8.1156