Lipophagy and epigenetic alterations are related to metabolic dysfunction-associated steatotic liver disease progression in an experimental model

Table 1 Correlations between circulating microRNAs and gene expression of hepatic lipophagy

Variables		mRNAs				Gene expression of hepatic lipophagy
		miR-375	miR-21	miR-26b	miR-155	p62/Sqstm1	Rubicon	Cd36	Tfeb	Plin2	Plin3	Plin5	Lamp2	Sirt1
miRNAs	miR-34a	0.245	0.573a	0.303	-0.105	-0.389	-0.002	0.480a	0.470a	0.455	0.159	0.317	0.075	-0.397
	miR-375		0.111	0.220	0.196	0.040	0.086	-0.091	-0.008	-0.107	-0.087	-0.246	-0.444	-0.144
	miR-21			0.9622,b	0.579b	-0.389	-0.273	-0.035	0.227	0.099	-0.173	0.501a	-0.040	-0.376
	miR-26b				0.7091,b	-0.071	-0.14	-0.072	0.023	-0.157	-0.290	0.366	-0.099	-0.245
	miR-155					0.177	0.141	-0.007	-0.209	-0.318	-0.004	0.098	-0.347	0.002
Gene expression of hepatic lipophagy	p62/Sqstm1						0.7761,b	0.313	-0.165	-0.283	-0.250	-0.334	0.065	0.8061,b
	Rubicon							0.488a	0.357	0.043	-0.107	-0.194	0.104	0.9092,b
	Cd36								0.6241,b	0.488a	0.553a	0.289	0.460a	0.339
	Tfeb									0.7881,b	0.266	0.6791,b	0.428	0.275
	Plin2										0.466	0.6551,b	0.199	-0.024
	Plin3											0.378	0.138	-0.142
	Plin5												0.256	-0.066
	Lamp2													0.192

¹Variables represent Pearson's correlation coefficient, strong (0.6 < r < 0.9).

²Variables represent Pearson's correlation coefficient, very strong (0.9 < r < 1.0).

^aP < 0.005, correlation is significant.

^bP < 0.001, correlation is significant.

Variables was represented for Pearson's correlation coefficient, moderate (0.3 < r < 0.6), strong (0.6 < r < 0.9) or very strong (0.9 < r <1.0). Lamp2: Lysosome-associated membrane proteins-2; mi: Micro; Plin: Perilipin; p62/Sqstm1: P62/sequestosome-1; Sirt1: Sirtuin; Tfeb: Transcription factor EB.