Primary hepatic leiomyosarcoma: A case report and literature review

Table 1 Management outcomes of published case reports of primary hepatic leiomyosarcoma

Ref.	Patient age in yr	Sex	Risk factor/s	Management	Follow-up/ outcome
Jeong et al[12], 2008	49	F		Wedge resection	Died at 18 mo
Cioffi et al[2], 1996	62	M			Died at 20 mo
O'Leary et al[27], 1982	69	M			Alive at 24 mo
Baur et al[28], 1993	69	F		Surgery	Recurrence after 10 yr
Sato et al[29], 2000	62	F			Diagnosis at autopsy
Iordanidis et al[30] , 2002	25	M		Surgery	Death at three mo
Lee et al[31], 2002	64	F		Right lobectomy + wedge resection of the left lobe	No evidence of disease at 24 mo
Shivathirthan et al[32], 2011	78	M		Chemotherapy, radiation	Death at 10 mo
Muranushi et al[33], 2019	62	M	Gastric gist post resection	Left hepatectomy+ resection of 3 other lesions	No evidence of disease
Watanabe et al[34], 1991	62	M		Lobectomy	No evidence of disease at 5 mo
Esposito et al[35], 2020	78	M		Left hepatectomy	No evidence of disease at 18 mo
Yoshikawa et al[36], 1977	58	F		Wedge resection	Death, 11th postoperative day
Bloustein[37], 1978	12	F		Trisegmentectomy, chemotherapy	No evidence of disease at 6 yr
Maki et al[6], 1987	86	F		Surgery	No evidence of disease at 5 mo
Holloway et al[15], 1996	63	M		Conservative
Soyer et al[19], 1996	67	F		Surgery
Tsuji et al[10], 2000	68	M	Hepatitis c		Diagnosis at autopsy
Fujita et al[9], 2002	33	F	Prior renal transplant	Right posterior segmentectomy	No evidence of disease at 24 mo
Giuliante et al[11], 2009	26	M	Hodgkin's lymphoma	Right lobectomy + wedge resection of segment id	Death at 25 mo
Liang et al[21], 2009	44	F		Liver transplant	Death at 34 mo
Shivathirthan et al[32], 2011	67	M		Extended left hepatectomy + partial resection of segment 6	No evidence of disease at 9 mo
Tsai et al[5], 2013	Five mo	M		Chemotherapy + partial hepatectomy (segment vi) + adjuvant chemotherapy	No evidence of disease at 48 mo
Feretis et al[24], 2019	68	F	Hepatitis b	Left hepatectomy+ cholecystectomy, chemotherapy, target therapy, redo surgery for recurrence	Recurrence at 18 mo 2nd recurrence at 21 mo died at 37 mo
Zhu et al[25], 2019	63	M		Unresectable tumor TACE (2011)	No evidence of disease at 82 mo
Vella et al[1], 2020	77	F		Right hepatectomy	No evidence of disease at 8 mo

F: Female; M: Male; TACE: Transcatheter arterial chemoembolization.

Table 2 Management outcomes of published case series of primary hepatic leiomyosarcoma

Ref.	Patient age in yr	Sex	Treatment	Follow up
Almogy et al[22], 2004	58	F	Surgery + chemotherapy	Death at 4 mo
	63	F	Surgery + chemotherapy	Death at 12 mo
Watanabe et al[34], 2008	63	F		Diagnosis at autopsy
	49	F		Diagnosis at autopsy
Matthaei et al[14], 2009	19	F	Liver transplant	Death at 73 mo
	64	F	Surgery	No evidence of disease 181 mo
	53	F	Surgery	Death at 21 mo
	55	M	Surgery	No evidence of disease at 133 mo
	51	M	Liver transplant	No evidence of disease at 144 mo
	59	M	Surgery	Death at 45 mo
	63	F	Surgery	No evidence of disease at 133 mo
Shamseddine et al[23], 2010	25	F	Right lobectomy	Death at 22 mo
	39	M	Extended right lobectomy	Death at 19 d
	30	M	Right lobectomy + chemotherapy	No evidence of disease at 12 mo
Esposito et al[35] ,2020	78	M	Left hepatectomy	No evidence of disease at 18 mo
	53	M	Right extended hepatectomy	Lung metastasis at seven mo death at 14 mo

F: Female; M: Male.