Iohexol plasma and urinary concentrations in cirrhotic patients: A pilot study

Table 1 Patient’s main characteristics median (min-max)

Characteristics	Median (min-max)
Age (yr)	60 (47-70)
Sex ratio (M:F)	1
Etiology of cirrhosis	Alcohol 78% - mixed1 22%
MELD	17 (8-33)
Child Pugh	7 (5-12)
Serum creatinine (µmol/L)	87 (53-142)
CKD-EPI (mL/min/1.73 m²)	83 (46-120)
MDRD 4 (mL/min/1.73 m²)	78 (44-144)
MDRD 6 (mL/min/1.73 m²)	86 (46-134)
RFH (mL/min/1.73 m²)	55 (32-105)
BM formula (mL/min/1.73 m²)	70 (40-139)
mCl plas (mL/min)	64 (41-111)
mCl urin (mL/min)	59 (42-100)
Serum albumin (g/L)	34.2 (26-37.7)
SBP (mmHg)	120 (101-140)
DBP (mmHg)	70 (60-89)
Weight (kg)	96 (70-143)
BMI (kg/m²)	32.8 (22.3-48.3)
Natremia (mmol/L)	132 (118-139)
Diuretics	56%
Bilirubin (µmol/L)	29.9 (10.2-159)
ALKP (UI/L)	136 (73-323)

¹Mixed = alcoholic and non-alcoholic steatohepatitis. RHF: Royal Free Hospital Formula; BM: Brochner-Mortensen formula, mCl plas: Measured plasmatic clearance; mCl urin: Extrapolated urinary clearance; SBP: Systolic Blood Pressure; DBP: Diastolic blood pressure; BMI: Body mass index; ALKP: Alkaline phosphatase.

Table 2 Non compartmental analysis: iohexol pharmacokinetic parameters

Patient no.	Cl plas (mL/min)	Cl urin (mL/min)	K plas (min-1)	Cmax (mg/L)	Vd (mL)	AUC 0-inf (mg/h/L)	AUC 0-24 h (mg/h/L)	%
1	63.71	52.89	0.003211	284	19839.7	846.26	830.171	-1.9
2	55.92	46.33	0.002345	196	23852.5	964.113	924.802	-4.1
3	58.70	48.17	0.002031	148	28897.5	918.45	860.117	-6.4
4	76.25	79.24	0.002644	154	28830.0	707.119	686.323	-2.9
5	111.26	93.53	0.003635	227	30607.4	484.599	480.014	-0.9
6	79.01	74.79	0.004057	202	19475.6	682.396	680.013	-0.3
7	41.27	42.26	0.001994	173	20689.5	1306.38	1226.09	-6.1
8	79.88	99.89	0.003817	247	20924.1	674.929	671.568	-0.5
9	63.39	58.17	0.001947	140	32556.8	850.604	779.724	-8.3

Cl plas: Measured plasma clearance of iohexol; Cl urin: Extrapolated urinary clearance of Iohexol; k plas: Plasmatic elimination constant; C max: Plasma maximal concentration; Vd: Distribution volume; AUC: Area under the curve.