Efficacy and safety of sofosbuvir/velpatasvir with or without ribavirin in hepatitis C genotype 3 compensated cirrhosis: A meta-analysis

doi:10.4254/wjh.v14.i6.1248

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World Journal of Hepatology

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Meta-Analysis

World J Hepatol. Jun 27, 2022; 14(6): 1248-1257
Published online Jun 27, 2022. doi: 10.4254/wjh.v14.i6.1248

Table 1 Baseline characteristics of included studies

Ref.	Study design	Sample size (n)	Age	Subtypes (3A/3B), (%)	Co-infection with HIV (%)	Baseline NS5A RAS (%)	Prior treatment (%)	SVR12 ITT (%)	SVR12 PP (%)	Treatment-related adverse event (%)
Pianko et al[22], 2015	RCT	52	I: 54.0 (44-65); C: 56 (45-68)	NR	0	NR	I: 100.0; C: 100.0	I: 96.2; C: 88.5	I: 96.2; C: 88.5	NR
Esteban et al[16], 2018	RCT	204	I: 51 ± 7.6; C: 51 ± 7.3	I: 100.0/0.0; C: 99.0/1.0	I: 15.5; C: 13.9	I: 21.8; C: 19.4	I: 27.2; C: 26.7	I: 96.1; C: 91.1	I: 96.1; C: 92.0	I: 4.9; C: 1.0
von Felden et al[23], 2018	Cohort study	65	NR	NR	I: 2.9; C: 13.3	I: 11.4; C: 0.0	I: 37.1; C: 23.3	I: 100.0; C: 96.7	NR	NR
Drysdale et al[26], 2019	Cohort study	414	NR	NR	NR	NR	NR	NR	I: 98.0; C: 91.7	NR
Pasulo et al[27], 2019	Cohort study	130	NR	NR	NR	NR	NR	NR	I: 93.9; C: 98.4	NR
Hlaing et al[24], 2019	Cohort study	60	NR	NR	NR	NR	NR	NR	I: 100.0; C: 96.0	I: 31.4; C: 8.0
Wong et al[30], 2020	Cohort study	163	NR	NR	NR	NR	NR	I: 97.8; C: 97.5	I: 97.8; C: 97.5	NR

HIV: Human immunodeficiency virus; NS5A: Non-structural protein 5A; RAS: Resistance-associated substitution; SVR12: Sustained virological response 12 wk post treatment; ITT: Intention-to-treat; PP: Per-protocol; RCT: Randomized controlled trial; I: Intervention (sofosbuvir/velpatasvir + ribavirin), C: Control (sofosbuvir/velpatasvir), NR: Not reported.

Table 2 Subgroup analysis

Outcome	Subgroup		No. of studies	Effect size (RR with 95%CI)	I²
SVR12 (ITT analysis)	Overall		4	1.03 (0.99-1.07)	0
	Study design	RCT	2	1.06 (0.99-1.13)	0
	Study design	Non-RCT	2	1.01 (0.97-1.06)	0
	Effect estimates	Fixed model	4	1.04 (1.00-1.08)	0
	Effect estimates	Odd’s ratio	4	2.32 (0.91-5.89)	0
SVR12 (PP analysis)	Overall		6	1.03 (0.99-1.07)	48
	Study design	RCT	2	1.06 (1.00-1.13)	0
	Study design	Non-RCT	4	1.02 (0.97-1.07)	65
	Publication type	Full-text	4	1.00 (0.96-1.04)	0
	Publication type	Abstract	2	0.99 (0.88-1.10)	86
	Effect estimates	Fixed model	6	1.04 (1.01-1.07)	48
	Effect estimates	Odd’s ratio	6	2.36 (1.07-5.19)	14

SVR12: Sustained virological response 12 wk post treatment; ITT: Intention-to-treat; PP: Per-protocol; RCT: Randomized controlled trial.

Citation: Loo JH, Xu WXF, Low JT, Tay WX, Ang LS, Tam YC, Thurairajah PH, Kumar R, Wong YJ. Efficacy and safety of sofosbuvir/velpatasvir with or without ribavirin in hepatitis C genotype 3 compensated cirrhosis: A meta-analysis. World J Hepatol 2022; 14(6): 1248-1257
URL: https://www.wjgnet.com/1948-5182/full/v14/i6/1248.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i6.1248