DNA and RNA oxidative damage in hepatocellular carcinoma patients and mortality during the first year of liver transplantation

Table 1 Clinical and biochemical characteristics of 1-year liver transplantation survivor and non-survivor patients

	1 yr survivor patients, n = 101	1 yr non-survivor patients, n = 13	P value
Serum OGS (ng/mL)–median (p 25-75)	2.80 (2.20-4.00)	4.00 (2.70-10.25)	0.01
Age of liver recipient (yr)-median (p 25-75)	58 (52-62)	57 (55-63)	0.61
Serum alpha-fetoprotein (ng/dL)-median (p 25-75)	7.4 (4.0-21.6)	8.4 (4.3-130.5)	0.62
Protein (g/dL)-median (p 25-75)	6.70 (6.10-7.10)	6.70 (5.58-7.63)	0.90
Leukocytes count–median × 103/mm3 (p 25-75)	4.57 (3.48-6.01)	4.52 (3.27-7.77)	0.89
Albumin (g/dL)-median (p 25-75)	3.29 (2.89-3.99)	3.47 (3.14-3.93)	0.45
Creatinine (mg/dL)-median (p 25-75)	0.90 (0.78-1.10)	1.02 (0.75-1.10)	0.27
BMI (kg/m2)-median (p 25-75)	27.3 (24.3-29.7)	28.7 (24.9-31.8)	0.26
Nodules size (cm)-median (p 25-75)	2.9 (2.0-3.4)	3.2 (1.8-4.9)	0.40
MELD score-median (p 25-75)	15 (11-18)	15 (13-17)	0.77
Age of liver donor (yr)-median (p 25-75)	51 (35-62)	62 (49-72)	0.03
Gender female, n (%)	19 (18.8)	0	0.12
Child-Pugh score, n (%)			0.06
A	46 (45.5)	10 (76.9)
B	29 (28.7)	3 (23.1)
C	26 (25.7)	0
Infiltration, n (%)	32 (31.7)	3 (23.1)	0.75
Macrovascular invasion, n (%)	4 (4.0)	0	0.99
Microvascular invasion, n (%)	19 (18.8)	2 (15.4)	0.99
Multinodular tumor, n (%)	27 (26.7)	4 (30.8)	0.75
Portal hypertension, n (%)	64 (63.4)	9 (69.2)	0.77
Treatment previously to LT, n (%)	56 (55.4)	8 (61.5)	0.77
PEI, n (%)	26 (25.7)	5 (38.5)	0.33
RFA, n (%)	6 (5.9)	0	0.99
TACE, n (%)	18 (17.8)	3 (23.1)	0.71
Liver resection, n (%)	3 (3.0)	0	0.99
Mixed treatment, n (%)	3 (3.0)	0	0.99
Transplantation technique, n (%)			0.99
By-pass	44 (43.6)	6 (46.2)
Piggy back	57 (56.4)	7 (53.8)
Degree of tumor differentiation, n (%)			0.11
Well	76 (75.2)	11 (84.6)
Moderate	24 (23.8)	1 (7.7)
Poor	1 (1.0)	1 (7.7)
Inside Milan criteria previously to LT, n (%)	96 (95.0)	12 (92.3)	0.53
Inside Milan criteria after LT, n (%)	85 (84.2)	10 (76.9)	0.45

OGS: Oxidized guanine species; MELD: Model for end-stage liver disease; PEI: Percutaneous ethanol injection; RFA: Radiofrequency ablation; LT: Liver transplantation; TACE: Transarterial chemoembolization; BMI: Body mass index.

Table 2 Logistic regression analysis for the variables associated with 1-year liver transplantation mortality

	Odds ratio	95%CI	P value
Age of liver donor (age)	1.087	1.019-1.160	0.01
Serum oxidized guanine species levels (ng/mL)	2.079	1.356-3.189	0.001
Serum caspase-3 levels (ng/mL)	4.178	1.709-10.211	0.002

CI: Confidence interval.