Prevalence of hypothyroidism and effect of thyroid hormone replacement therapy in patients with non-alcoholic fatty liver disease: A population-based study

Table 1 Baseline characteristics of patients with hypothyroidism in explorys database

Parameter		Hypothyroidism
		Present (%)	Absent (%)
Age (yr)	18-65	1335370 (48.3)	21097850 (60.5)
	> 65	1402550 (50.7)	6951210 (19.9)
Gender	Female	2087040 (75.5)	18562590 (53.2)
Race	Caucasian	2267940 (82.0)	20165960 (57.8)
	African-American	196720 (7.1)	4120940 (11.8)
	Asian	40710 (1.5)	539190 (1.5)
Comorbidities	HTN	1665090 (60.2)	7441760 (21.3)
	T2DM	790680 (28.6)	3114700 (8.9)
	Dyslipidemia	1716240 (62.1)	6469880 (18.5)
	Obesity	753060 (27.2)	3391060 (9.7)
	Metabolic syndrome	54440 (2.0)	2709750 (7.8)

HTN: Hypertension; T2DM: Type 2 diabetes mellites.

Table 2 Multivariate analysis for risk factors in individuals with non-alcoholic fatty liver disease

Parameter	Odds ratio	95%CI	P value
Age (18-65)	1.658	1.524-1.804	< 0.0001
Male	1.008	0.934-1.088	0.841
Caucasian	1.636	1.489-1.799	< 0.0001
Obesity	3.616	3.318-3.940	< 0.0001
T2DM	2.178	1.994-2.379	< 0.0001
Dyslipidemia	2.346	2.121-2.596	< 0.0001
Hypertension	1.326	1.201-1.465	< 0.0001
Metabolic syndrome	4.782	4.782-5.460	< 0.0001
Hypothyroidism	1.587	1.388-1.815	< 0.0001
Hypothyroidism on Thyroxine replacement therapy	1.106	0.952-1.285	0.188

T2DM: Type 2 diabetes mellites.