Renal manifestations of hepatitis E among immunocompetent and solid organ transplant recipients

Table 1 Renal manifestations of the reported cases of hepatitis E virus infection among immunocompetent and solid organ recipients

Case study	Status	Age	Sex	Country	Serum creatinine/eGFR	Renal manifestations	Treatment	Follow up	Outcomes
Karki et al[30]	I.C	48 yr	M	India	8.1 mg/dL	ATN(Hemoglobin Cast)	Hemodialysis; Supportive care	3 mo	Improved kidney function
Verschuuren et al[13]	I.C	34 yr	F	Netherlands	10 mg/dL	ATN	Hemodialysis; Supportive care	3 wk	Complete kidney function recovery
Biliotti et al[51]	I.C	57 yr	M	Italy	44 mL/min	NR	Sofosbuvir; Ribavarin	3 wk	Patient died from MRSA infection
Guinault et al[33]	I.C	48 yr	M	France	3.6 mg/dL	MPGN	Steroids	4 mo
Kamar et al[34]	K.T	33 yr	M	France	2.1 mg/dL	MPGN	Steroids	16 mo	Improved kidney function
Kamar et al[34]	K.T	26 yr	M	France	2.4 mg/dL	IgAN	Ribavarin 3 mo	9 mo	Stable kidney function
Kamar et al[34]	K.T	40 yr	M	France	2.1 mg/dL	IgAN	Change in IS + Rituximab	3 mo
Kamar et al[34]	K.T	24 yr	M	France	2.3 mg/dL	MPGN	Rituximab	3 yr	Renal replacement therapy
Kamar et al[52]	K.T	28 yr	M	France	2.4 mg/dL	ATN	None	3 mo	Serum creatinine returned to baseline
Del Bello et al[32]	K.T	46 yr	M	France	2 mg/dL	MPGN	Ribavarin 30 mo	12 mo	Improved serum creatinine

NR: Not reported; eGFR: Estimated glomerular filtration rate; I.C: Immunocompromised; K.T: Kidney transplant; M: Male; F: Female; ATN: Acute tubular necrosis; MPGN: Membranoproliferative glomerulonephritis; IgAN: IgA nephropathy.