Two-stage hepatectomy with radioembolization for bilateral colorectal liver metastases: A case report

Table 1 Review of the literature including patients submitted to preoperative trans-arterial radioembolization for colorectal liver metastases

Ref.	Year	Type of study	Pts included, n	CRLM1, n (%)	Tumor location (n)	Bilobar n (%)	Prior resection, n (%)	Resectability, n (%)
Gray et al[18]	2001	HAI vs HAI + TARE in unresectable CRLM; RCT	74	36 (48.6)	Colon (29), rectum (7)	36/36 (100)	0	1/36 (2.8)
Lim et al[6]	2005	TARE after failure of FU in unresectable CRLM; prospective	30	30 (100)	NA	NA	0	1/30 (3.3)
Sharma et al[7]	2007	TARE + FOLFOX4 in unresectable CRLM; prospective (phase I)	20	20 (100)	Right colon (4), sigmoid (5), rectum (4), other colon sites (7)	NA	0	2/20 (10)
Cosimelli et al[19]	2010	TARE in unresectable CRLM; prospective (phase II)	50	50 (100)	Colon (41), rectum (9)	35/50 (70)	12/50 (24.0)	2/50 (4.0)
Hendlisz et al[8]	2010	FU vs TARE + FU in unresectable CRLM; RCT	44	21 (47.7)	NA	NA	NA	1/21 (4.8)
Brown et al[9]	2011	TARE vs CHT vs no therapy before hepatectomy; case-control	840	16 (1.9)	NA	NA	NA	16/16 (100)
Whitney et al[10]	2011	TARE in unresectable liver disease; retrospective	44	15 (34)	Rectum (15)	0	0	1/15 (6.7)
Vouche et al[11]	2013	TARE in unresectable liver disease; retrospective	83	8 (9.6)	NA	0	0	1 (12.5)
Wang et al[20]	2013	TARE before liver resection for CRLM; retrospective	24	24 (100)	Sigmoid (1), rectum (1), other colon sites (1), unknown (21)	1/3 (33.3)	0	3/24 (12.5)
Henry et al[12]	2015	TARE before liver resection for metastatic cancer; retrospective	9	4 (44.4)	NA	NA	0	4/4 (100)
Justinger et al[22]	2015	TARE in marginally resectable CRLM; retrospective	13	13 (100)	Right colon (2), sigmoid (4), rectum (7)	9/13 (69.2)	7/13 (53.8)2	11/13 (84.6)
Moir et al[13]	2015	TARE in unresectable liver disease; retrospective	44	22 (50)	NA	NA	NA	4/22 (18.2)
Maleux et al[14]	2016	TARE in unresectable CRLM; NA	88	71 (80.6)	NA	58/71 (81.6)	10/71 (14.0)	1/71 (1.4)
Lewandowski et al[23]	2016	TARE in unresectable right-sided liver disease; retrospective	13	1 (7.6)	NA	0	NA	1/1 (100)
Wright et al[15]	2017	TARE in unresectable liver disease; retrospective	465	6 (1.2)	NA	NA	NA	6/6 (100)
van Hazel et al[16]	2016	FOLFOX6 vs FOLFOX6 + TARE ± Bevacizumab; RCT	530	267 (50.3)	Left colon (141), right colon (72), rectum (45), other colon sites (7), unknown (2)	NA	NA	38/267 (14.2)
Pardo et al[21]	2017	TARE before liver resection or transplantation; retrospective	100	30 (30)	NA	44/100	7/30 (23.3)2	30/30 (100)
Wasan et al[17]	2017	FOLFOX vs FOLFOX + TARE; RCT	1103	554 (50.2)	Colon (421), rectum (116), unknown (17)	NA	NA	56/554 (10.1)

¹Treated with transarterial radioembolization.

²Associating liver partition and portal vein ligation for staged hepatectomy. CHT: Chemotherapy; CRLM: Colorectal liver metastases; FU: Florouracil; HAI: Hepatic artery infusion; NA: Not available; RCT: Randomized controlled trial; TARE: Transarterial radioembolization.

Table 2 Review of the literature including patients submitted to preoperative trans-arterial radioembolization for colorectal liver metastases

Ref.	FLR increase %	Time TARE-surgery, median (range), mo	Type of hepatic resection (n)	Post-operative mortality %	Survival, median (range), mo	Disease free, median (range), mo	Recurrence after surgery, n (%)
Gray et al[18]	NA	NA	NA	0	96	NA	NA
Lim et al[6]	NA	NA	NA	NA	NA	22	1/1 (100)
Sharma et al[7]	NA	NA	LLS + S6 (1), RH + S3 (1)	NA	NA	NA	NA
Hendlisz et al[8]	NA	NA	RH (1)	0	NA	1.5	1/1 (100)
Brown et al[9]	NA	6.5 (4-13)	NA	NA	NA	NA	NA
Whitney et al[10]	NA	NA	RT (1)	0	NA	24	1/1 (100)
Vouche et al[11]	NA	NA	RT (1)	0	NA	NA	NA
Wang et al[20]	NA	NA (4-9)	RH (2), LH + S6 (1)	0	NA	NA	NA
Henry et al[12]	NA	5 (2-8)	LLS (1), multiple wedge, HAI pump (1), RT + RFA (1), RT (1)	50	13 (0-27)	6.2 (1.8-10.5)	3/4 (75)
Justinger et al[22]	32.9 (ALPPS), 27.1 (no ALPPS)	2 (1-5)	RT (4), RH (5), mesohepatectomy (1), LT (1)	7.6	25 (12-38)1	NA	NA
Moir et al[13]	NA	4 (2-11)	NA	0	15 (11-19)1	NA	NA
Maleux et al[14]	NA	NA	S + RFA (1)	0	NA	NA	NA
Lewandowski et al[23]	15	1.6 (1-7)	RT (1)	0	4.8	NA	NA
Wright et al[15]	NA	9 (3-20)	RT (2), S (1), RH (3)	16.6	25 (NA)	NA	NA
van Hazel et al[16]	NA	NA	NA	0	NA	NA	NA
Pardo et al[21]	NA	NA	NA	10	NA	NA	NA
Wasan et al[17]	NA	NA	NA	3.6	NA	NA	NA

¹95% confidence interval. ALPPS: Associating liver partition and portal vein ligation for staged hepatectomy; HAI: Hepatic artery infusion; LH: Left hepatectomy; LLS: Left lateral sectionectomy; LT: Left trisectionectomy; RFA: Radiofrequency ablation; RH: Right hepatectomy; RT: Right trisectionectomy; S: Segmentectomy; NA: Not available.