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Copyright ©The Author(s) 2021.
World J Hepatol. Dec 27, 2021; 13(12): 1919-1935
Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.1919
Table 1 Comparison of characteristics of invasive and non-invasive methods
No.
Feature
Invasive
Non-invasive
1InvasivenessYesNo
2Sampling errorYesNo
3Cost-effectiveNoYes
4Patient-friendlyNoYes
5Hospitalization requiredYesNo
Table 2 Scoring systems for liver fibrosis
Stage
IASL
Batts-Ludwig
METAVIR
No fibrosisNo fibrosisStage 0F0
Fibrosis portal expansionMild fibrosisStage 1F1
Few bridges or septaModerate fibrosisStage 2F2
Numerous bridges or septaSevere fibrosisStage 3F3
CirrhosisCirrhosisStage 4F4
Table 3 Correlation of transient elastography cutoffs with METAVIRscore
METAVIR score
Cutoff TE score (kPa)
Sensitivity
Specificity
NPV
PPV
F ≥ 2 (F0-F1 vs F2-4)7.10.670.890.480.95
F ≥ 3 (F0-F1-F2 vs F3, 4)9.50.730.910.810.87
F ≥ 4 (F0-F1-F2-F3 vs F4)12.50.870.910.950.77
Table 4 Sensitivity and specificity of non-invasive biomarkers in liver fibrosis
Marker
Parameters involved
Disease
AUROC for liver fibrosis
Sensitivity
Specificity
Ref.
AST/ALT ratioAST and ALTNAFLD; HCV0.83; -74; 4778; 96McPherson et al[87]; Park et al[88]
BARD scoreBMI, AST, ALT, DMNAFLD0.767466Sun et al[89]
APRIAST, platelet countNAFLD0.672789McPherson et al[87]
ALTALTHCV0.716-0.815--Pradat et al[59]
Forns indexAge, platelet count, GGT, cholesterolHCV0.81-0.869451Forns et al[60]
PGA and PGAAProthrombin time, GGT, apolipoprotein A1, α2 macroglobulinAcute liver disease0.84-0.86--Nguyen-Khac et al[90]
FIB-4Platelet count, AST, ALT, ageHCV; NAFLD0.74-0.77; 0.8567; 8471; 69Sebastiani[23]; Sun et al[89]
Fibro testHaptoglobin, apolipoprotein A1, α2 macroglobulin, GGT, bilirubin, age, and genderHBV; HCV; ALD0.84; 0.87; 0.8361; 75; -80; 85; -Salkic et al[91]; Imbert-Bismut et al[66]; Naveau et al[62]
HepascoreGGT, bilirubin, HA, α2 macroglobulin, age, and genderHCV0.82--Naveau et al[62], Adams et al[92]
SHASTA indexHA, AST, and albuminHCV0.875094Kelleher et al[93]
Fibrospect IIα2 macroglobulin, HA, and TIMP-1HCV0.82-0.8377-8366-73Patel et al[94]