Copyright
©The Author(s) 2019.
World J Hepatol. Apr 27, 2019; 11(4): 391-401
Published online Apr 27, 2019. doi: 10.4254/wjh.v11.i4.391
Published online Apr 27, 2019. doi: 10.4254/wjh.v11.i4.391
Table 1 Characteristics of 83 patients with hidradenitis suppurative, Nonalcoholic fatty liver and Nonalcoholic steatohepatitis and intercalsses charactersitics
HS only | NAFLD | P value | NASH | P value | NAFL | P value | |
n | 51 | 32 | 12 | 20 | |||
Age, mean(SD) | 43.04 (8.9) | 41.32 (9.0) | 0.564 | 41.58 (7.4) | 0.602 | 40.55 (10.3) | 0.315 |
Age cat (%) | 0.646 | 0.463 | 0.629 | ||||
< 30 | 3 (5.9) | 4 (12.5) | 1 (8.3) | 3 (15.0) | |||
30-39 | 16 (31.4) | 8 (25.0) | 2 (16.7) | 6 (30) | |||
40-49 | 18 (35.3) | 14 (43.8) | 7 (58.3) | 7 (35.0) | |||
> 50 | 14 (27.5) | 6 (18.8) | 2 (16.7) | 4 (20.0) | |||
Male, n (%) | 17 (33.3) | 14 (43.8) | 0.623 | 5 (41.7) | 0.835 | 9 (45.0) | 0.52 |
Diabetes, n (%) | 12 (23.5) | 9 (28.1) | 0.853 | 3 (25.0) | 0.764 | 6 (30.0) | 0.794 |
BMI, mean(SD) | 28.31 (2.5) | 27.56 (1.9) | 0.381 | 27.58 (2.7) | 0.376 | 27.55 (1.7) | 0.218 |
bmi_cat (%) | 0.559 | 0.515 | 0.384 | ||||
Normal Weight | 4 (7.8) | 4 (12.5) | 2 (16.7) | 2 (10.0) | |||
Overweight | 38 (74.5) | 26 (81.3) | 9 (75.0) | 17 (85.0) | |||
Obese | 9 (17.6) | 2 (6.3) | 1 (8.3) | 1 (5.0) | |||
IHS4, mean(SD) | 9.57 (3.6) | 11.32 (2.8) | 0.025 | 12.67 (3.6) | 0.009 | 9.40 (3.9). | 0.861 |
IHS4 cat (%) | 0.028 | 0.007 | 0.97 | ||||
Mild | 5 (9.8) | 3 (9.4) | 1 (8.3) | 2 (10.0) | |||
Moderate | 24 (47.1) | 10 (31.3) | 0 (0) | 10 (50.0) | |||
Severe | 22 (43.1) | 19 (59.4) | 11 (91.7) | 8 (40) | |||
Hurley (%) | 0.494 | 0.197 | 0.785 | ||||
1 | 5 (9.8) | 3 (9.4) | 1 (8.3) | 2 (10.0) | |||
2 | 24 (47.1) | 6 (18.8) | 1 (8.3) | 5 (25.0) | |||
3 | 22 (43.1) | 23 (71.9) | 10 (83.3) | 13 (65.0) | |||
Elevated_liver_enzymes, n (%) | 19 (37.3) | 9 (28.1) | 0.617 | 4 (33.3) | 0.998 | 5 (25.0) | 0.482 |
ADDI_score, mean(SD) | 2.55 (1.4) | 3.72 (1.8) | < 0.001 | 5.33 (2.2) | < 0.001 | 2.75 (1.6) | 0.603 |
Inflammatory comorbidities, n (%) | 2 (3.9) | 12 (37.5) | < 0.001 | 7 (58.3) | < 0.001 | 5 (25.0) | 0.025 |
In detail (%) | 0.001 | < 0.001 | 0.047 | ||||
Acne conglobata | 1 (2.0) | 0 (0) | 0 (0) | 0 (0) | |||
Crohn disease | 0 (0) | 2 (6.3) | 1 (8.3) | 1 (5.0) | |||
Lichen sclerosus | 1 (2.0) | 0 (0) | 0 (0) | 0 (0) | |||
PASH | 0 (0) | 5 (15.6) | 4 (33.3) | 1 (5.0) | |||
Psoriasis | 0 (0) | 2 (6.3) | 1 (8.3) | 1 (5.0) | |||
Spondyloarthritis | 0 (0) | 2 (6.3) | 1 (8.3) | 1 (5.0) | |||
Uveitis | 0 (0) | 1 (3.1) | 0 (0) | 1 (5.0) | |||
Positive ultrasound, n (%) | 11 (21.6) | 32 (100.0) | < 0.001 | 12 (100.0) | < 0.001 | 20 (100.0) | < 0.001 |
NASH | 0 (0) | 12 (37.5) | < 0.001 | 12 (100.0) | 0 (0) | ||
NAFL | 0 (0) | 20 (62.5) | < 0.001 | 0 (0) | 20 (100.0) |
Table 2 Differences among hidradenitis suppurativa patients with and without diabetes
Non diabetes | Diabetes | P value | |
n | 62 | 21 | |
Age, mean(SD) | 42.44 (9.4) | 41.62 (8.2) | 0.722 |
Age cat (%) | 0.203 | ||
< 30 | 4 ( 6.5) | 3 (14.3) | |
> 50 | 17 (27.4) | 3 (14.3) | |
30-39 | 20 (32.3) | 4 (19.0) | |
40-49 | 21 (33.9) | 11 (52.4) | |
Male, n (%) | 21 (33.9) | 10 ( 47.6) | 0.387 |
Diabetes, n (%) | 0 ( 0.0) | 21 (100.0) | <0.001 |
BMI, mean(SD) | 28.10 (2.6) | 27.81 (1.4) | 0.636 |
bmi_cat (%) | 0.161 | ||
Normal Weight | 8 (12.9) | 0 ( 0.0) | |
Obese | 9 (14.5) | 2 ( 9.5) | |
Overweight | 45 (72.6) | 19 ( 90.5) | |
IHS4, mean(SD) | 10.37 (3.6) | 8.81 (4.1) | 0.101 |
IHS4 cat, n (%) | 0.051 | ||
Mild | 4 ( 6.5) | 4 ( 19.0) | |
Moderate | 23 (37.1) | 11 ( 52.4) | |
Severe | 35 (56.5) | 6 ( 28.6) | |
Hurley, n (%) | 0.022 | ||
1 | 4 ( 6.5) | 4 ( 19.0) | |
2 | 14 (22.6) | 9 ( 42.9) | |
3 | 44 (71.0) | 8 ( 38.1) | |
Elevated_liver_enzymes, n (%) | 21 (33.9) | 7 ( 33.3) | 1 |
ADDI_score, mean(SD) | 3.13 (1.8) | 2.62 (2.0) | 0.275 |
Inflammatory comorbidities, n (%) | 9 (14.5) | 5 ( 23.8) | 0.518 |
In.detail, n (%) | 0.563 | ||
53 (85.5) | 16 ( 76.2) | ||
Acne conglobata | 1 ( 1.6) | 0 ( 0.0) | |
Crohn | 1 ( 1.6) | 1 ( 4.8) | |
Lichen sclerosus | 0 ( 0.0) | 1 ( 4.8) | |
PASH | 4 ( 6.5) | 1 ( 4.8) | |
Psoriasis | 1 ( 1.6) | 1 ( 4.8) | |
Spondyloarthritis | 1 ( 1.6) | 1 ( 4.8) | |
Uveitis | 1 ( 1.6) | 0 ( 0.0) | |
Positive_ultrasound, n (%) | 31 (50.0) | 12 ( 57.1) | 0.754 |
NASH, n (%) | 9 (14.5) | 3 ( 14.3) | 1 |
NAFL, n (%) | 14 (22.6) | 6 ( 28.6) | 0.795 |
Disease, n (%) | 0.853 | ||
HS only | 39 (62.9) | 12 ( 57.1) | |
NAFL | 14 (22.6) | 6 ( 28.6) | |
NASH | 9 (14.5) | 3 ( 14.3) |
- Citation: Damiani G, Leone S, Fajgenbaum K, Bragazzi NL, Pacifico A, Conic RR, Pigatto PD, Maiorana C, Poli P, Berti E, Pace MC, Malagoli P, Bettoli V, Fiore M. Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis. World J Hepatol 2019; 11(4): 391-401
- URL: https://www.wjgnet.com/1948-5182/full/v11/i4/391.htm
- DOI: https://dx.doi.org/10.4254/wjh.v11.i4.391