Bariatric surgery in patients with non-alcoholic fatty liver disease - from pathophysiology to clinical effects

Table 1 Recent studies (2010-) with histological assessment of liver biopsies at follow-up

Ref.	Design	Patients with follow-up	Surgical inter-vention	Steatosis	Inflammation	Fibrosis	Any cases of worsening	Mean/median follow-up in months
Weiner et al[76], 2010	Missing	116	RYGB, AGB, BPD-DS	Improved, 70% complete resolution	Improved, 86% complete resolution	Improved	No	19.4 (± 8.3)
Moretto et al[77], 2012	Retrospective	78	Gastric bypass	Improved	Improved ballooning, 55% complete resolution of NASH	Trend for improvement	Yes	Unknown
Vargas et al[78], 2012	Prospective	26	RYGB	Improved	Improved, 84% complete resolution of NASH	Improved	No	16 (± 3)
Tai et al[79], 2012	Prospective	21	RYGB	Improved, 95% complete resolution	Improved, 100% complete resolution of NASH	Improved	Yes	12
Caiazzo et al[74], 2014	Prospective	578 (1 yr), 413 (5 yr)	RYGB, AGB	Improved	Improved	Improved	NA	12 and 60
Lassailly et al[10], 2015	Prospective	82	Gastric bypass, AGB, SG, PBD-DS	Improved	Improved, 85% complete resolution of NASH	Improved	NA	12
Praveen et al[80], 2015	Prospective	30	RYGB, SG	Improved in 97%	Improved in 46%	Improved in 46%	No	6
Taitano et al[75], 2015	Missing	160	RYGB, AGB	Improved, complete resolution in 73%	Improved, 88% complete resolution of NASH	Improved, 53% complete resolution	Yes	31 (± 26)
Schneck et al[81], 2016	Missing	9	RYGB	Improved in all patients	Improved in all patients	Improved	Yes	55 (44-75)
Froylich et al[82], 2016	Retrospective	25	RYGB, SG	Improved	Improved	Trend for improvement	NA	18
Aldoheyan et al[83], 2017	Prospective	27	SG	Improved	Improved	Improved	NA	3
Manco et al[84], 2017	Prospective	20	SG (n = 20) vs IGWLD, NSWL	Improved	Improved, 100% complete resolution of NASH	Improved	NA	12
Garg et al[85], 2018	Prospective	32	RYGB, AGB, SG	Improved	Improved	Improved	NA	12

RYGB: Roux-en-Y gastric bypass; AGB: Adjustable gastric banding; BPD-DS: Biliopancreatic diversion with duodenal switch; SG: Sleeve gastrectomy; IGWLD: Intragastric weight loss device; NSWL: Nonsurgical weight loss; NA: Not assessed.