Complements are involved in alcoholic fatty liver disease, hepatitis and fibrosis

Table 1 Important publications on complement in alcoholic liver disease

Study	Complement component	Alcoholic liver disease	Species
Järveläinen et al[10]	C1, Crry, CD59	Alcohol-induced injury	Rat
Bykov et al[11]	C3	Liver steatosis	Mouse
Pritchard et al[8]	C3, C5, DAF	Fatty liver	Mouse
He et al[7]	C3	Liver steatosis	Mouse
Cohen et al[13]	C1q	Alcohol-induced injury	Mouse
Wlazlo et al[27]	C3	Liver steatosis	Human
Shen et al[6]	C3	Alcoholic hepatitis	Mouse
Maslowska et al[30]	Factor D	Alcoholic hepatitis	Mouse

Crry: Complement receptor 1-related protein y; DAF: Decay accelerating factor.

Table 2 Complement regulators

Type of regulators	Regulators	Functions
Complement regulatory protein	DAF/CD55, Crry, FH, FI	Inhibit C3, C5 convertase
	CD59, protein S, clusterin	Inhibit MAC
Complement inhibitor	C1-INH	Inhibit C1r, C1s
Targeted inhibitor	h5G1, 1-ScFv	Inhibit C5 activation
RNA aptamer	Specifically bind C1q, C5

DAF: Decay accelerating factor; Crry: Complement receptor 1-related protein y; FH: Factor H; FI: Factor I; MAC: Membrane attack complex.