Collagen proportionate area correlates to hepatic venous pressure gradient in non-abstinent cirrhotic patients with alcoholic liver disease

Table 1 Patients characteristics

Variable	Controls (n = 9)	Alcohol abstinents (n = 20)	Active alcohol drinkers (n = 41)	P value (abstinent vs active alcohol drinkers)
Age (yr)	38.2 (35-49)	59.5 (55-65)	56.9 (52-63)	0.40
Male sex	6 (67%)	16 (80%)	33 (80%)	1.0
Ascites	0	11 (61%)	23 (64%)	1.0
HE	0	3 (16%)	7 (21%)	1.0
Esophageal varices	0	15 (83%)	25 (69%)	0.30
HVPG (mmHg)	2 (2-3)	18 (16-19)	18 (14-20)	0.90
Liver stiffness (kPa)	3.8 (3-3.8)	Not available	38.6 (14.6-68.2)	-
Platelet count (G/L)	286 (170-340)	44.5 (20-55)	33.5 (20-53)	0.40
Child-Pugh score	-	9.5 (8-10)	9 (8-11)	0.94
MELD score	-	14 (12-19)	19 (11-22)	0.50

HVPG: Hepatic venous pressure gradient; MELD: Model for end-stage liver disease.

Table 2 Histological features on transjugular liver biopsy

Variable	Controls (n = 9)	Alcohol abstinents (n = 20)	Active alcohol drinkers (n = 41)	P value (abstinent vs active alcohol drinkers)
Cirrhosis	0 (9%)	20 (100%)	41 (100%)	1.0
Marked steatosis	0 (0%)	1 (5%)	21 (51%)	0.001
Marked ballooned hepatocytes	0 (0%)	5 (26%)	25 (64%)	0.01
Marked inflammation	0 (0%)	0 (0%)	1 (2%)	0.9
Fibrosis density (%)	0.7 (0.2-1.5)	3.8 (1.1-11.8)	8.2 (3.8-14.1)	0.17
Fibrosis category				0.48
0%-5%	9	11	15
5%-10%	0	3	9
10%-20%	0	3	12
> 20%	0	3	5

Table 3 Characteristics of patients with alcoholic liver disease according to fibrosis density

Variable	Fibrosis density ≤ 5% (n = 26)	Fibrosis density > 5% (n = 35)	P value
Active alcohol	15 (58%)	26 (74%)	0.27
Age (yr)	58 (55-64)	57 (52-63)	0.4
Male sex	24 (92%)	25 (71%)	0.06
Ascites	12 (55%)	22 (69%)	0.4
HE	7 (32%)	3 (10%)	0.07
Esophageal varices	15 (65%)	25 (81%)	0.2
HVPG (mmHg)	16 (11-18)	19 (17-20)	0.01
Liver stiffness (kPa)	19 (12-42)	57 (34-72)	0.5
Platelet count (G/L)	37 (20-52)	38 (20-55)	0.7
MELD score	14 (11-19)	18 (13-22)	0.2
Histology
Marked steatosis	11 (42%)	11 (31%)	0.4
Marked ballooned hepatocytes	9 (36%)	21 (64%)	0.06
Marked inflammation	0 (0%)	1 (3%)	0.9

HVPG: Hepatic venous pressure gradient; MELD: Model for end-stage liver disease.