Clinical features, histology, and histogenesis of combined hepatocellular-cholangiocarcinoma

Figure 3 Combined hepatocellular-cholangiocarcinoma with stem cell features, intermediate subtype. A: H and E, 4 × - tumor is present in trabecular/nested pattern on the right side with ill-formed gland like structures seen on the left side; B: H and E, 10 × - tumor cells with intermediate features between hepatocytes and cholangiocytes; C: CD10, 10 × - tumor showing canalicular staining pattern for CD10 (hepatocytic marker); D: CK19, 4 × - tumor cells strongly and diffusely expressing CK19 (chlolangiocytic marker). Focal tumor cells were positive for Hep-Par1 and CD56 (not shown). H and E: Hematoxylin and eosin.