Resection of a rapid-growing 40-cm giant liver hemangioma

Abstract

Hemangiomas are the most frequent benign tumors of the liver. Most hemangiomas are asymptomatic and therefore largely diagnosed only in routine screening tests. Usually they are small and require no specific treatment. In some situations they can reach great dimensions, causing some discomfort to the patient. Resection of liver hemangioma is indicated in cases of great dimension tumors causing symptoms such as pain, nausea or bloating caused by compression of adjacent organs. We report a case of a rare giant hemangioma with rapid growth in short time: a 50 year old female reported to our institution with a 40 cm giant liver hemangioma and then underwent a left hepatectomy.

Key Words: Liver benign neoplasms; Giant liver Hemangioma; Liver surgery

INTRODUCTION

Hemangiomas are the most frequent benign tumors of the liver with an incidence ranging from 5% to 20% and women accounting for the largest part. Most hemangiomas are asymptomatic and therefore largely diagnosed only in routine screening tests. Usually they are small and require no specific treatment[1-5].

In some situations they can reach great dimensions, causing some discomfort to the patient. There is no consensus in the literature regarding the minimum size a hemangioma is considered as giant but in our service we use the limit of 10 cm. Rare cases of rupture followed by massive bleeding and Kassabach-Merrit’s syndrome with serious complications have been reported.

Resection of liver hemangioma is indicated in cases of great dimension tumors causing symptoms such as pain, nausea or bloating by compression of adjacent organs[6-9]. Resection is also advisable in a controversial diagnosis where malignancy cannot be fully eliminated[4-7].

CASE REPORT

We report a case of a rare giant hemangioma with rapid growth in a short time: a 50-year old female being monitored for 7 years since a liver hemangioma was incidentally diagnosed.

At that time, the lesion already measured 20 cm in its largest axis (Figure 1A). In the last 4 mo, she presented with symptoms such as a dry cough and in the last 2 mo, abdominal pain. CT scan evidenced an increase of 10 cm in the lesion in the left lobe with compression of the diaphragm, reaching 30 cm in its largest axis (Figure 1B).

Figure 1 Computed tomography scan of a patients with a liver hemangioma. A: The first scan performed 7 years ago, showing an oversized hemangioma on the left hepatic lobe; B: During the symptoms worsening a second CT-Scan showed tumor growth. The lesion reached the central portions of the liver.

An arterial embolization procedure was attempted in order to restrict the hemangioma growing. It brought no benefits but worsened the symptoms.

The patient then underwent a left hepatectomy. We usually access the abdominal cavity through a Chevron incision to perform hepatectomies. After liver mobilization was done, a great deformity in the vascular anatomy of the portal and supra hepatic veins was identified, mainly due to the compression caused by the huge hemangioma (Figure 2A). The left hepatic vein was involved by the tumor and had to be ligated. For a safe parenchymal transection, blood inflow and outflow control to the liver was performed. Pringle maneuver and the infra and supra hepatic vena cava were laced but not clamped. The liver transection was performed with kellyclasy and silkclasy[10] and hemostasis was achieved with cauterization. Figure 2B shows the final aspect of the resection. The anatomopathological findings confirmed the diagnosis of a 40 cm hemangioma in its largest axis (Figure 2C). The patient is now asymptomatic at 6 mo post-operation.

Figure 2 Surgical treatment of the patient with a liver hemangioma. A: After the laparotomy, a giant hemangioma was identified, and this lesion led to a great anatomical deformity in the liver; B: After the resection, the remnant liver in the cleared abdominal cavity; C: The 40 cm-giant liver hemangioma was sent to anatomical and pathological analysis.

DISCUSSION

After a review of our patient database, we found that the number of diagnosed liver hemangiomas greater than 10 cm is very low. The few patients with giant hemangiomas do not present with any signs of tumor growing at follow up. Therefore, resection of liver hemangiomas is quite restricted in our service; the main argument against the resection is the need of submitting a patient with a benign disease to such a major surgery. Interestingly, this was the only report of a size changing hemangioma in our experience.

The literature shows that arterial embolization of the lesion to contain the tumor growth is not effective unless the hemangioma is a lesion with a clear arterial blood supply[11]. At first we assumed that this hemangioma could have an arterial supply that would justify such a rapid size enhancement. The arterial embolization was the initial therapeutic approach but unfortunately the procedure did not help and, due to necrosis, worsened the pain for the patient.

Discussions on resection of hemangiomas include procedures on the so-called giant tumors or in those that result in symptoms to the patient. Reports on surgery due to hemangioma growth are rare[6].

In this report, our attention is drawn to the speed of the hemangioma increase, leading to abdominal pain and cough due to diaphragm compression. In our service, we maintain clinical follow-up of hemangiomas in asymptomatic patients regardless the size. Nevertheless, due to the particular evolution of this case (rapid growth and the tumor necrosis as a consequence of the arterial embolization), we decided to carry out the resection despite the consequent complications involved in this kind of procedure.