Hatanaka T, Arai H, Kakizaki S. Balloon-occluded transcatheter arterial chemoembolization for hepatocellular carcinoma. World J Hepatol 2018; 10(7): 485-495 [PMID: 30079135 DOI: 10.4254/wjh.v10.i7.485]
Corresponding Author of This Article
Satoru Kakizaki, MD, PhD, Associate Professor, Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Showa-machi, 3-39-15, Maebashi, Gunma 371-8511, Japan. kakizaki@gunma-u.ac.jp
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Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Satoru Kakizaki, MD, PhD, Associate Professor, Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Showa-machi, 3-39-15, Maebashi, Gunma 371-8511, Japan. kakizaki@gunma-u.ac.jp
Telephone: +81-27-2208127 Fax: +81-27-2208136
Received: March 27, 2018 Peer-review started: March 27, 2018 First decision: April 11, 2018 Revised: June 24, 2018 Accepted: June 28, 2018 Article in press: June 28, 2018 Published online: July 27, 2018
Abstract
Transcatheter arterial chemoembolization (TACE) is widely accepted as a treatment for patients with hepatocellular carcinoma (HCC) in the intermediate stage according to the Barcelona Clinic Liver Cancer (BCLC) guidelines. Recently, balloon-occluded TACE (B-TACE) was developed in Japan. Despite the lack of a clear definition, B-TACE is generally defined as the infusion of emulsion of chemotherapeutic agents with lipiodol followed by gelatin particles under the occlusion of feeding arteries by a microballoon catheter, which leads to the dense lipiodol emulsion (LE) accumulation in HCC nodules. This phenomenon cannot be explained only by the prevention of proximal migration and leakage of embolization materials; it further involves causing local changes in the hemodynamics of the surrounding occlusion artery and targeted HCC nodules. Balloon-occluded arterial stump pressure plays an important role in the dense LE accumulation in targeted HCC nodules. Although randomized controlled trials comparing the therapeutic effect and the prognosis of B-TACE to those of the other TACE procedures, such as conventional-TACE and drug-eluting beads TACE, are still lacking, B-TACE is thought to be a promising treatment. The purpose of this review is to summarize the mechanism, therapeutic effect, indication, prognosis and complications of B-TACE.
Core tip: Balloon-occluded transcatheter arterial chemoembolization (B-TACE) was recently developed in Japan. Despite the lack of a clear definition, B-TACE is generally defined as the infusion of emulsion of chemotherapeutic agents with lipiodol followed by gelatin particles under the occlusion of feeding arteries by a microballoon catheter. Although randomized controlled trials comparing the therapeutic effect and the prognosis of B-TACE to those of the other TACE procedures are still lacking, B-TACE is thought to be a promising treatment. The purpose of this review is to summarize the mechanism, therapeutic effect, indication, prognosis and complications of B-TACE.
Citation: Hatanaka T, Arai H, Kakizaki S. Balloon-occluded transcatheter arterial chemoembolization for hepatocellular carcinoma. World J Hepatol 2018; 10(7): 485-495
Liver cancer ranks sixth as the common malignant neoplasm and second as the cause of death worldwide[1], and hepatocellular carcinoma (HCC) is the most common type of malignant liver tumors[2]. According to the Barcelona Clinic Liver Cancer (BCLC) guidelines, transcatheter arterial chemoembolization (TACE) is an established treatment for patients with HCC in the intermediate stage[3]. The median survival of untreated patients at the intermediate stage, who present with multinodular without vascular invasion or extrahepatic metastasis, performance status 0 and Child-Pugh class A or B, is reported to be 16 mo[4,5], and TACE prolongs their overall survival compared to that of a control group[6,7].
TACE is performed through the injection of single or multiple chemotherapeutic agents after the catheterization of tumor-feeding arteries, followed by the embolization of the same vessels in order to gain a synergistic effect of cytotoxicity and ischemia[3,8]. Conventional-TACE (C-TACE) is defined as the injection of a mixture of anticancer agents with lipiodol followed by embolic materials, such as gelatin particles, calibrated microspheres or polyvinyl alcohol, and drug-eluting beads TACE (DEB-TACE) is defined as the infusion of microspheres onto which chemotherapeutic agents is loaded or adsorbed to achieve a sustained in vivo drug release[8,9].
Recently, balloon-occluded TACE (B-TACE), which was first reported by Irie et al[10], has been developed in Japan. Although it is not mentioned in several guidelines[3,11,12] and its clear definition has not been established, it is generally defined as the infusion of emulsion of chemotherapeutic agents with lipiodol followed by gelatin particles under the occlusion of feeding arteries by a microballoon catheter. The occlusion of the feeding arteries result in the dense lipiodol emulsion (LE) accumulation in targeted nodules[10]. The therapeutic effect of B-TACE was better than that of C-TACE according to several previous reports[13-15], although those were retrospective and small in scale. In addition, randomized controlled trials (RCTs) comparing the therapeutic effect and the prognosis of B-TACE to those of other TACE procedures are still lacking.
Table 1 depicts the key findings of the therapeutic effect and overall survival of B-TACE. With this potential limitation in mind, in the present review, we describe the current understanding of the mechanism, therapeutic effect, indication, overall survival and complications of B-TACE.
Table 1 Summary of retrospective studies of therapeutic effect and overall survival of balloon-occluded transcatheter arterial chemoembolization for hepatocellular carcinoma.
The 1-, 2-, and 3-yr survival rates were 76.8%, 57.3%, and 46.7%, respectively
The number of tumors and α-fetoprotein level were predictive factors for the tumor response and serum albumin and overall response (CR + PR) were predictive factors for prognosis
The presence of portal vein visualization, tumor on the subcapsular portion, and successful subsegmental artery embolization were predictive factors for the tumor response
The local recurrence rates at 6, 12 mo were 11.1 %, 26.2%, respectively. The medan recurrence time was 9 mo
NA
The CT value just after B-TACE was a predictive factor for the tumor response
BALLOON-OCCLUDED TACE PROCEDURE
Microballoon catheters
A 3-Fr microballoon catheter was used in the study reported by Irie et al[10]. However, it is sometimes difficult to advance a microballoon catheter into the targeted tumor-feeding arteries selectively[16]. Moreover, a 5- or 6-Fr guiding catheter was required when we used a 3-Fr microballoon catheter for B-TACE, which is more invasive than C-TACE[16]. Microballoon catheters have improved in recent years, and a 1.8-Fr microballoon catheter (Logos, Piolax, Kanagawa, Japan; or Attendant, Terumo Clinical Supply, Tokyo, Japan) is now available, enabling us to insert the catheter more selectively and more peripherally[16]. We are able to coaxially advanced these microballoon catheters through a typical 4-Fr parent catheter[16]. The proximal side consists of two ports in these microballoon catheters: the microballoon lumen and the microguidewire lumen, the diameter of which is 0.017-0.018 inches[16].
B-TACE procedure
Although a clear definition of B-TACE has not been established and several details concerning the procedure vary markedly among institutions, we will attempt to briefly describe the main points of B-TACE.
The right femoral artery is punctured under local anesthesia. A 4- or 5-Fr parent catheter is then placed in the celiac artery (CeA) or superior mesenteric artery (SMA), and angiography is carried out to assess the anatomy of the hepatic artery, tumor stains, the feeding arteries and arteriovenous shunting. In some institutions, cone-beam computed tomography (CBCT) and angiography-assisted computed tomography (CT) is performed to diagnose the HCC and evaluate the tumor-feeding arteries. A microballoon catheter is inserted into the tumor-feeding arteries over the guidewire as selectively as possible. When the selective insertion of the microballoon catheter into the targeted arteries is difficult, such as in patients with tortuous anatomies of the CeA or SMA, using a microballoon catheter as an anchor might be useful for achieving deep cannulation with the parent catheter[17]. The tumor-feeding artery is then occluded, and the emulsion of lipiodol and anticancer drugs is infused under radiographic guidance. The proportion of lipiodol to anticancer drugs was as follow: 70 mg of Miriplatin[18,19], which is most commonly used in B-TACE, was suspended with 3.5 mL of lipiodol (20 mg/mL); 10 mg of epirubicin[20] with 1-2 mL of lipiodol (5-10 mg/mL); 10 mg of doxorubicin hydrochloride and 2 mg of mitomycin C with 5-10 ml of lipiodol (5-10 mg/mL and 1-2 mg/mL, respectively)[10,15]. Digital angiography is sometimes useful for checking for the flow of LE droplets outside the target areas. LE is infused until sufficient filling of the targeted nodule, overflow into the intrahepatic collateral arteries or the presence of portal vein visualization is observed. The fragmented gelatin sponge slurry is then injected into the blood vessels until the distal vessel is embolized. We describe a typical B-TACE procedure in Figures 1-3.
Figure 1 A 71-year-old female patient with hepatitis-C related hepatocellular carcinoma 45 mm in diameter underwent balloon-occluded transcatheter arterial chemoembolization.
A: A 3-Fr microballoon catheter was inserted into a tumor-feeding artery. After achieving occlusion with the microballoon catheter (yellow arrowhead), emulsion of lipiodol and miriplatin was infused until the cancer nodule (white arrowhead) was sufficiently filled. Fragmented gelatin sponge slurry was then injected; B: Just after B-TACE, computed tomography (CT) showed a dense lipiodol emulsion (LE) accumulation in HCC nodules (red arrowhead); C: Four years after B-TACE, CT showed that the volume of the LE accumulation was reduced (black arrowhead) with no local recurrence. HCC: Hepatocellular carcinoma; B-TACE: Balloon-occluded transcatheter arterial chemoembolization.
Figure 2 A 75-year-old man with hepatitis-B related hepatocellular carcinoma.
A: Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging (EOB-MRI) showed that HCC was slightly enhanced in the arterial phase (white arrowhead); B: While angiography did not show the tumor stain obviously, we injected the lipiodol emulsion (LE) and fragmented gelatin sponge slurry from tumor-feeding artery under occlusion with microballoon inflation; C: A favorable LE accumulation (black arrowhead) was seen on computed tomography one day after balloon-occluded transcatheter arterial chemoembolization. HCC: Hepatocellular carcinoma.
Figure 3 A 74-year-old woman with hepatitis-C related multiple hepatocellular carcinoma.
A: Contrast-enhanced computed tomography (CT) showed that multiple HCC nodules were observed, aggregated at segment 8 (white arrowhead); B: Computed tomography showed that the dense lipiodol emulsion (LE) accumulations (red arrowhead) were observed just after balloon-occluded transcatheter arterial chemoembolization (B-TACE) for multiple HCC; C: We carried out additional B-TACE because local recurrence was detected on follow-up CT. Favorable LE accumulations were observed just after additional B-TACE (yellow arrowhead); D: Three month after additional B-TACE, local recurrence was not observed, and the LE accumulations were shrinking (black arrowhead). HCC: Hepatocellular carcinoma.
MECHANISM OF B-TACE
Irie et al[10] reported that they found dense lipiodol emulsion (LE) accumulation in HCC nodules when they used a 3-Fr microballoon catheter in selective TACE with occlusion of feeding arteries. Denser LE accumulation in targeted HCC nodules means more accumulation of anticancer drugs, leading to more therapeutic effect[21,22]. Therefore, revealing this mechanism is important for hepatologists and interventional radiologists in daily clinical practice.
Relationship between the balloon-occluded arterial stump pressure and the dense LE accumulation
The dense LE accumulation caused by the occlusion of feeding arteries cannot be explained only by the prevention of proximal migration and leakage of embolization materials; it also involves causing local changes in the hemodynamics of the surrounding occlusion artery and targeted tumors. Irie et al[10] reported that the pulsatile movement of LE droplets was observed after the inflation of the tip of a balloon catheter, with the peripheral arterial blood flow unable to be stopped. Because stasis of an LE droplet was observed even at the tip of the microballoon catheter, the authors speculated that the distal arterial blood flow did not come from leakage though the space between the balloon and the occluded artery. The intrahepatic collateral arteries, such as the peribiliary plexus[23], interlobar communicating arcade[24] and isolated artery[25], were considered to help maintain the distal arterial blood flow, based on the observation of anastomotic vessels with collateral arteries on digital subtraction angiography (DSA) under occlusion[10]. Consequently, the BOASP is reduced compared to the mean arterial pressure without balloon occlusion and more decreased BOASP allows the injection of LE under higher pressure. He also demonstrated that BOASP is responsible for the dense LE accumulation and the BOASP ≥ 64 mmHg is predictive for the presence of thick collateral arteries and less dense LE accumulation[10].
Matsumoto et al[26] reported that they used a 1.8-Fr microballoon catheter and measured the BOASP at each lobar, segmental and subsegmental arteries before B-TACE treatment. He showed that the BOASP ≥ 64 mmHg was founded at A1, A4, A8, anterior segment artery, right hepatic artery (RHA) and left hepatic artery (LHA) whereas the BOASP ≥ 64 mmHg was never seen at the other segmental and subsegmental arteries and the BOASP was independent of the size and number of tumors[26]. He presumed that this result was affected by the presence of intrahepatic collateral arteries, especially the communicating arcade in the hilum which is a relatively thick anastomosis between the right and left hepatic arteries and originates mainly from A4 and from anterior segment artery or the right hepatic artery[24,26]. BOASP ≥ 64 mmHg at A1 artery could be explained by the studies reported by Miyayama et al[27,28] in which the right branch of the communicating artery in the hilum might have been A1[26]. So, B-TACE treatment in A1, A4, A8, anterior segment artery, RHA and LHA possibly caused less dense LE accumulation in targeted HCC nodules[26]. However, this study is small sample size in measured hepatic arteries and lack of the statistical analysis. A large number of validation studies are needed.
Kakuta et al[29] examined the changes in the stump pressure with and without balloon occlusion as well as after B-TACE treatment. The mean blood pressure at the targeted occluded artery was 97 mmHg before balloon occlusion and decreased to 49.1 mmHg immediately after balloon occlusion, with a statistically significance[29]. Five minutes after balloon occlusion, the mean blood pressure was 50.4 mmHg, and the maintenance of a decreased blood pressure was observed[29]. After the injection of LE and gelatin sponge particles, the mean blood pressure increased to 70.6 mmHg, which was significantly higher than that immediately after balloon occlusion (P < 0.001)[29]. The mean arterial blood pressure without balloon occlusion after B-TACE was not significantly different from that without balloon occlusion before B-TACE (P = 0.9107)[29]. Although no significant differences were observed among the stump pressures at the first-, second- and third-order branches, the proportion of stump pressure < 64 mmHg at third-order branches tended to be higher than that at first- or second-order branches[29]. Advancing a microballoon catheter to a more peripheral artery appeared to cause the stump pressure to decrease more[29]. A further investigation is needed to determine whether or not the occlusion of a more distal artery results in a more decreased BOASP.
Although these previous studies[10,26,29] have provided only preliminary and limited data, the findings indicate that the BOASP plays an important role in the dense LE accumulation in targeted HCC nodules. Further studies regarding whether or not the BOSAP can predict the long-term therapeutic effect should be conducted.
Hemodynamic changes assessed by CBCT and angio-assisted CT
Three reports[30-32] have explored the hemodynamic changes assessed by balloon occlusion using CBCT and angiography-assisted CT. Ishikawa et al[30] reported that the CBCT pixel values of tumor enhancement increased after balloon occlusion in 37 of the 52 nodules, whereas it decreased in the remaining 15 nodules. Yoshimatsu et al[31] showed that the degree of tumor enhancement on selective CT during hepatic angiography (CTHA) increased after balloon occlusion in 3 of the 27 nodules, while it decreased in 11 nodules. Asayama et al[32] also reported that 15 of the 35 nodules showed decreased enhancement or perfusion defects on CTHA with balloon occlusion. While the percentage of decreased tumor enhancement varied markedly among those studies, it remained a negative predictive factor for a dense LE accumulation[30,31] and short-term therapeutic effect[32]. It can be presumed that the blood flow from the occluded artery reduced and the blood flow from the collateral arteries relatively increased[31,32]. In relation to this, a discrepancy was noted between the tumor enhancement on selective CTHA with balloon occlusion and a dense LE accumulation after B-TACE, which was higher than the tumor enhancement grade[31]. Although CBCT[33-35] and CTHA[36,37] are well known to be useful tools for identifying the tumor-feeding arteries, evaluating the embolized area and avoiding nontargeted embolization, the same findings were reported in selective C-TACE[38]. A validation study will be needed to confirm whether or not a decreased tumor enhancement after balloon occlusion can predict the short- and long-term therapeutic effects.
With regard to the analysis of CT findings during arterial portography (CTAP), the reduction in size of the tumorous portal perfusion defects on CTAP with balloon occlusion was observed in 90% (18/20) of nodules. Its mean size significantly decreased from 21.9 to 19.1 mm in diameter (P = 0.0001). No decrease in the tumorous portal perfusion defect area significantly influenced the poor dense LE accumulation in the tumor[31]. The authors speculated that the decrease in the BOASP enabled the pressure gradient from the hepatic artery to the portal vein to also decrease, thus resulting in a relative increase in the blood flow from the portal vein in the surrounding tumor[31]. In other words, no change in the size of the tumorous portal perfusion defect may indicate no decrease in the BOASP[31]. To facilitate our understanding of the mechanism of B-TACE, we summarize the main findings mentioned above and present them in a schematic illustration in Figure 4.
Figure 4 A schematic illustration of the balloon-occluded transcatheter arterial chemoembolization procedure.
A: A microballoon catheter is inserted into the tumor-feeding artery and inflated to occlude it. If the distal arterial blood flow cannot be stopped, the intrahepatic collateral arteries (ICAs) may be maintaining the distal arterial blood flow; B: When the ICAs are thin, the balloon-occluded arterial stump pressure (BOASP) is remarkably reduced compared to the arterial pressure without balloon occlusion. In this situation, we might observe increased tumor enhancement on selective computed tomography during hepatic angiography (CTHA) after balloon occlusion. A remarkable reduction in the BOASP is thought to allow us to inject the lipiodol emulsion (LE) under higher pressure, leading to the denser LE accumulation in targeted tumors. The BOASP after the injection of LE and gelatin particles is significantly higher than that before treatment; C and D: When the ICAs are thick, the BOASP is expected to be mildly reduced or unchanged because of the adequate blood flow from a thick ICA. In this situation, we might observe decreased tumor enhancement on CTHA after balloon occlusion. We would probably inject the LE under lower pressure in such a situation, thereby achieving a less-dense LE accumulation.
THERAPEUTIC EFFECT OF B-TACE
Short-term therapeutic effect and local recurrence rate
In many previous studies, the short-term therapeutic effect of B-TACE was evaluated mainly by the Response Evaluation Criteria in Cancer of the Liver (RECICL) proposed by the Liver Cancer Study Group of Japan[39]. The treatment effect (TE) was determined by the radiological findings 1-3 mo after B-TACE treatment and defined as follows: TE4, tumor necrosis of 100% or 100% reduction; TE3, tumor necrosis of 50%-100% or 50%-100% reduction in tumor size; TE1, tumor enlargement of > 50% regardless of necrosis; TE2, effect other than TE3 or TE1[39]. According to previous reports[13,15,32,40,41], the rate of TE4 of targeted HCC nodules treated with B-TACE was 8.6%-89.3%, and that of TE3 was 8.5%-48.6%, with a response rate of 56.3%-100%.
Kawamura et al[40] showed that the presence of portal vein visualization during treatment was associated with an objective response, which is consistent with findings of the study reported by Miyayama et al[42]. However, the evaluation of the therapeutic effect of B-TACE in these studies[13,15,32,40,41] was limited to only targeted lesions and did not include the appearance of new lesions. According to a study[43] evaluated based on the overall response, including target lesions, non-target lesions and the appearance of new lesion, 35 patients (53.0%) experienced complete response (CR), 7 patients (10.6%) partial response (PR), 13 patients (19.7%) stable disease, and 11 patients (16.7%) progressive disease. The rate of a response rate and a disease control rate were 63.6% and 83.3%, respectively. Furthermore, a multivariate analysis showed that a solitary tumor and serum α-fetoprotein level were significantly relevant to the tumor response[43].
Regarding the analysis of the local recurrence rate, Ishikawa et al[44] showed that the median recurrence time and the local recurrence rate at 6 mo and 12 mo were 9 mo and 11.1% and 26.2%. The authors further revealed that only the CT value just after B-TACE was significantly relevant to local recurrence in a multivariate analysis[44]. CBCT was also deemed useful as a substitute for conventional CT to evaluate the degree of dense LE accumulation quantitatively in targeted HCC nodules[45]. Irie et al[15] also showed that the control rates of primary nodule treated by B-TACE at 1, 3 and 5 years were 92.4%, 69.9% and 69.9%, respectively. However, these were retrospective studies, and the number of nodules per patient was small (many patients had solitary nodules). The results should therefore be interpreted with caution when extrapolating to HCC patients with more nodules. A summary of the previous studies is shown in Table 1. A prospective validation study is warranted.
Suitable anticancer agents
The anticancer agents that have been used in B-TACE are as follows: Miriplatin[13,14,31,32,40,41,44], which was the most commonly used; cisplatin[29,31]; epirubicin[20] and a mixture of doxorubicin hydrochloride and mitomycin[10,15]. Miriplatin, which is a lipophilic platinum complex[18,19], has been used in C-TACE[46]. A retrospective study[47] showed that the local recurrence rate was significantly higher after superselective TACE with miriplatin than with epirubucin and mitomycin. This may be attributed to its high viscosity, and warmed miriplatin may reduce its viscosity, possibly overcoming its disadvantages and increasing its therapeutic effect[48,49]. Therefore, B-TACE with warmed miriplatin may exert a better therapeutic effect than that with miriplatin at room temperature. In this connection, arterial vascular damage is less severe in patients treated with miriplatin than in those treated with epirubicin[50]. Although no RCT has compared antitumor agents, miriplatin might be suitable as an anticancer agent in B-TACE. Further studies should be conducted.
Comparing the effectiveness of B-TACE and C-TACE
Reliable data on the comparative efficacy between B-TACE and C-TACE are still lacking, with only four retrospective studies reported. Arai et al[13] reported that the targeted therapeutic effect of B-TACE with miriplatin was better than that of C-TACE, and the mean total dose of miriplatin in B-TACE was higher than that of C-TACE. They presumed that inflating the microballoon catheter decreased the arterial pressure proximal of the tip of the catheter and blocked the backflow of miriplatin, resulting in a higher total dose of miriplatin and a better therapeutic effect on targeted nodules than with C-TACE. Ogawa et al[14] also reported that TE4 was observed in 29 patients (49.2%) treated with B-TACE and in 10 patients (27%) treated with C-TACE, indicating that local efficacy of B-TACE was significantly better than that of C-TACE. Irie et al[15] reported that the short-term treatment effect based on RECICL criteria was significantly better in B-TACE group than that in the C-TACE group, and the tumor control rates of the targeted nodule were significantly improved in the B-TACE group compared to C-TACE group. However, Maruyama et al[20] reported that the local control rate in B-TACE group were not significantly better than in the C-TACE group. The major cause of this was the lack of a significant difference between the two groups in the analysis of the LE ratio. The LE ratio, which was calculated as the ratio of the LE concentration in the targeted tumor to that in the surrounding embolized non-cancerous area, was considered to be an indicator of the selectivity of the LE accumulation in HCC[10]. Alternatively, this finding may have been observed because most patients received B-TACE treatment at the lobar or segmental level, resulting in a less-marked decrease in the BOASP and therefore a less-marked therapeutic effect[26]. More large-scale prospective studies are warranted.
INDICATIONS OF B-TACE
Since no definitive indications of B-TACE have been established to date, we explored potential factors and conditions supporting the performance of B-TACE. Summarizing the findings of the previous studies mentioned above, the following factors and conditions are known to be related to a dense LE accumulation in targeted HCC nodules and the therapeutic effect of B-TACE: a BOASP ≥ 64 mmHg[10]; microballoon occlusion at A1, A4, A8, anterior segment artery, RHA or LHA[26]; decreased tumor enhancement on CBCT and CTHA[30-32]; no decrease in the tumorous portal perfusion defect on CTAP[31]; tumor location on the subcapsular portion[40]; successful subsegmental feeding artery embolization[40]; the presence of portal vein visualization[40]; a high CT value just after B-TACE[44]; solitary tumor[43] and a low serum α-fetoprotein level[43]. Based on studies[13-15] showing that patients with fewer tumor nodules experienced a better therapeutic effect with B-TACE than with C-TACE, B-TACE might be a better indication than C-TACE in patients with fewer tumor nodules. Prospective validation studies are needed to clarify the indications of B-TACE.
The contraindications of B-TACE were thought to be almost the same as those for C-TACE treatment: Child-Pugh class C, no tumor thrombosis in the first branch or main portal vein, extrahepatic metastasis, refractory ascites, hepatic encephalopathy, presence of high-flow arterioportal or arteriovenous shunts, and allergy to contrast medium.
OVERALL SURVIVAL OF B-TACE
Hatanaka et al[43] reported that the survival rates at 1, 3 and 5 years in patients after B-TACE were 76.8%, 57.3% and 46.7%, respectively, and the median survival time was 902 d. They also revealed that a serum albumin level ≥ 3.4 g/dL and an overall response of CR+PR were favorable prognostic factors in a multivariate analysis[43]. Serum albumin is one of the most well-known prognostic factors for patients with HCC and has been adopted and integrated into several staging systems, including the BCLC staging system[3], Cancer of the Liver Italian Program (CLIP) score[51] and Japan Integrated Staging score (JIS score)[52]. According to previous studies of TACE[53,54], the overall response has been reported to be an independent factor affecting for the survival of HCC patients. Although the findings reported by Hatanaka et al[43] were consistent with those of previous studies[53,54], the results were based on a single-arm and single-institution study. Additional validation studies are therefore warranted.
One problem that remains to be solved is whether or not B-TACE improves the overall survival compared to other TACE treatments. Unfortunately, no RCTs have compared B-TACE with other TACE treatments, such as C-TACE and DEB-TACE, and only one historical control study[15] with patients who had solitary or two nodules has been reported. However, while it was small in scale, that study found that B-TACE was a significant factor predicting for the overall survival in a multivariate analysis[15]. A large-scale prospective study is therefore warranted.
COMPLICATIONS OF B-TACE
According to previous reports[13,20,43,44] evaluated by the Common Terminology Criteria for Adverse Effects (CT–CAE), all grades of fever were reported as complications in 44.2%-68% of cases, nausea in 16.3%-28%, abdominal pain in 14%-36.7%, ascites in 12.2%-15.2%, elevated total bilirubin in 34%-62.2%, elevated alanine aminotransferase (ALT) in 78.8%-96%, elevated serum creatine in 8.1%-9.1%, leukocytopenia in 53.1%-59%, thrombocytopenia in 71.3%-87.7%, anorexia in 31.3% and vagovagal reflex in 12%, while a grade 3/4 fever was reported as a complication in 0%-6% of cases, elevated total bilirubin in 0%-6.1%, elevated ALT in 9.1%-18%, leukocytopenia in 0%-12.1% and thrombocytopenia in 7.6%-12.2%. In an analysis comparing the adverse events of B-TACE with those of C-TACE, the rate of increased levels of ALT was significantly higher in the B-TACE group, with no significant differences in the clinical symptoms or other laboratory data between the two groups[13,20].
Hatanaka et al[43] reported no mortalities, but the development of biloma requiring percutaneous transhepatic biliary drainage after B-TACE was observed in 1 patient (1.5%) who had intrahepatic dilation on preoperative CT. Maruyama et al[20] reported that liver abscess was observed in 3 patients (6%), and liver infarction was observed in 1 patient (2%), with bile duct dilation indicated as a significant predictive factor in a multivariate analysis. Careful consideration must be given to perform the B-TACE for the patients with bile duct dilation[43]. Large-scale validation studies are therefore needed to confirm these findings.
CONCLUSION
B-TACE represents a feasible and promising therapy for the treatment of HCC patients, especially those with few nodules. Although no definitive indication of B-TACE in the common clinical practice has yet been established, leaving the decision to perform this procedure up to gastroenterologist or radiologist based on their expertise with or the availability of microballoon catheters, B-TACE may represent an established treatment in HCC patients.
Footnotes
Manuscript source: Invited manuscript
Specialty type: Gastroenterology and hepatology
Country of origin: Japan
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